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Major New Review Supports the Broader Potential of CeNeS COMT,Inhibitor Discovery Programme

Parkinson's disease. Academic data continues to suggest that COMT inhibitors may also have therapeutic utility in addressing the poorly treated negative symptoms of schizophrenia. This is in addition to the established market for COMT inhibitors in the treatment of Parkinson's disease. If this extra indication is established the market size for a novel, centrally acting COMT inhibitor would increase substantially". ENDS

1 Apud and Weinberger, CNS Drugs 2007, 21, 535-557.

For more information please contact: CeNeS Pharmaceuticals plc Neil Clark, CEO Tel: +44 (0)1223 266 466

JM Finn Geoff Nash Tel: +44(0) 207 628 9688

Financial Dynamics Ben Brewerton/Emma Thompson Tel: + 44 (0) 207 831 3113 About CeNeS Pharmaceuticals CeNeS is a biopharmaceutical company specialising in the development and commercialisation of drugs for pain control, sedation and other CNS disorders such as Parkinson's disease. The company is based in Cambridge, England. For further information visit the CeNeS web site: www.cenes.com

About COMT inhibitors Two COMT inhibitors have been introduced to the market, tolcapone and entacapone. However, tolcapone was withdrawn from the EU market in late 1998 due to liver toxicity, which is unrelated to COMT inhibition. Tolcapone has recently been re-introduced to the market in Europe but, as in the US, its use is severely restricted. As such, entacapone (co-marketed by Orion and Novartis) is the only unrestricted COMT inhibitor available in the major markets. However, entacapone has a number of drawbacks, namely a short half-life, relatively low oral bioavailability and minimal brain penetration. Tolcapone and entacapone, in common with the majority of known potent COMT inhibitors, contain the undesirable 3-nitrocatechol unit that is associated with poor oral absorption, short plasma half-life and extensive metabolism issues. The goal of breaking away from this nitrocatecho
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