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Lyrica Significantly Reduced Pain and Helped Patients Manage the,Symptoms of Fibromyalgia, Data Show

ated with Lyrica reduced their pain by 50 percent or more compared with placebo. Of those patients taking 600mg of Lyrica a day, 30 percent said their pain was cut in half or better; 27 percent of those taking 450mg a day and 24 percent of those taking 300mg also reported this level of pain relief. Of those taking placebo, 15 percent reported pain reduction of 50 percent or greater.

Patients receiving Lyrica also reported significant improvements in overall health status and outcomes, including measures such as physical function and ability to perform everyday tasks.

The most common side effects in the study were dizziness and somnolence, followed by weight gain, headache and peripheral edema.

The results of these data were submitted to the FDA as part of a supplemental New Drug Application for Lyrica for the treatment of fibromyalgia. Pfizer also intends to pursue a fibromyalgia indication in other major markets worldwide.

About Lyrica

To date, more than five million patients worldwide have used Lyrica.

In the United States, Lyrica (pregabalin) capsules CV is approved for the management of neuropathic pain associated with diabetic peripheral neuropathy and post-herpetic neuralgia, and in epilepsy for the adjunctive treatment of partial onset seizures in adults.

Outside of the United States, Lyrica is approved for use in adults for the treatment of various peripheral and central neuropathic pain indications, including diabetic pain and post-herpetic neuralgia, pain resulting from spinal cord injury, and adjunctive therapy for partial seizures in more than 60 countries. In 2006, Lyrica was also approved in Europe for the treatment of generalized anxiety disorder.

DISCLOSURE NOTICE: The information contained in this release is as of May 1, 2007. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.

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