Navigation Links
Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia

enstrom's Macroglobulinemia: Preliminary Results" demonstrated single agent activity of perifosine with 36% of patients having a PR or MR. Dr. Irene Ghobrial of the Dana-Farber Cancer Institute, who presented the poster, stated, "We are excited at the efficacy and safety results with perifosine in a patient population for which there is no FDA approved therapy. We look forward to reporting updated results at future meetings."

I. Craig Henderson, MD, President of Keryx Biopharmaceuticals, commented "We are very enthusiastic about the potential of perifosine in the treatment of multiple myeloma and Waldenstrom's macroglobulinemia and the prospects of using perifosine to improve upon the current care for these patients."

In addition to the clinical posters, three pre-clinical posters were presented, as follows:

     Perifosine, an Oral Bioactive Novel Akt Inhibitor, Induces In Vitro and

     In Vivo Anti-tumor Activity in Waldenstrom's Macroglobulinemia

      Lead Investigator:   Xavier Leleu, MD, Dana-Farber Cancer Institute,

      Boston, MA


     The Combination of Perifosine with Bortezomib and Rituximab Provides

     Synergistic Anti-tumor Activity in Waldenstrom's Macroglobulinemia

      Lead Investigator:   Xavier Leleu, MD, Dana-Farber Cancer Institute,

      Boston, MA


     Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-

     (Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG) Has

     Synergistic Activity in tumor cell and its microenvironment in Multiple

     Myeloma (MM)

      Lead Investigator:   Alissa Huston, MD, University of Pittsburgh

      Cancer Center


    Copies of all posters can be obtained from Keryx Biopharmaceuticals, Inc.

KRX-0401 (perifosine) is in-licensed by Keryx from Aeterna Zentaris, Inc. in the United States, Canada and Mexico.

ABOUT KRX-0401 (Perifosine)

