Navigation Links
KineMed Presents Data Measuring Changes in Reverse Cholesterol,Transport for the First Time

Research Breakthrough Will Aid in Developing Therapies to Prevent and Reverse Atherosclerotic Heart Disease

EMERYVILLE, Calif., May 10, 2007 /PRNewswire/ -- KineMed, Inc., a pathway-based drug discovery and development company, announced today the first method for measuring the efflux of cholesterol from tissues in animals through the pathway known as reverse cholesterol transport (RCT). RCT is the only known mechanism by which excess cholesterol can be removed from tissues and has therefore received considerable attention as a therapeutic target for prevention and reversal of atherosclerosis. The data, presented at the Arteriosclerosis, Thrombosis and Vascular Biology Annual Meeting in Chicago, compared the effects of several therapeutic approaches on RCT in real-time, in living animals. KineMed also presented data from its researchers and their collaborators at the University of California, Berkeley and the University of California, San Francisco demonstrating that KineMed's technology successfully measured levels of efflux of cholesterol from the tissues in human subjects.

    The data were presented in posters titled,


    --  "Measurement of Cholesterol Efflux and Global Reverse Cholesterol

        Transport Rates in Vivo with Stable Isotopes", which described in

        detail the proprietary method for measuring the flow of cholesterol

        molecules out of tissues into the bloodstream and then from the

        bloodstream out of the body, and


    --  "Effect of Reconstituted HDL on Cholesterol Efflux from Tissues in

        Vivo".  This poster showed that infusion of CSL-111 (provided by CSL

        Behring AG), which is reconstituted high density lipoprotein (rHDL)

        particles, into animals increased efflux of cholesterol

        out of tissues into the bloodstream.

In addition, data were presented in an invited plenary session talk by Marc Hellerstein M.D., Ph. D., Co-founder and Chief of the Scientific Advisory Board of KineMed, as well as Professor (Calloway Chair of Human Nutrition), University of California, Berkeley, and Professor of Medicine, University of California, San Francisco. The talk was titled,

    -- "Measuring Reverse Cholesterol Transport and Insulin-Mediated Glucose

       Utilization In Vivo in Animal Models and Humans: Pathway Fluxes as

       Therapeutic Targets". This presentation reviewed the role of

       critical pathways, including RCT, in drug discovery and development.

Dr. Hellerstein stated, "The importance of measuring changes in RCT in the intact animal or patient is highlighted by recent clinical failures in the HDL/atherosclerosis field, which have left a therapeutic void. KineMed's technology can become an integral part of efforts to discover and develop promising agents that treat and reverse atherosclerosis, thereby positioning KineMed as a leader in this field."

RCT is one of the many pathways for which KineMed has the unique technology and IP to measure in intact animals and patients. The RCT technology is currently being used by KineMed and its Pharma partners in preclinical studies as a target for screening candidate compounds, validating target activity, selecting among leads, and optimizing treatment regimes. The Company is also working with Pharma partners in clinical trials to rapidly demonstrate on-mechanism therapeutic effect in patients.

About KineMed, Inc.

KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag(TM) and KineMarker(TM)) to both identify active drug candidates preclinically and confirm their therapeutic activity and dose response in first-in-man studies. KineMed's technology expedites the drug development process and provides real-time insight into conditions including metabolic disorders, cancer, and diseases of infl ammation and neurodegeneration.

KineMed is working to develop drugs both on its own and with pharmaceutical collaborators in therapeutic focus areas where it can demonstrate functional modulation of specific biological pathways that mediate disease. The Company has multiple development programs with more than a dozen major pharmaceutical companies, including Bayer, Merck, Merck KGaA, Organon and Roche.

For further information about KineMed, please visit: http://www.kinemed.com/

CONTACT: Brent Vaughan, Chief Business Officer of KineMed, Inc.,+1-510-655-6525, ext. 110, or media, Justin Jackson of Burns McClellan,+1-212-213-0006, or , for KineMed, Inc. jjackson@burnsmc.com

Web site: http://www.kinemed.com/

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


'"/>




Related medicine technology :

1. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
2. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
3. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
4. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
5. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
6. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
7. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
8. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
9. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
10. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
11. BioCryst Presents Phase I Peramivir Data at the Options for the Control of Influenza Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their ... The patient is doing more than filling out a survey; in many cases health ... increasing emphasis in health care and research on the importance of active engagement with ...
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
Breaking Medicine News(10 mins):