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KineMed Presents Data Measuring Changes in Reverse Cholesterol,Transport for the First Time

Research Breakthrough Will Aid in Developing Therapies to Prevent and Reverse Atherosclerotic Heart Disease

EMERYVILLE, Calif., May 10, 2007 /PRNewswire/ -- KineMed, Inc., a pathway-based drug discovery and development company, announced today the first method for measuring the efflux of cholesterol from tissues in animals through the pathway known as reverse cholesterol transport (RCT). RCT is the only known mechanism by which excess cholesterol can be removed from tissues and has therefore received considerable attention as a therapeutic target for prevention and reversal of atherosclerosis. The data, presented at the Arteriosclerosis, Thrombosis and Vascular Biology Annual Meeting in Chicago, compared the effects of several therapeutic approaches on RCT in real-time, in living animals. KineMed also presented data from its researchers and their collaborators at the University of California, Berkeley and the University of California, San Francisco demonstrating that KineMed's technology successfully measured levels of efflux of cholesterol from the tissues in human subjects.

    The data were presented in posters titled,


    --  "Measurement of Cholesterol Efflux and Global Reverse Cholesterol

        Transport Rates in Vivo with Stable Isotopes", which described in

        detail the proprietary method for measuring the flow of cholesterol

        molecules out of tissues into the bloodstream and then from the

        bloodstream out of the body, and


    --  "Effect of Reconstituted HDL on Cholesterol Efflux from Tissues in

        Vivo".  This poster showed that infusion of CSL-111 (provided by CSL

        Behring AG), which is reconstituted high density lipoprotein (rHDL)

        particles, into animals increased efflux of cholesterol

        out of tissues into the bloodstream.

In addition, data were presented in an invited plenary session talk by Marc Hellerstein M.D., Ph.
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