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Lexicon Develops Antibodies That Lower Triglycerides and,Cholesterol as Potential New Therapy for Heart Disease

nt and chief scientific officer at Lexicon and an author on the paper. "The research our team published today may be an important first step in the development of a new treatment for severe cardiovascular disease, which continues to be the leading cause of death in the United States."

Earlier this year, researchers at the University of Texas Southwestern Medical Center in Dallas, the Institute of Molecular Medicine at the University of Texas Health Science Center in Houston, and other collaborating institutions found that individuals with a mutated ANGPTL4 gene have significantly lower triglyceride levels and higher levels of HDL cholesterol (or "good" cholesterol).(1) These results from human genetic studies further support Lexicon's therapeutic strategy based on original observations made using animal models.

Lexicon scientists discovered ANGPTL4's utility as a potential cardiovascular disease target as part of its Genome5000(TM) program, and the discovery was selected for inclusion in its collaboration with Genentech, Inc. The collaboration with Genentech was initiated in December 2002 to discover the functions of secreted proteins and potential antibody targets identified through Genentech's Secreted Protein Discovery Initiative (also referred to as the SPDI program), and was expanded in November 2005 to include the advanced research, development and commercialization of new biologic drugs. Under the collaboration, Lexicon has the right to develop and commercialize biotherapeutic drugs for up to six targets. Genentech retains an option on the potential development and commercialization of the biotherapeutic drugs that Lexicon develops from the collaboration under a cost and profit sharing arrangement. ANGPTL4, referred to internally as LG842, is one of two targets already chosen by Lexicon for internal development. Lexicon has already generated versions of ANGPTL4 monoclonal antibodies that are currently in preclinical evaluation to identify a pote
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