KRX-0401 (perifosine) is a novel, first-in-class, oral anticancer agent that modulat
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
2. AEterna Zentaris Partner Keryx Presents Phase 1 and Phase 2 Results for Anti-Cancer Compound Perifosine at ASCO Meeting
3. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
4. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
6. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
7. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
8. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study
Post Your Comments:
(Date:3/3/2015)... 3, 2015  Cyberonics, Inc. (NASDAQ: CYBX ... treatment and management of epilepsy, today announced it will ... March 11, 2015, in Miami . ... Chief Executive Officer, will speak at 1:05 PM Eastern ... chat format, and no formal materials will be presented.  ...
(Date:3/3/2015)... March 3, 2015  The eleventh annual Tucson Symposium ... the world,s top research scientists, academics, oncologists and pathologists ... and learn about new outcomes in patient treatments that ... Each year Ventana Medical Systems, Inc. (Ventana), ... the Tucson Symposium at the Hilton El Conquistador in ...
(Date:3/3/2015)... 3, 2015 /CNW/ - ChipCare Corporation, a University of ... for HIV and other infectious and non-communicable diseases ... to bring its first-generation product to market while ... (Photo: http://photos.prnewswire.com/prnh/20150303/179107 ) ... simple, accurate and affordable diagnostic tests makes it ...
Breaking Medicine Technology:Global scientific collaborators to explore latest pathology and oncology advancements at Tucson Symposium 2ChipCare Closes Oversubscribed $5 Million Series A Financing 2ChipCare Closes Oversubscribed $5 Million Series A Financing 3
... 23, 2011 Valeant Pharmaceuticals International, Inc. (the "Company" ... Notice of Intention to make a normal course issuer ... that the TSX has accepted the Notice of Intention. ... to purchase for cancellation, commencing August 25, 2011, 1,000,000 ...
... 2011 Bacterin International Holdings, Inc. (NYSE Amex: ... revolutionary bone graft material and antimicrobial coatings for medical applications, ... Annual Global Investment Conference. The conference will be held at ... 11-13, 2011. Bacterin,s chairman and CEO, Guy Cook, ...
Cached Medicine Technology:Valeant Pharmaceuticals Files a Notice of Intention to Make a Normal Course Issuer Bid 2Valeant Pharmaceuticals Files a Notice of Intention to Make a Normal Course Issuer Bid 3Bacterin International to Present at Rodman & Renshaw Annual Global Investment Conference on September 12, 2011 2
(Date:3/3/2015)... (PRWEB) March 03, 2015 A recent ... confirms what water advocate and radio host Sharon Kleyne ... – lack of sufficient water in the body – ... as 90 percent of the US population. Kleyne further ... a factor in nearly all disease, including aging and ...
(Date:3/3/2015)... WA (PRWEB) March 03, 2015 After ... to a lifestyle of fitness and exercise. Community Health ... article presenting 6 ways that families in Everett, ... during the winter months. , CHC says, “While ... grilled chicken and steamed veggies, many families wonder how ...
(Date:3/3/2015)... N.C. (PRWEB) March 03, 2015 ... pre-hire clinical and health care testing, is now ... its behavioral assessments. The result of acquiring the ... provider, PeopleClues in late 2014, the research will ... be used by hospitals, providers, healthcare staffing organizations ...
(Date:3/3/2015)... MO (PRWEB) March 03, 2015 Extend Nutrition, ... to reduce the amount of calories consumed at the next ... “Snack-2-Health Kit.” There are no lifestyle changes needed and ... 2 snacks per day. , The starter kit contains 60 ... a patented blend of protein, fiber, healthy fat and complex ...
(Date:3/3/2015)... NJ (PRWEB) March 03, 2015 Getting to ... when our health and well-being are at stake. So when ... their ability to move about pain-free – it’s vital to ... of this crucial resource, according to Sridhar Yalamanchili, PT, MSPT, ... , A September 2014 nationwide survey by the ...
Breaking Medicine News(10 mins):Health News:Study linking dehydration and stroke severity supports fresh water advocate’s warnings 2Health News:Study linking dehydration and stroke severity supports fresh water advocate’s warnings 3Health News:6 Wintertime Weight Loss Tips for Family Fitness Presented by Community Health Center of Snohomish County in Recent Article 2Health News:Prophecy Healthcare Acquires IP to Expand Behavioral Benchmarks 2Health News:Prophecy Healthcare Acquires IP to Expand Behavioral Benchmarks 3Health News:Snack Your Way to a Smaller Waistline with Extend Nutrition’s New “Snack-2-Health Kit” 2Health News:Snack Your Way to a Smaller Waistline with Extend Nutrition’s New “Snack-2-Health Kit” 3Health News:Separating Fact from Fiction about Physical Therapy 2Health News:Separating Fact from Fiction about Physical Therapy 3
... it was found that the chest circumference records are beating ... it was found that better nutrition was the main reason. ... that the average chest circumference of Chinese women has increased ... This change was seen only from early 1990s. ...
... most Americans prefer a sandbag workout when compared to a ... brought into focus the latest in fitness craze across the ... a comparable load to what workers of the construction site ... to ‘heave-ho their way to fitness’ by moving around heavy ...
... DTNBP1 that appears to influence human intelligence. This ... manipulation techniques to enhance an individual's intellectual skills. ... of individuals afflicted with schizophrenia; a disorder marked ... with those of normal individuals. This lead to ...
... directed at B-cells could turn out be more effective ... disease arising out of an auto immune disorder.// ... form of biologic therapy for treatment of rheumatoid arthritis ... patients who exhibit resistance to conventional DMARDs. The effect, ...
... researchers at Columbia University Medical Center to analyze the ... cancer treatment, //it has been found that nearly one ... specifically, stage III colon cancer patients who were prescribed ... were found to stop their treatment before completion. ...
... Many of Britain’s workers frequently report sick due to ... to 3000 people develop// occupational asthma every year. Prolonged ... trigger occupational asthma. ,Alveolitus or 'occupational asthma’ is ... an allergic inflammation of the lung. It is ...
Cached Medicine News:Health News:Human Intelligence Gene Identified By Scientists 2Health News:B-Cell Biologic Therapy Could Revolutionize Rheumatoid Arthritis Treatment 2Health News:B-Cell Biologic Therapy Could Revolutionize Rheumatoid Arthritis Treatment 3Health News:Colon Cancer Death Rate Doubles As Patients Stop Chemotherapy 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: