Navigation Links
Late Breaking Data Released at ADA Showed that the Investigational,Use of Januvia and Metformin as Initial Combination Therapy,Provided Significant Glucose Lowering Efficacy over 54 Weeks in,Patients with Type 2 Diabetes

doses of sitagliptin. Clinically meaningful interactions would not be expected with other sulfonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9. However, the risk of hypoglycemia from the co-administration of sitagliptin and sulfonylureas is unknown. Simvastatin: Single-dose pharmacokinetics of simvastatin, a CYP3A4 substrate, was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin. Therefore, sitagliptin is not an inhibitor of CYP3A4-mediated metabolism. Thiazolidinediones: Single-dose pharmacokinetics of rosiglitazone was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin, indicating that JANUVIA is not an inhibitor of CYP2C8-mediated metabolism. Warfarin: Multiple daily doses of sitagliptin did not meaningfully alter the pharmacokinetics, as assessed by measurement of S(-) or R(+) warfarin enantiomers, or pharmacodynamics (as assessed by measurement of prothrombin INR) of a single dose of warfarin. Because S(-) warfarin is primarily metabolized by CYP2C9, these data also support the conclusion that sitagliptin is not a CYP2C9 inhibitor. Oral Contraceptives: Co-administration with sitagliptin did not meaningfully alter the steady-state pharmacokinetics of norethindrone or ethinyl estradiol. Effects of Other Drugs on Sitagliptin Clinical data described below suggest that sitagliptin is not susceptible to clinically meaningful interactions by co-administered medications: Metformin: Co-administration of multiple twice-daily doses of metformin with sitagliptin did not meaningfully alter the pharmacokinetics of sitagliptin in patients with type 2 diabetes. Cyclosporine: A study was conducted to assess the effect of cyclosporine, a potent inhibitor of p-glycoprotein, on the pharmacokinetics of sitagliptin. Co-administration of a single 100 mg oral dose of JANUVIA and a sin
'"/>




Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32

Related medicine technology :

1. VeroScience Late-Breaking Abstract on Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) Accepted for Poster Presentation at American Diabetes Association 67th Scientific Sessions
2. Pilot Phase 3 Results of NovaCardias KW-3902 for Acute Congestive Heart Failure Presented at Late-Breaking Session of Heart Failure Congress 2007
3. Breaking Multi-Center Study: Masimo SET Pulse Oximetry Technology Shown to Significantly Lower Instances of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants
4. Bentley Late Breaking Abstract Accepted for Poster Presentation at American Diabetes Association Scientific Sessions
5. Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session
6. Everest Data on Short- and Long-Term Use of Otsukas Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACCs Late Breaking Clinical Trials
7. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
8. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
9. Amlodipine and Olmesartan Study Results Released;Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
10. Amlodipine and Olmesartan Study Results Released; Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
11. New Anti-Rejection Medication 6-Month Results for Heart Transplant Recipients to Be Released at International Heart and Lung Transplant Meeting
Post Your Comments:
(Date:5/21/2015)... , May 21, 2015 The Pharmaceutical ... regarding the Medicare Part D offsets included in ... initiative: "If the 21st Century Cures initiative ... America,s premier health program – Medicare – then ... yield down the road. "Leveraging payments ...
(Date:5/21/2015)... , May 21, 2015  Today, ... physicians who prescribe biologics – Alliance for ... American College of Rheumatology, Biologics Prescribers Collaborative, ... Organizations, Endocrine Society, and North American Society ... sent a letter to U.S. Food and ...
(Date:5/21/2015)... Research and Markets( http://www.researchandmarkets.com/research/pw67sw/xray_market ) has announced the addition of ... Trends and Forecast 2014 - 2022" report to their ... the largest share of 34.6% of the global X-ray market ... and Europe . North America ... Canada that have a large number ...
Breaking Medicine Technology:Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 2Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 3Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 4X-Ray Market: Global Industry Analysis 2014 - 2022 2
... as a 2010 Company to Watch by the Connecticut ... week in New Haven, Connecticut.  HistoRx was recognized for ... its proprietary AQUA® technology software on a second hardware ... a licensing deal with a national oncology reference lab ...
... Oct. 4 Prognosis Health Information Systems announced ... was certified as a Complete EHR on September ... Information Technology (CCHIT®), an ONC-ATCB, in accordance with ... Secretary of Health and Human Services. The 2011/2012 ...
Cached Medicine Technology:HistoRx Recognized as a 2010 Company to Watch by the Connecticut Technology Council 2Prognosis Health Information Systems' ChartAccess 4.0 Receives ONC-ATCB 2011/2012 Certification 2Prognosis Health Information Systems' ChartAccess 4.0 Receives ONC-ATCB 2011/2012 Certification 3
(Date:5/21/2015)... Charlotte, NC (PRWEB) May 21, 2015 ... regulates the surface temperature of each side of the ... With ChiliPad, users on either side of the bed ... all night, helping them fall asleep faster and stay ... patented system with water to regulate the temperature which ...
(Date:5/21/2015)... New York, New York (PRWEB) May 21, 2015 ... of The Atmananda Yoga Studio and Sequence, is ... popular Atmananda Yoga Matâ„¢, which was previously available for ... The Atmananda Yoga Matâ„¢ unique is that it's ... help prevent serious joint injuries and muscle strains, ...
(Date:5/21/2015)... Mich. (PRWEB) May 21, 2015 Many ... opposite effect on those with celiac disease according to ... than half of the probiotics tested in the study ... foods and dietary supplements and cause gastrointestinal inflammation for ... Companies aiming to gain consumer trust in gluten-free claims ...
(Date:5/21/2015)... Neogenis Labs , a world leader ... been named to the 2015 Austin A-List by the Austin ... by Southwest Interactive. , The A-List companies , selected ... nominations, were officially revealed and named to the annual Austin ... ACL-Live. The 12 honorees for 2015 were named in three ...
(Date:5/21/2015)... New York (PRWEB) May 21, 2015 ... Roslin, MD, Director of Bariatric Surgery at Northern Westchester ... bariatric surgery procedure called Stomach Intestinal Pylorus-Sparing Surgery ... modification to the duodenal switch procedure and benefits patients ... , The Stomach Intestinal Pylorus-Sparing Surgery technique was broadcast ...
Breaking Medicine News(10 mins):Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 2Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 3Health News:NY's Atmananda Yoga Studio Launches Its Patented "Alignment" Yoga Mat for Public Sale 2Health News:Public Health Organization NSF International Offers Solution to Gluten in Probiotics, Dietary Supplements 2Health News:Public Health Organization NSF International Offers Solution to Gluten in Probiotics, Dietary Supplements 3Health News:Public Health Organization NSF International Offers Solution to Gluten in Probiotics, Dietary Supplements 4Health News:Neogenis® Labs Named to 2015 Austin A-List Most Promising Startups 2Health News:Neogenis® Labs Named to 2015 Austin A-List Most Promising Startups 3Health News:Northern Westchester Hospital Surgeon Mitchell Roslin, MD Conducts International Broadcast of Bariatric Surgery Technique 2Health News:Northern Westchester Hospital Surgeon Mitchell Roslin, MD Conducts International Broadcast of Bariatric Surgery Technique 3
... , VISTA, Calif., Aug. 6 Nutritional ... a new marketing campaign touting its flagship, patented nutritional supplement product ... , , The new marketing campaign takes a ... drink enhancer by using a caricature of Albert Einstein at a ...
... , , OLDSMAR, Fla., ... of the largest and most established leaders in stem cell innovation, ... in menstrual blood (known as MenSCs) during the Fourth China Medical ... vitro study show that MenSCs proliferate rapidly and have significant potential ...
... , ( ) , , , ... N.J., Aug. 6 Smart Balance, Inc. (Nasdaq: SMBL ) today announced its ... of $58.2 million, an increase of 21.2% versus year ago, and earnings per share of ... The second quarter net sales increase versus 2008 was due to a 13% ...
... U.S. adults unaware there is no cure, survey finds , ... U.S. adults mistakenly believe that daily medicine can be taken ... that found a widespread lack of knowledge and awareness about ... of 2,148 adults also found that nearly half of respondents ...
... are choosing it for their animal companions , THURSDAY, Aug. ... anymore, as more animal owners are making that choice for ... , For nearly 20 years, a handful of veterinarians has ... kidney failure, to die peacefully at home, not in a ...
... , NASHVILLE, Tenn. and GLEN ... find that 76 percent of surveyed pharmacy directors say ... will have only one preferred biologic for all immune ... ulcerative colitis. According to the new Formulary Forum report ...
Cached Medicine News:Health News:Global Health Trax, Inc. Announces New Marketing Campaign for Oxygen Elements Max Product 2Health News:Cryo-Cell to Present Novel Adult Stem Cell Research During 2009 China Medical Biotech Forum 2Health News:Cryo-Cell to Present Novel Adult Stem Cell Research During 2009 China Medical Biotech Forum 3Health News:Cryo-Cell to Present Novel Adult Stem Cell Research During 2009 China Medical Biotech Forum 4Health News:Smart Balance Announces 2009 Second Quarter Results 2Health News:Smart Balance Announces 2009 Second Quarter Results 3Health News:Smart Balance Announces 2009 Second Quarter Results 4Health News:Smart Balance Announces 2009 Second Quarter Results 5Health News:Smart Balance Announces 2009 Second Quarter Results 6Health News:Smart Balance Announces 2009 Second Quarter Results 7Health News:Smart Balance Announces 2009 Second Quarter Results 8Health News:Smart Balance Announces 2009 Second Quarter Results 9Health News:Smart Balance Announces 2009 Second Quarter Results 10Health News:Food Allergy Facts Need More Focus 2Health News:Hospice Care Eases the End for Loyal Pets 2Health News:Hospice Care Eases the End for Loyal Pets 3Health News:U.S. Payers Intend to Limit Preferred Coverage to Only One Immune Biologic 2Health News:U.S. Payers Intend to Limit Preferred Coverage to Only One Immune Biologic 3
... for Cardiology is the first digital solution ... modalities both within and outside cardiology. From ... the archival solutions, Agfas combined expertise in ... and their customers to work the way ...
Full Digital Ultrasound System...
... Nemio is engineered with the latest technologies ... enhance your clinical insight. These advancements increase ... crisp images that improve visualization of even ... connectivity, you can speed information delivery and ...
This catheter is intended for ultrasound examination of coronary intravascular pathology ONLY. Intravascular ultrasound imaging is indicated in patients who are candidates for transluminal coronary i...
Medicine Products: