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Lipitor Provides Unprecedented Cardiovascular Risk Reductions in,Diabetes Patients with Metabolic Syndrome and in Stroke Patients

olesterol and those taking lipid lowering agents, have an LDL level that is higher than recommended in national treatment guidelines. Stroke patients with coronary heart disease are at the greatest risk of cardiovascular events yet are the least likely to be at guideline-recommended LDL levels. The authors suggest that future guidelines for lipid management may require additional revision to reflect the results of newer trials such as SPARCL that support the use of statins in stroke patients without coronary heart disease.

About the Overall CARDS Study

The CARDS study, published in The Lancet in 2004, evaluated patients (n=2,838) with type 2 diabetes who did not have existing cardiovascular disease, but had one or more risk factors for it. Lipitor 10 mg significantly reduced the risk of major cardiovascular events by 37 percent and the risk of stroke by 48 percent compared with placebo.

In CARDS, Lipitor was well-tolerated. The overall frequency of adverse events or serious adverse events did not differ between Lipitor and placebo.

About the Overall SPARCL Study

The SPARCL study, published in the New England Journal of Medicine in 2006, is the only study to date evaluating the benefits of a statin solely in patients with a prior stroke or mini-stroke (n=4,731). Lipitor 80 mg reduced the risk of an additional stroke by 16 percent and major coronary events by 35 percent compared with placebo. In a post-hoc analysis of the SPARCL trial, there was a higher incidence of hemorrhagic stroke in patients taking Lipitor 80 mg compared with patients taking placebo. Patients with prior hemorrhagic stroke at study entry appeared to be at an increased risk of hemorrhagic stroke.

In SPARCL, Lipitor was well-tolerated. The rate of side effects such as elevated liver enzymes, muscle weakness or rhabdomyolysis were low and consistent with the known safety profile.

About Lipitor

Lipitor is the most extensively studied and most pr
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