Navigation Links
Late Breaking Data Released at ADA Showed that the Investigational,Use of Januvia and Metformin as Initial Combination Therapy,Provided Significant Glucose Lowering Efficacy over 54 Weeks in,Patients with Type 2 Diabetes

gle 600 mg oral dose of cyclosporine increased the AUC and Cmax of sitagliptin by approximately 29% and 68%, respectively. These modest changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was also not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors. 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility A two-year carcinogenicity study was conducted in male and female rats given oral doses of sitagliptin of 50, 150, and 500 mg/kg/day. There was an increased incidence of combined liver adenoma/carcinoma in males and females and of liver carcinoma in females at 500 mg/kg. This dose results in exposures approximately 60 times the human exposure at the maximum recommended daily adult human dose (MRHD) of 100 mg/day based on AUC comparisons. Liver tumors were not observed at 150 mg/kg, approximately 20 times the human exposure at the MRHD. A two-year carcinogenicity study was conducted in male and female mice given oral doses of sitagliptin of 50, 125, 250, and 500 mg/kg/day. There was no increase in the incidence of tumors in any organ up to 500 mg/kg, approximately 70 times human exposure at the MRHD. Sitagliptin was not mutagenic or clastogenic with or without metabolic activation in the Ames bacterial mutagenicity assay, a Chinese hamster ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, during mating, up to scheduled termination (approximately 8 weeks total) and females were treated 2 weeks prior to mating through gestation day 7. No adverse effect on fertility was observed at 125 mg/kg (approximately 12 times
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32

Related medicine technology :

1. VeroScience Late-Breaking Abstract on Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) Accepted for Poster Presentation at American Diabetes Association 67th Scientific Sessions
2. Pilot Phase 3 Results of NovaCardias KW-3902 for Acute Congestive Heart Failure Presented at Late-Breaking Session of Heart Failure Congress 2007
3. Breaking Multi-Center Study: Masimo SET Pulse Oximetry Technology Shown to Significantly Lower Instances of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants
4. Bentley Late Breaking Abstract Accepted for Poster Presentation at American Diabetes Association Scientific Sessions
5. Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session
6. Everest Data on Short- and Long-Term Use of Otsukas Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACCs Late Breaking Clinical Trials
7. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
8. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
9. Amlodipine and Olmesartan Study Results Released;Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
10. Amlodipine and Olmesartan Study Results Released; Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
11. New Anti-Rejection Medication 6-Month Results for Heart Transplant Recipients to Be Released at International Heart and Lung Transplant Meeting
Post Your Comments:
(Date:9/2/2015)... Sept. 2, 2015 This report on ... current and future prospects of the global market. ... and assists medical practitioners in deciding the treatment ... during treatment. Multi-parameter patient monitoring is effective in ... Geriatric population is observed to be at a ...
(Date:9/2/2015)... , Sept. 2, 2015 About Neuroendovascular ... used to treat an unruptured and ruptured brain ... The treatment is either known as an endovascular ... endovascular coil blocks the blood flow in an ... under general anaesthesia by an interventional neuroradiologist using ...
(Date:9/2/2015)... 2, 2015   About ELISA test ... technologies that is used for measuring the concentration of ... test uses various types of enzymes such as carbonic ... is detected by photometry or fluorometry. ELISA is used ... infectious diseases such as HIV, pernicious anemia, rotavirus, Rocky ...
Breaking Medicine Technology:Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 2Multi-parameter Patient Monitoring Equipment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023 3Global Neuroendovascular Coil Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3
(Date:9/2/2015)... ... September 02, 2015 , ... Since 2011, ... of Atlanta to help support childhood cancer research. On June 17, 2014, ... Radio Care-A-Thon , which is the fund-raising event DoMyOwnPestControl.com sponsors each year. The ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... interim clinical staffing companies, has completed a recapitalization with new investment partners ... BPOC and Heritage Group each offer extensive expertise and connections within the ...
(Date:9/2/2015)... ... ... Every year at this time, students prepare to go back to school. Some ... academic workload confronting them. They just don’t have the skills needed to do their ... how to study. , “Bankers bank. Salesmen sell. Teachers teach. The job of a ...
(Date:9/2/2015)... ... , ... A recent survey by Consumer Reports ( http://bit.ly/1h67tL8 ) sheds light ... on consumers. It was reported that 33% are paying an average of $39 more ... extra $100 compared to last year. Among the drugs that saw the highest increases ...
(Date:9/2/2015)... ... September 02, 2015 , ... World Patent Marketing, a vertically ... safety invention that protects people from crime and other hostile situations. , "The ... CEO and Creative Director of World Patent Marketing. "The industry is growing at ...
Breaking Medicine News(10 mins):Health News:DoMyOwnPestControl.com Goes Gold for Childhood Cancer Awareness Month 2Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 2Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 3Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 4Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 2Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 3Health News:Watertree Health President Responds to Consumer Reports Survey on Rising Prescription Drug Prices 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 4Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 5Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 6Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 7
... , TUESDAY, Dec. 6 (HealthDay News) -- Different molecular mechanisms ... aging of the reproductive system, new research with worms suggests. ... begins to decline after age 35 but other cells in ... later, study author Coleen Murphy of Princeton University said in ...
... (HealthDay News) -- Low levels of vitamin D are much ... obese and are associated with insulin resistance, a risk factor ... included 411 obese children and 87 children who weren,t overweight. ... serum insulin, body mass index and blood pressure. The ...
... rise and 48 percent of all breast cancers occur in ... to have breast reconstruction. A new study from Wake ... after mastectomy is safe for older women. The answer is ... the psychological, social and sexual well-being of the patient, establishing ...
... center and Universit Laval have discovered the likely cause ... more than 10 million North Americans. The team,s promising ... scientific journal Brain . Frequently confused with ... disorder. An estimated 4% of the population over 40 ...
... first-of-its kind study led by Xiao-Cheng Wu, MD, MPH, ... Center New Orleans, reports that a significant number of ... and what factors contribute. The research is published online ... 5, 2011 Early Release section. The research team, which ...
... ( Marmota marmota ) live in extended family groups ... of a dominant territorial pair and a number of ... Over a 14-year period, Klaus Hacklnder of the Institute ... Resources and Life Sciences, Vienna and Walter Arnold of ...
Cached Medicine News:Health News:Research With Worms May Shed Light on Women's Fertility 2Health News:Vitamin D Levels Tied to Diabetes Risk in Obese Kids 2Health News:Advanced age should not deter women from breast reconstruction after cancer 2Health News:LSUHSC research finds many women not receiving recommended breast cancer adjuvant treatment 2Health News:LSUHSC research finds many women not receiving recommended breast cancer adjuvant treatment 3Health News:Hanging with the boys - female Alpine marmots benefit from a bit of pre-natal testosterone 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: