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Lipitor Provides Unprecedented Cardiovascular Risk Reductions in,Diabetes Patients with Metabolic Syndrome and in Stroke Patients

NEW ORLEANS--(BUSINESS WIRE)--Mar 26, 2007 - Pfizer announced today that Lipitor(R) (atorvastatin calcium) Tablets 10 mg provided a significant 61 percent reduction in stroke in patients with type 2 diabetes and metabolic syndrome but without heart disease. In a separate study, patients who had suffered a recurrent stroke or mini-stroke during the trial had a significant 53 percent reduction in the risk of major coronary events (death from cardiac causes, heart attack, or resuscitation after cardiac arrest) with Lipitor 80 mg. These analyses from two landmark clinical outcomes studies were presented at the annual meeting of the American College of Cardiology.

"What's impressive is the magnitude of cardiovascular efficacy, including a 61 percent reduction in the risk of stroke, that Lipitor offered these patients who were at high risk for cardiovascular events," said Professor John Betteridge, a lead author of CARDS and professor of endocrinology and metabolism at University College London Hospital.

"These results add to the unique and robust body of evidence for Lipitor that includes proven reductions in heart attacks and strokes, impressive average LDL lowering of 39 percent to 60 percent, and an established safety profile across a broad range of patients," said Dr. Michael Berelowitz, senior vice president of Pfizer's global medical division.

New Analysis of the Collaborative Atorvastatin Diabetes Study (CARDS)

In a new analysis of more than 2,200 patients with type 2 diabetes who met the criteria for metabolic syndrome in CARDS:

-- Lipitor 10 mg provided a significant 41 percent reduction in the risk of major cardiovascular events (death from coronary heart disease, heart attacks, strokes, certain types of heart surgery, chest pain) compared with placebo.

-- Lipitor 10 mg provided a significant 61 percent reduction in the risk of stroke compared with placebo.

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