Navigation Links
Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III,Melanoma Demonstrated Significant and Sustained Impact on,Relapse-Free Survival

r /> In the study, participants reached a median 88 percent and 83 percent relative dose intensity, or percent of planned dose intensity, during the induction and maintenance phases, respectively. Forty percent (251 subjects) ceased pegylated interferon alfa-2b therapy due to toxicity or patient’s withdrawal of consent, while approximately 23 percent of subjects continued into year 4 and 5 of treatment. Grade 3 or 4 toxicities, mostly grade 3 in severity, were reported in 45 percent of subjects in the pegylated interferon alfa-2b arm versus
12 percent in the observational arm. These events included primarily Grade 3 fatigue, hepatotoxicity and depression. An ECOG 0-1 Performance Status was maintained in 83 percent of patients during the maintenance phase. These data represent the planned final analysis with a median follow-up of 3.8 years; study participants will be followed for survival for a total of 10 years.

About the Study
This study was designed to assess the efficacy and safety of long-term pegylated interferon alfa-2b vs. observation. Researchers enrolled 1,256 subjects with stage III melanoma. Participants were given pegylated interferon alfa-2b at a dose of 6 ?g/kg/week for an eight week induction phase followed by 3 ?g/kg/wk (maintenance phase), for total treatment duration of 5 years.
“We are pleased with the results of this important study,” said Robert J. Spiegel, M.D., chief medical officer and senior vice president, Schering-Plough Research Institute. “Patient follow-up will continue to assess long-term treatment with pegylated interferon alfa-2b and overall survival.”

