Navigation Links
Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III,Melanoma Demonstrated Significant and Sustained Impact on,Relapse-Free Survival

-- EORTC 18991 Phase III Study Results Presented At ASCO --

CHICAGO – June 2, 2007 – Long-term treatment with pegylated interferon alfa-2b in stage III melanoma had a significant and sustained impact on relapse-free survival (RFS), according to the results of the largest adjuvant trial ever conducted in patients with stage III melanoma. Results of the Phase III study, led by the European Organisation for the Research and Treatment of Cancer (EORTC) and supported by Schering-Plough, were presented today by Alexander Eggermont, M.D., Ph.D. at the 43rd Annual Meeting of the American Society of Clinical Oncology.

“Advanced stage melanoma remains difficult to treat and a need still exists to find treatment options,” said Alexander Eggermont, M.D., Ph.D., lead investigator and head of the department of surgical oncology, Erasmus University Medical Center, Rotterdam, The Netherlands. “These findings demonstrate the benefit of an increased relapse-free survival (RFS) despite no difference in overall survival.”
Median RFS was 34.8 months in the pegylated interferon alfa-2b arm vs. 25.5 months in the observational arm (p-value 0.01). Median distant metastasis-free survival (DMFS) was 45.6 months in subjects receiving pegylated interferon alfa-2b therapy versus 36.1 months in observational arm (p-value 0.11).


