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Keryx Biopharmaceuticals, Inc. Announces Poster Presentations,Highlighting Mechanism of Action and Clinical Activity of,Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American,Diabetes Association 67th Scientific Sessions in Chicago, Illinois

rest include: 2220 - Oral Administration of Sulodexide for the Treatment of Diabetic Nephropathy in a Phase II Study has Minimal to No Effect on Coagulation or Fibrinolytic Activity JULIA LEWIS, ITAMAR RAZ, SHERWYN SCHWARTZ, STEPHEN ARONOFF, MURRAY KATZ, GILBERT EISNER, JAMES MERSEY, Nashville, TN, Jerusalem, Israel, San Antonio, TX, Dallas, TX, Tucson, AZ, Washington, DC, Baltimore, MD 2376 - Efficacy and Safety of Sulodexide in the Treatment of Diabetic Nephropathy RAM WEISS, ROBERT M. NIECESTRO, ITAMAR RAZ, Jerusalem, Israel, New York, NY

ABOUT SULONEX(TM)

Sulonex (sulodexide oral gelcap) belongs to a proposed new class of nephroprotective, or kidney protecting, drugs, known as the glycosaminoglycans. A variety of members of this chemical family have been shown to decrease pathological albumin excretion in diabetic nephropathy in humans. Some of the members of this chemical family include the following approved drugs: standard heparin, low molecular weight heparin and danaparoid. These agents all require therapy by injection and are all potent anticoagulants, which are blood thinners capable of inducing bleeding. Sulonex, on the other hand, is given orally and, in this form, has demonstrated little, if any, anticoagulant effects to date.

Keryx owns the exclusive rights to use Sulonex(TM) for the treatment of diabetic nephropathy in North America, Japan and certain other markets outside of Europe. Diabetic nephropathy is a long-term complication of diabetes in which the kidneys are progressively damaged. Sulonex is a glycosaminoglycan compound with structural similarities to the broad family of marketed heparins and low molecular weight heparins. This drug has been marketed in a number of European, Asian and South American countries for many years by our licensor for certain cardiovascular conditions and has an established safety profile at
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