About Peg Interferon
Pegylated interferon alfa-2b is not approved in the United States for treatment of melanoma. In the United States, pegylated interferon alfa-2b is indicated for use alone or with ribavirin for the treatment of chronic hepatitis C in patients with compensated liver disease who have not b
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Anesiva Announces Phase 2 Data Showing Substantial, Long-Term Pain Reductions with Adlea(TM) (formerly 4975) in Osteoarthritis of the Knee
2. Surfaxin (Lucinactant) Long-Term Survival Advantage vs. Comparators Published in Pediatrics
3. Long-Term Extension of Ulcerative Colitis Study Shows Remicade Responders Maintained Improvement Through Two Years of Follow-Up
4. New Long-Term Data Analyses for Bifeprunox Show Favorable Effects Versus Placebo in Stabilized Patients with Schizophrenia
5. Medtronic Updates Long-Term ENDEAVOR I-II Clinical Data Showing Sustained Safety and Significant Reductions in Repeat Procedures
6. Taxus VI Clinical Trial Demonstrates Positive Long-Term Outcomes for Moderate-Release Paclitaxel-Eluting Stent at Four Years
7. UCB Presents Long-Term CImzia Data in Crohns Disease
8. PDL BioPharma Announces Long-Term Nuvion Data Presented at 2007 Digestive Disease Week
9. New Study Results Provide Additional Data about Short- and Long-Term Use of Desvenlafaxine Succinate in the Treatment of Adults with Major Depressive Disorder
10. Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension
11. CEL-SCI Presents Long-Term Cancer Survival Data With Multikine
Post Your Comments:
(Date:11/26/2014)... , November 26, 2014 Investor-Edge ... VVUS ), Horizon Pharma PLC (NASDAQ: ... and Johnson (NYSE: JNJ ), and Theravance Inc. ... companies can be accessed at: http://investor-edge.com/register . ... 4,758.25, up 0.07%, the Dow Jones Industrial Average edged 0.02% ...
(Date:11/26/2014)... 26, 2014 A hernia is condition ... protrudes through the wall of a weak muscle area. Obesity, ... are some of the causes of hernias. There are several ... incisional. An inguinal hernia is when part of the abdominal ... found in the area of the umbilicus. A hiatal hernia ...
(Date:11/26/2014)... 2014  Aridis Pharmaceuticals, Inc., a biopharmaceutical company ... infectious diseases, announced today the addition of ... opinion leader in the areas of pneumonia and ... Founder and Chief Executive Officer, Vu ... extensive experience investigating bacterial toxins and key mechanisms ...
Breaking Medicine Technology:Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3
... NovaRx Corporation announced today the appointment of Norrie ... Chief Operating Officer. Dr. Russell brings to the ... and a long history of success driving innovation in ... leading entrepreneurial biotechnology companies developing pioneering new technologies. ...
... 3 Sangamo BioSciences, Inc.,(Nasdaq: SGMO ) ... milestones,achieved in 2008 and preview objectives for 2009 during ... New York City today. , David Smoller, ... discuss the progress and expected potential of the,two companies, ...
Cached Medicine Technology:NovaRx Appoints Industry Veteran as President and COO 2NovaRx Appoints Industry Veteran as President and COO 3Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives 2Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives 3Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives 4Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives 5Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives 6
(Date:11/27/2014)... Los Angeles, CA (PRWEB) November 27, 2014 ... are thrilled to be part of Omadox, a feature ... Film Festival, including an award for best ensemble cast. It ... Festival. This is a great start to a successful cinematic ... experimental/sci-fi, black and white movies. If you enjoy experimental mystery, ...
(Date:11/27/2014)... Acapulco, Guerrero (PRWEB) November 27, 2014 ... the time individuals allot to sleep has lessened, ... televisions and laptops, the quality of sleep has ... workers falls asleep on the job (Reference: ... American worker’s productivity index by an incalculable amount, ...
(Date:11/27/2014)... An inventor from Buffalo, N.Y., knows that ... and she wants to lessen its impact. "After showering ... that there needed to be a way to maintain ... use and producible in design variations, the End Scentuous ... throughout the day. It avoids bad odors, as well ...
(Date:11/27/2014)... York, New York (PRWEB) November 27, 2014 ... ) have been filed in a consolidated ... Liebhard LLP reports. , Documents recently updated ... 1,079 records included in the state proceeding, all ... schizophrenia, bipolar disorder and other psychiatric conditions. Many ...
(Date:11/27/2014)... -- Most babies and young children don,t need medicines ... Drug Administration says. Over-the-counter (OTC) cold and cough ... 2 because they could cause serious and potentially deadly ... about three colds a year, but children get them ... want to give them pain relievers, decongestants and other ...
Breaking Medicine News(10 mins):Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 2Health News:Luciana Lagana and Gregory Graham Join the Award-Winning Cast of the Black-and-White Experimental Mystery Feature Film Omadox. 3Health News:Research Shows Surprising Number of US Workers Affected by Lack of Sleep 2Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 2Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 3Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 4Health News:Steer Clear of Cold Meds for Babies, FDA Advises 2
... Will Feature Nearly 100 Exhibits, Forums on Health Care ... Health Screenings and Top Musicians***LOS LOBOS TO HEADLINE ENTERTAINMENT***SAN ... largest advocacy organization for people age 50+, today announced ... event to San Antonio on May 15-16. ...
... But it,s unlikely these factors cause the neurological condition, experts ... older mothers and children who have breech deliveries are almost ... researchers report. , The findings confirm those of other studies ... genetic base, researchers say. , "A child with breech ...
... surgeons can agree! There is often disagreement between ... the proper therapy for coronary artery disease (CAD)and ... edition of Deutsches rzteblatt International , an ... cardiac surgeons provides answers to the question of ...
... to attend TCT 2009 (Transcatheter Cardiovascular Therapeutics), the ... TCT gathers leading medical researchers and clinicians from ... latest developments in the field of interventional cardiology ... TCT brings state-of-the-art techniques and training to interventional ...
... National Infant Immunization Week is April 25 - May ... To kick off National Infant Immunization Week, ... for all parents to fully immunize their children against ... preventable diseases such as whooping cough, meningitis and measles ...
... IAC for Electronic ClaimsJACKSONVILLE, Fla., April 27 ... today announced that Insurers Administrative Corporation (IAC) has ... compliant electronic claims. As an Availity client, health ... Availity(R) Health Information Network free of charge.(Logo: ...
Cached Medicine News:Health News:AARP to Host Cross-Generational 'Life Festival' in San Antonio May 15-16 2Health News:AARP to Host Cross-Generational 'Life Festival' in San Antonio May 15-16 3Health News:Autism Tied to Older Moms, Breech Birth 2Health News:Autism Tied to Older Moms, Breech Birth 3Health News:Media registration now open for TCT 2009 2Health News:Pennsylvania Secretary of Health Reminds All Parents to 'Be Wise, Immunize Your Children' 2Health News:Insurers Administrative Corporation Joins the Availity Network 2
Wright-Giemsa Stain Solutions...
... For fast, single-solution staining, Hema-Quik ... slides into stain solution for ... to deionized water for five ... second time by dipping quickly ...
... for staining of peripheral blood smears ... stain formulations still in use today. ... of Giemsa stain, although eosinophillic granules ... granules and nuclear chromatin stain a ...
This stain is the McNeal formula and can be substituted for Wright Stain solution....
Medicine Products: