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Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia

enstrom's Macroglobulinemia: Preliminary Results" demonstrated single agent activity of perifosine with 36% of patients having a PR or MR. Dr. Irene Ghobrial of the Dana-Farber Cancer Institute, who presented the poster, stated, "We are excited at the efficacy and safety results with perifosine in a patient population for which there is no FDA approved therapy. We look forward to reporting updated results at future meetings."

I. Craig Henderson, MD, President of Keryx Biopharmaceuticals, commented "We are very enthusiastic about the potential of perifosine in the treatment of multiple myeloma and Waldenstrom's macroglobulinemia and the prospects of using perifosine to improve upon the current care for these patients."

In addition to the clinical posters, three pre-clinical posters were presented, as follows:

     Perifosine, an Oral Bioactive Novel Akt Inhibitor, Induces In Vitro and

     In Vivo Anti-tumor Activity in Waldenstrom's Macroglobulinemia

      Lead Investigator:   Xavier Leleu, MD, Dana-Farber Cancer Institute,

      Boston, MA


     The Combination of Perifosine with Bortezomib and Rituximab Provides

     Synergistic Anti-tumor Activity in Waldenstrom's Macroglobulinemia

      Lead Investigator:   Xavier Leleu, MD, Dana-Farber Cancer Institute,

      Boston, MA


     Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-

     (Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG) Has

     Synergistic Activity in tumor cell and its microenvironment in Multiple

     Myeloma (MM)

      Lead Investigator:   Alissa Huston, MD, University of Pittsburgh

      Cancer Center


    Copies of all posters can be obtained from Keryx Biopharmaceuticals, Inc.

KRX-0401 (perifosine) is in-licensed by Keryx from Aeterna Zentaris, Inc. in the United States, Canada and Mexico.

ABOUT KRX-0401 (Perifosine)

KRX-0401 (perifosine) is a novel, first-in-class, oral anticancer agent that modulat
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