The response to therapy appeared to be most pronounced in a subgroup of subjects with only microscopic nodal involvement (patients with positive sentinel node(s) who experienced both increased relapse-free survival (RFS) (p-value 0.02) and distant metastasis-free survival (DMFS) (p-value 0.03). This group of patients constituted
43 percent of the trial population. At present, because of the increased use of sentinel node staging , this patient population largely constitutes the majority of patients diagnosed with stage III disease.'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Anesiva Announces Phase 2 Data Showing Substantial, Long-Term Pain Reductions with Adlea(TM) (formerly 4975) in Osteoarthritis of the Knee
2. Surfaxin (Lucinactant) Long-Term Survival Advantage vs. Comparators Published in Pediatrics
3. Long-Term Extension of Ulcerative Colitis Study Shows Remicade Responders Maintained Improvement Through Two Years of Follow-Up
4. New Long-Term Data Analyses for Bifeprunox Show Favorable Effects Versus Placebo in Stabilized Patients with Schizophrenia
5. Medtronic Updates Long-Term ENDEAVOR I-II Clinical Data Showing Sustained Safety and Significant Reductions in Repeat Procedures
6. Taxus VI Clinical Trial Demonstrates Positive Long-Term Outcomes for Moderate-Release Paclitaxel-Eluting Stent at Four Years
7. UCB Presents Long-Term CImzia Data in Crohns Disease
8. PDL BioPharma Announces Long-Term Nuvion Data Presented at 2007 Digestive Disease Week
9. New Study Results Provide Additional Data about Short- and Long-Term Use of Desvenlafaxine Succinate in the Treatment of Adults with Major Depressive Disorder
10. Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension
11. CEL-SCI Presents Long-Term Cancer Survival Data With Multikine
Post Your Comments:
(Date:6/1/2015)... , June 1, 2015 The nuclear ... by 2020 at a CAGR of 12.08%. Nuclear medicine ... diseases. The two major types of Nuclear imaging used ... was the mainstream modality for nuclear medicine applications like ... to change because of global shortage of molybdenum-99 isotope ...
(Date:6/1/2015)... About Pressure Relief Devices ... and improve the quality life of patients who suffer ... a significant role in inhibiting the growth and treatment ... turn or rotate an immobile patient by providing all ... and specialty beds. These devices have the ability to ...
(Date:6/1/2015)... June 1, 2015 Select Medical Holdings Corporation ... Corporation, a joint venture that Select Medical Corporation ("Select") ... completed its previously announced acquisition of Concentra Inc.  Cressey ... venture. About Select Medical Corporation ... hospitals and outpatient rehabilitation clinics in the ...
Breaking Medicine Technology:North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 2North America Nuclear Imaging Market - Growth, Trends And Forecasts (2014 - 2019) 3Global Pressure Relief Devices Market 2015-2019 2Global Pressure Relief Devices Market 2015-2019 3Select Medical Holdings Corporation Announces Completion of Acquisition of Concentra Inc. through Joint Venture with Welsh Carson 2Select Medical Holdings Corporation Announces Completion of Acquisition of Concentra Inc. through Joint Venture with Welsh Carson 3
... Nov. 3 WebMD Health Corp. (Nasdaq: WBMD ) announced ... to purchase up to 5,700,000 shares of its common stock at ... price per share of WebMD,s common stock on the Nasdaq Global ... The number of shares proposed to be purchased in the tender ...
... , SAN DIEGO, Nov. 3 Robert Mazzacavallo has ... Diego-based Veridiam is a contract manufacturer of high-precision, fabricated ... in the medical devices, power generation, aerospace and general ... Financial Officer at C-Tech Industries in Camas, WA. ...
Cached Medicine Technology:WebMD Health Corp. Announces Intention To Commence Tender Offer To Repurchase Up To 5,700,000 Shares of its Common Stock 2WebMD Health Corp. Announces Intention To Commence Tender Offer To Repurchase Up To 5,700,000 Shares of its Common Stock 3Veridiam Names Robert Mazzacavallo New CFO 2
(Date:6/1/2015)... (PRWEB) June 01, 2015 Hexagon Geospatial ... which is a new cloud-based subscription service that provides ... GIS software. , Both ERDAS IMAGINE and ... through Producer Online, which offers a subscription model for ... organizations need to be able to quickly and easily ...
(Date:6/1/2015)... The session, entitled “Building the Blueprint ... president of Elektrobit Automotive Americas, senior representatives from ... will be moderated by Andy Gryc of CX3 Marketing. ... complexity of in-vehicle software in connected vehicles and autonomous ... how the wider ecosystem can fit into new vehicle ...
(Date:6/1/2015)... CA (PRWEB) June 01, 2015 This ... 2nd Annual GrowRIVERSIDE Conference: The Future of Local Food, ... The conference will assist cities in examining ... and urban agriculture infrastructure. , Organized for the city ... will feature a broad lineup of speakers ranging from ...
(Date:6/1/2015)... If you dread visiting a dentist because ... have some encouraging news. With an idea created by ... San Marcos, Calif., you no longer need to worry. ... Tip to provide improved oral suction needed for dental ... a dental patient’s throat more comfortable by removing excess ...
(Date:6/1/2015)... 01, 2015 Kurbo Health , which ... and teens, announced today it has added in-app chat ... kids and teens to eat smart and reach their healthier ... coaches via text message and phone or video calls, now ... their in-app chat window. For paid users, they will be ...
Breaking Medicine News(10 mins):Health News:Hexagon Geospatial Launches Cloud-Based Producer Online Suite 2Health News:Hexagon Geospatial Launches Cloud-Based Producer Online Suite 3Health News:Elektrobit Automotive, Ford and Delphi to Tackle In-Vehicle Software at TU-Automotive Detroit 2015 2Health News:Elektrobit Automotive, Ford and Delphi to Tackle In-Vehicle Software at TU-Automotive Detroit 2015 3Health News:Limited Tickets Available for “GrowRIVERSIDE” Conference June 11 2Health News:All-in-One Dental Aspirator Invented by InventHelp® Clients (SDB-733) 2Health News:Kurbo, First Mobile Weight Loss Program for Children and Teens, Enhances Coaching with New iOS In-App Chat and Messaging from Coaches 2
... of the hallucinogen psilocybin, the active ingredient in so-called ... personality change lasting at least a year in nearly ... study, according to the Johns Hopkins researchers who conducted ... of the personality known as openness, which includes traits ...
... , WEDNESDAY, Sept. 28 (HealthDay News) -- Cancer patients ... can have serious side effects and even mean the ... crucial that patients insist doctors use plain language ... associate professor of internal medicine at the University of ...
... a patient,s own stem cells, researchers at Johns Hopkins have ... a painful, disabling inherited blood disorder that affects mostly African-Americans. ... cells in a test tube that then turned on a ... cautions that the work, done only in the laboratory, is ...
... Researchers at the Stanford University School of Medicine have ... activation patterns in children with poor reading skills and ... readers with a typical IQ. The work provides more ... difficulties regardless of their general cognitive ability. Schools ...
... large-scale study on cat intestinal cancer has provided new insight ... could ultimately benefit humans. "We are looking for patterns ... risk factors," said Kim Selting, associate teaching professor of oncology ... former resident, Kerry Rissetto, as she examined intestinal tumors in ...
... at the University of California, San Francisco (UCSF) Medical Center ... occurs as healthy brain cells begin to form tumors. ... a common type of brain tumor, at its earliest stage, ... will have to prove safe and effective in clinical trials, ...
Cached Medicine News:Health News:Single dose of hallucinogen may create lasting personality change 2Health News:Single dose of hallucinogen may create lasting personality change 3Health News:Cancer Patients Should Ask Doctors to Use Simple Terms 2Health News:Correcting sickle cell disease with stem cells 2Health News:Stanford brain imaging study shows physiological basis of dyslexia 2Health News:Stanford brain imaging study shows physiological basis of dyslexia 3Health News:University of Missouri study finds risk factors for cat cancer, could have human implications 2Health News:How normal cells become brain cancers 2
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Form: Cream-colored powder Moisture: 10% Ash: 6.5% Gel Strength (1.5%): 550 950 gm/cm 2 Gel pH (1.5%): 6.0 7.5 Gel Point (1.5%): 34 38C Melting Point (1.5%): 84 88C Application: Bacterial ...
An agent used for making solid microbiological media....
... range of miniTHERM incubators is available, ensuring ... solution for their specific requirements. miniTHERM incubators ... compact and extremely space saving. Their size ... It is possible to stack up to ...
Medicine Products: