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Kosan Announces Data Presentations at Upcoming AACR Annual Meeting

HAYWARD, Calif., April 10, 2007 /PRNewswire-FirstCall/ -- Kosan Biosciences Incorporated announced data will be presented on the Company's clinical and preclinical pipeline, including its Hsp90 inhibitor, epothilone and nuclear export inhibitor programs, at the 2007 Annual Meeting of the American Association for Cancer Research (AACR), being held in Los Angeles, April 14-18, 2007.

Poster presentations on Kosan's programs are as follows. The location for all poster presentations is the Los Angeles Convention Center Exhibit Hall.


    Date   Abstract #   Title             Session          Poster  Poster #

                                                           Section

    4/15

    1:00-  1544         Tanespimycin:     Experimental     32      4

    5:00                 No effects on     and Molecular

                         QTC interval      Therapeutics 13

                         using two

                         formulations


    4/15

    1:00-  1568         Preclinical       Experimental     32      28

    5:00                 safety profile    and Molecular

                         of tanespimycin   Therapeutics 13

                         (KOS-5: 953) --

                         a heat shock

                         protein 90

                         (Hsp90)

                         inhibitor


    4/15

    1:00-  1438         KOS-1803: A new,  Experimental     27      19

    5:00                 rationally        and Molecular

                         designed          Therapeutics 8

                         epothilone

                         analog with an

                         improved

                         pharmacological

                         profile and

                         efficacy in

                         xenograft mouse

                         models


    4/18

    8:00-  5597         Anti-tumor        Experimental     29      2

    12:00                activity of       and Molecu
lar

                         novel nuclear     Therapeutics 47

                         export

                         inhibitors

                         (NEIs) in

                         multiple

                         xenograft

                         models


    4/18

    8:00-  5609         Nuclear Export    Experimental     29      14

    12:00                Inhibitors        and Molecular

                         (NEIs) as novel   Therapeutics 47

                         cancer

                         therapeutics


Kosan Biosciences is a biotechnology company advancing two new classes of anticancer agents through clinical development -- Hsp90 (heat shock protein 90) inhibitors and epothilones. Kosan is leveraging its proprietary discovery platform to generate a pipeline of potentially significant product candidates, primarily in the area of oncology.

Hsp90 inhibitors have a novel mechanism of action targeting multiple pathways involved in cancer cell growth and survival. Kosan's proprietary formulation of tanespimycin (KOS-953) is currently in Phase 1 and 2 clinical trials, primarily for multiple myeloma in combination with Velcade(R) (bortezomib) and HER2-positive metastatic breast cancer in combination with Herceptin(R) (trastuzumab). In addition, intravenous and oral formulations of Kosan's second-generation Hsp90 inhibitor, alvespimycin (KOS-1022), are being evaluated in Phase 1 clinical trials.

Epothilones inhibit cell division with a mechanism of action similar to taxanes, one of the most successful classes of anti-tumor agents. KOS-1584 is in Phase 1 clinical trials in patients with solid tumors. Kosan's epothilone program is partnered with Roche through a global development and commercialization agreement.

For additional information on Kosan Biosciences, please visit the company's website at www.kosan .com.

This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 (the "Act"). Such forward-looking statements include but are not limited to statements regarding anticipated presentations of data relating to Kosan's product candidates. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. There are a number of important factors that could cause the results of Kosan to differ materially from those indicated by these forward- looking statements, including, among others, the risks detailed from time to time in the Company's SEC reports, including its Annual Report on Form 10-K for the year ended December 31, 2006 and other periodic filings with the SEC. Kosan does not undertake any obligation to update forward-looking statements.

NOTE: Velcade(R) (bortezomib) is a registered trademark of Millennium Pharmaceuticals, Inc.

Herceptin(R) (trastuzumab) is a registered trademark of Genentech, Inc.

CONTACT: Jane Green, VP, Corporate Communications of Kosan BiosciencesIncorporated, +1-510-731-5335, or mobile, +1-415-652-4819, or green@kosan.com

Web site: http://www.kosan.com/

Ticker Symbol: (NASDAQ-NMS:KOSN)

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1. Kosan Presents Promising Phase 1 Data on Second-Generation Hsp90 Inhibitor, Alvespimycin, Showing Antitumor Activity in Refractory Breast and Ovarian Cancers at ASCO
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