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La Jolla Pharmaceutical Announces Positive Interim Antibody Results,From Riquent Lupus Phase 3 Trial

s on 900 mg as 300 mg had a consistent 50% reduction, but no patients on 100 mg or placebo achieved this level of consistent reduction. A consistent reduction is defined as a patient whose percent antibody reduction exceeded a specified level at weeks 4, 6 and 8.

Tolerability

To date, Riquent has been well tolerated in the ongoing Phase 3 study. The adverse event profile for all patients in the study, including those treated with the 300 mg and 900 mg doses, does not appear to differ from that seen in previous studies where 100 mg of Riquent was the treatment dose.

Conference Call

The Company will host a conference call on Thursday, March 8, 2007 at 8:00 a.m. Pacific Time/11:00 a.m. Eastern Time. If you would like to listen to the conference call, please visit La Jolla Pharmaceutical Company's website at www.ljpc.com.

An archived version of the conference call will be available the day of the call at the Company's website www.ljpc.com and will be archived for several weeks. In addition, a replay of the conference call can also be accessed for one week by dialing (888) 286-8010 (US) or (617) 801-6888 (International). The passcode for the replay is 33112152.

These data will be presented at the 8th International Congress on SLE in Shanghai in May 2007.

Phase 3 Study Design

The Phase 3 study is designed to assess the ability of Riquent treatment to prevent or delay the time to renal flare in lupus patients with a history of renal disease and with antibodies to dsDNA. A lupus renal flare is a potentially life-threatening increase in inflammation targeting the kidney. A renal flare often requires treatment with immunosuppressive agents which can have severe side effects.

The global study is expected to enroll approximately 730 patients who will be treated weekly with Riquent or placebo. Equal numbers of pati
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