( or LX211 at 2.5 mg/kg 10 mg/kg or 40 m...)Lux Biosciences' Investigational Therapy for Uveitis, LX211, is,Subject of Two Presentations at Key Ophthalmology Meeting, ARVO,2007,Health

or LX211 at 2.5 mg/kg, 10 mg/kg or 40 mg/kg, with the preventative group beginning injections at day 0 and the therapeutic group beginning injections at day 7 after EAU induction. Six days after EAU induction, researchers began to evaluate the animals daily for clinical scores.

The vehicle-control and LX211 2.5 mg/kg therapeutic groups displayed the earliest clinical manifestations of EAU and highest clinical scores. None of the CsA or LX211 treated rats in the preventative group developed severe clinical disease. Histopathology confirmed that animals treated with LX211 at 40mg/kg were free of disease, in both therapeutic and preventative groups. These results were similar to results seen in the CsA group. LX211 therapeutic groups, 2.5 and 10 mg/kg, showed decreased histopathological EAU scores compared to controls. In rats treated with either LX211 or CsA, antigen-specific and non-specific responses of lymphocytes to the protein used to induce EAU were diminished compared to those of the control group.

"These positive preclinical results, combined with encouraging safety data from human clinical trials in other indications conducted by our partner Isotechnika, provide a strong rationale for our ongoing registration-directed LUMINATE studies of LX211 in uveitis," said Ulrich Grau, Ph.D., Lux Biosciences' president and chief executive officer. "We hope to complete enrollment in the LUMINATE trial program by early 2008 and, if successful, seek regulatory approval for LX211 in late 2008."

About LX211

LX211 is a next-generation calcineurin inhibitor to which Lux Biosciences has an exclusive worldwide license for ophthalmic indications from Isotechnika, Inc., of Edmonton, Canada (Isotechnika's code ISA247). Isotechnika is currently investigating ISA247 in phase 3 clinical trials in psoriasis patients, and in a phase 2b clinical trial in solid organ transplant recipients. The clinical data gathered to date indicate that LX211 is a potent calcin
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