Navigation Links
Laquinimod, a Novel Oral Compound, Showed Significant Reduction in,Disease Activity in Patients with Relapsing-Remitting Multiple,Sclerosis (RRMS)

ly oral laquinimod, are very exciting for the MS community--both patients and researchers," said Shlomo Yanai, President and CEO of Teva Pharmaceutical Industries Ltd. "Teva will soon initiate Phase III studies to confirm oral laquinimod's therapeutic benefits, and we expect to begin enrollment of the trial later this year."

About the Study

Study participants were required to have experienced one or more relapses in the year prior to entry and at least one Gd-enhancing lesion at screening. The patients (n=306) in the study were randomized to receive placebo (n=102), 0.3 mg dose of laquinimod (n=98) or 0.6 mg dose of laquinimod (n=106). At entry, active treatment and placebo groups were comparable for demographic, clinical and MRI characteristics.

Patients were assessed clinically and by MRI scan at week -4, baseline, and monthly from weeks 12 to 36. The primary outcome of the study was the cumulative number of Gd-enhancing lesions at weeks 24, 28, 32 and 36. Secondary outcomes of the study included additional MRI metrics and confirmed relapse rate.

The laquinimod 0.6 mg dose showed a reduction compared with placebo in the cumulative number of enhancing lesions per scan in the last four scans (mean SD= 2.6 5.3 vs. 4.2 9.2, p = 0.0048); treatment with the 0.3 mg dose showed no significant difference. Significant differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).

Treatment with both 0.3 and 0.6 mg doses of laquinimod were well tolerated with only some transient and dose-dependent increases in liver enzymes.

About laquinimod

Laquinimod is a novel once-daily, orally administered immunomodulatory compound developed a
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
2. Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science
3. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
6. Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting
7. Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well Tolerated in Phase 3 Study
8. Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
9. Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Societys Annual Meeting
10. Encouraging Clinical Activity of GSKs Novel Cancer Immunotherapeutic Confirmed in Phase II Study in Patients with Most Common Form of Lung Cancer
11. Clinical Data on ARIADs Novel mTOR Inhibitor, AP23573, To Be Presented at the ASCO Annual Meeting
Post Your Comments:
(Date:7/23/2014)... , July 23, 2014 On ... ("Plaintiff") filed suit in the 116 th ... Texas , against RegenLab USA, LLC ... and Prospective Business Relationships through false and ... and, Business Disparagement through libel, disparagement, ...
(Date:7/23/2014)... 2014 Research and Markets   ... Electrophysiology Ablation Catheters Market 2014-2018" report to ... Catheter ablation is a minimally ... electrical pathways from sections of the heart that ... arrhythmias). Cardiac arrhythmias can be of several types, ...
(Date:7/23/2014)... Top Staten Island Pediatrician Dr. Michael Gabriel ... discusses tips for parents about pool safety for children. ... to US News article, "Drowning is the leading ... 1 to 4, and can occur in as little as ... article says that watching a child in the water every ...
Breaking Medicine Technology:Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 2Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 3Premier Staten Island Pediatrician Dr. Michael Gabriel Comments On Article Discussing Pool Safety Tips for Parents 2
... Ill., April 1, 2011 Hospira ... of clinical information and medication delivery technologies, today announced ... system , used by hospitals to help improve patient ... (HAIs). The enhanced TheraDoc system includes new features and ...
... & Dempsey is launching Accountable Care Forum - ... analysis of the emerging accountable care organization (ACO) landscape. ... Centers for Medicare & Medicaid Services (CMS). ... reform legislation affecting physicians and hospitals across the United ...
Cached Medicine Technology:Hospira Launches Enhanced TheraDoc™ Clinical Surveillance System to Support Patient Safety and Help Improve Care 2Hospira Launches Enhanced TheraDoc™ Clinical Surveillance System to Support Patient Safety and Help Improve Care 3Online Forum for Accountable Care Organization Developments Launches Today; Squire Sanders Sponsorship Reflects Commitment to Leadership in Emerging Health Policy Debate 2
(Date:7/23/2014)... a professional company of women’s dresses and related accessories, has ... . Aside from that, it has launched a big promotion ... off. , “We are excited to offer our new collection ... by trustworthy and experienced workers in the fashion field. The ... to provide such a great opportunity for our customers. I ...
(Date:7/23/2014)... York (PRWEB) July 23, 2014 A ... of a power morcellator ( http://www.injurybeacon.com/power-morcellator/ ) during ... other cancers throughout a woman’s body, Bernstein Liebhard LLP ... in the Journal of the American Medical Association, looked ... power morcellator at 500 U.S. hospitals from 2006 to ...
(Date:7/23/2014)... HealthDay Reporter WEDNESDAY, July 23, ... children and teens look in the mirror and tell ... Wednesday. "Being overweight or obese is associated with ... cholesterol and diabetes," said lead researcher Neda Sarafrazi, a ... and Prevention,s National Center for Health Statistics. "Children ...
(Date:7/23/2014)... Home Care Assistance Calgary , ... is proud to announce the next installment in its ... wide range of health and wellness-related fields. The upcoming ... author Nancy Kriseman, and will cover the most common ... by becoming more self-aware. In particular, Nancy will discuss ...
(Date:7/23/2014)... supports a growing body of research suggesting a ... in treating postmenopausal breast cancer, with fewer detrimental ... standard anti-hormone therapies. The study will be published ... Reproductive Biology and Endocrinology . , Breast ... women in the United States. Approximately 70% of ...
Breaking Medicine News(10 mins):Health News:Cheap 2014 Vintage Party Dresses From Professional Supplier iFitDress.com 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 4Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5
... Nov. 9, 2010 New research shows a gene-based ... smokers are most likely to benefit from CT screening ... presented today at the American Association of Cancer Research,s ... In studies that included 1,216 lung cancer cases ...
... clot-busting drug rt-PA remains the most beneficial proven emergency ... an editorial in the November issue of Archives ... of treatment outweigh the risks in patients treated with ... wrote. Biller is chairman of the Department of Neurology ...
... Steven Reinberg HealthDay Reporter , TUESDAY, Nov. 9 ... health insurance for at least part of the past year ... officials reported Tuesday. Those people included not only those ... people, according to a report from the U.S. Centers for ...
... with aromatase inhibitors may experience extremely low estrogen levels ... a typical postmenopausal woman without cancer may not experience. ... in Cancer Prevention Conference, held here Nov. 7-10, 2010, ... increases in side effects such as hot flashes, decreased ...
... N.M. The National Cancer Institute recently announced two ... between the University of New Mexico Cancer Center and ... the creation of a joint Cancer Nanotechnology Platform Partnership, ... new Cancer Nanotechnology Training Center to train a new ...
... , TUESDAY, Nov. 9 (HealthDay News) -- An experiment using ... light on the many ways your mind responds to perceived ... brain are acting to help you survive. These systems are ... how close the threat is to you. Basically, your brain ...
Cached Medicine News:Health News:Research shows gene-based test can prioritize smokers for lung cancer CT screening 2Health News:Research shows gene-based test can prioritize smokers for lung cancer CT screening 3Health News:How well does clot-busting drug work in stroke patients? 2Health News:Number of Uninsured American Adults Hits Record High 2Health News:Number of Uninsured American Adults Hits Record High 3Health News:Side effects of hormonal breast cancer therapy increased; may affect treatment adherence 2Health News:National Cancer Institute awards nearly $4 million to University of New Mexico Cancer Center 2Health News:National Cancer Institute awards nearly $4 million to University of New Mexico Cancer Center 3Health News:Scientists Use Tarantulas to Explore Human Fear 2
... Variable cutting speeds (guillotine movements) are ... when switched off, thus minimizing tissue trauma. ... action, or both can be combined together. ... uni or bi-manual techniques. Lightweight autoclavable hand-pieces ...
...
...
LASIK Retreatment Forceps - Also available in Titanium...
Medicine Products: