Navigation Links
Major Gene Study Uncovers Secrets of Leukemia

St. Jude Study Scans 350,000 Locations Across the Genome From 242 Patients and Identifies New Mutations That Contribute to Acute Lymphoblastic Leukemia, Suggesting New Targets for Improved Therapy

MEMPHIS, Tenn., March 07, 2007 /PRNewswire/ -- Investigators at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children. The discovery not only suggests novel methods for treating pediatric ALL, but also provides a roadmap for the identification of unsuspected mutations in adult cancers.

The St. Jude team used microarrays, postage-stamp-sized chips that contain DNA fragments, which allowed researchers to investigate more than 350,000 markers called single nucleotide polymorphisms. Single nucleotide polymorphisms are individual variations in the DNA that are spaced across the human chromosomes. Single nucleotide polymorphisms function as flags for researchers, allowing them to detect specific deletions of DNA in a gene or increases in the number of specific genes at a level of detail that was previously unattainable. The St. Jude group used this approach to analyze leukemia samples from 242 pediatric patients with ALL. This identified an unexpectedly high frequency of mutations involving genes that function as master regulators of normal B-cell development and differentiation.

A report on this work appears in the March 7 online edition of "Nature."

"The results of our study demonstrate that it is possible to significantly speed the identification of the genetic lesions that are the underlying cause of not only ALL, but also many other cancers, including those affecting adults," said James Downing, M.D., scientific director and chair of the Pathology department at St. Jude. He is senior author of the paper.

The study found that 40 percent of patie
'"/>




Page: 1 2 3

Related medicine technology :

1. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
2. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
3. New Study Results Provide Additional Data about Short- and Long-Term Use of Desvenlafaxine Succinate in the Treatment of Adults with Major Depressive Disorder
4. Pooled Studies Showed Desvenlafaxine Succinate Significantly Improved Painful Symptoms and Anxious Symptoms Associated with Major Depressive Disorder in Adults, Compared With Placebo
5. Six-Week Investigational Study In Adults With Major Depressive Disorder Evaluates The Effectiveness of Adjunctive Aripiprazole Therapy With Antidepressants
6. Major Manufacturer of Unapproved and Adulterated Drugs
7. Exforge Helps Vast Majority of Patients Effectively Control Their Blood Pressure After Failing on Other Medicines, According to New Clinical Data
8. CuraGen and TopoTarget Announce New Clinical Results With Belinostat to be Reported at Upcoming Major Medical Meetings
9. Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference
10. Schering-Plough Addresses Major Milestones and Challenges in Treatment of Patients With Chronic Hepatitis C
11. New Clinical Data for Cytogens Quadramet and Prostacint to be Reported at Upcoming Major Medical Meetings
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Major Gene Study Uncovers Secrets Leukemia
(Date:9/19/2014)... HILL, N.C. , Sept. 19, 2014 /PRNewswire/ ... role in forging relationships with key opinion leaders ... market and competition. Despite the critical nature of ... created many challenges, including altering the landscape for ... According to research, the oversight responsibility ...
(Date:9/19/2014)... , Sept. 19, 2014 A pharmaceutical executive ... LLC with three issues he wanted the research and ... of external personnel (especially for secondary research) to maximize ... face of increased workload , Automation of market ... management , How to implement and manage those ...
(Date:9/19/2014)... Sept. 19, 2014 "Copay coupons," ... sales of brand drugs among patients with prescription drug ... to a new report  from the Department ... Inspector General (OIG). Federal anti-kickback laws prohibit suppliers ... are subsidized by the federal government. ...
Breaking Medicine Technology:Role of Medical Science Liaisons Shifting in Healthcare Industry 2In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2PCMA: New OIG Report Cites Drug Manufacturer "Copay Coupon" Use in Medicare Part D 2
... NxStage Medical, Inc. (Nasdaq: NXTM ), a leading ... its financial results for the third quarter ended September 30, ... of the financial markets. , NxStage will also host a ... 5, 2009 to discuss its third quarter financial results. To ...
... Conn., Oct. 15 AmeriCares has awarded its annual ... the largest health care products and services companies in ... the award today at the Healthcare Distribution Management Association,s ... Power of Partnership Award was created by AmeriCares and ...
Cached Medicine Technology:NxStage(R) to Report Third Quarter 2009 Financial Results 2AmeriCares Honors Cardinal Health with Power of Partnership Award 2AmeriCares Honors Cardinal Health with Power of Partnership Award 3
(Date:9/21/2014)... (PRWEB) September 21, 2014 Hundreds ... move forward in Pennsylvania’s Philadelphia Court of Common ... documents, the proceeding’s next monthly meeting has been ... number 100300296) , “Our Firm is representing a ... in this litigation. We are pleased with its ...
(Date:9/21/2014)... Dallas, Texas (PRWEB) September 21, 2014 ... Administration (FDA) in 1996, GSK’s Flovent (fluticasone propionate) ... activity. It is used for the maintenance treatment ... is now available in two formulations, Diskus and ... and 2004, respectively. Flovent’s active ingredient, fluticasone propionate, ...
(Date:9/21/2014)... An experienced review website in the global market, Top10BestSEOHosting.com, ... announced that FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ), GoDaddy and Bluehost ... has been a boom in websites in recent years, ... in the number of web hosting companies that offer ... VPS (Virtual Private Server) is the method of partitioning ...
(Date:9/21/2014)... 2014 C8 lawsuits move forward in ... the list of 20 possible C8 lawsuits selected ... six, reports Wright & Schulte LLC. Court records show ... 2500 C8 lawsuits filed that represent individuals who purportedly ... a result of being exposed to water contaminated by ...
(Date:9/20/2014)... Diabetes Protocol , a breakthrough new ... thousands of people learn how to naturally manage and ... prescriptions has caught the attention of Shane Michaels, prompting ... of millions of people in the U.S. today who ... and unfortunately, big pharma makes a killing just by ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 4Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Top10BestSEOHosting.com: FatCow, GoDaddy And Bluehost Are The Best VPS Hosting Suppliers 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2
... Recovery for Many Facing Health CrisesCHICAGO, Jan. 15 Does ... challenges have found support and compassion through online communities such ... love is more than a dozen roses or candlelit dinner ... and defying the odds for survival. Just ask Lisa, ...
... information on its revamped website. AccessRx has provided tens of ... 1998. , ... (PRWEB) January 15, ... consumer information on its revamped website. AccessRx has provided tens ...
... Two radon-induced lung cancer survivors will be joined by ... Council Radon Awards Ceremony at the National Press ... the U.S. EPA, the ceremony is part of National ... and winners of the National Radon Poster Contest; but ...
... & Nephew,s Advanced Wound Management division (LSE: SN; NYSE: ... Court in the High Court of Justice of England and ... a temporary injunction prohibiting Smith & Nephew from commercializing foam ... Kingdom. The temporary injunction will remain in place until the ...
... Nationally; Many People May Not Realize They,re InfectedHARRISBURG, Pa., ... in the number of reported cases of gonorrhea and ... testing by men and women, according to the Department ... common bacterial sexually transmitted diseases is below the national ...
... with CorVel Corporation,s (Nasdaq: CRVL ) quarterly earnings release, CorVel will be ... 3rd at 11:30 am Eastern Time. , , Event: ... Dan Starck, President and CEO, ... Date: 11:30 am Eastern Time, Tuesday, ...
Cached Medicine News:Health News:More than Just a Box of Chocolates 2Health News:More than Just a Box of Chocolates 3Health News:AccessRx.com Launches Redesigned Website, Adds Content and Builds Online Community 2Health News:Radiation Victims to Rally In Washington - Demand Congressional Action to Protect Homebuyers; Organization Labels EPA's Radon Program a 'Deadly Failure' 2Health News:Radiation Victims to Rally In Washington - Demand Congressional Action to Protect Homebuyers; Organization Labels EPA's Radon Program a 'Deadly Failure' 3Health News:Smith & Nephew Advanced Wound Management Comments on Temporary Injunction in United Kingdom 2Health News:Smith & Nephew Advanced Wound Management Comments on Temporary Injunction in United Kingdom 3Health News:CorVel Corporation Announces Earnings Release Webcast 2
... Eliminate the need for makeshift, modified nebulizer ... waste time gathering parts when your patient ... to deliver the utmost in Heliox rescue ... is fast becoming the standard of care ...
... Graham-Field has been developing diverse ... 58 years. Our medical-surgical products ... for innovation, quality and customer ... include the Labtron® line of ...
... Entrainment Nebulizers deliver particulate humidity in the ... chronic secretion patients. For your convenience, Thera-Mist® ... supply of sterile water., ,The P30000N, ... of 20-50% with a total flow range ...
... For use with metered dose inhalers., ... aerosolized medication from MDI canisters. Its versatile ... a ventilator circuit, in conjunction with an ... routine, oral inhalation. ACE may also be ...
Medicine Products: