( Data presented at the 11th Internationa...)Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia,Health

Data presented at the 11th International Myeloma Workshop held in Kos, Greece demonstrates clinical activity of perifosine in combination with bortezomib, dexamethasone and lenalidomide plus dexamethasone, in patients with relapsed/refractory multiple myeloma, and as a single agent in patients with relapsed/refractory Waldenstrom's macroglobulinemia

NEW YORK, June 29, 2007 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. today announced that 4 posters were presented at the 11th International Myeloma Workshop demonstrating the clinical activity of KRX-0401 (perifosine) in patients with advanced multiple myeloma and Waldenstrom's macroglobulinemia.

Perifosine is currently being evaluated in 3 ongoing, multi-center clinical studies for patients with relapsed or relapsed/refractory multiple myeloma, including in combination with dexamethasone, in combination with Velcade(R) (bortezomib) and in combination with Revlimid(R) (lenalidomide) plus dexamethasone. Perifosine is also being evaluated in an ongoing phase II single agent study in patients with relapsed and/or refractory Waldenstrom's macroglobulinemia. Data from each of these ongoing studies was presented during the conference and demonstrates perifosine's activity, both as a single agent and as part of a combination, in patients with multiple myeloma and Waldenstrom's macroglobulinemia.

Perifosine in the treatment of Patients with Relapsed/Refractory Multiple Myeloma:

In a poster entitled "A Multicenter Phase I/II Trial of Perifosine (KRX- 0401) + Bortezomib in Relapsed and Refractory Multiple Myeloma in Patients Previously Treated with Bortezomib: Preliminary Results", Dr. Paul Richardson, Clinical Director of the Jerome Lipper Multiple Myeloma Center at the Dana- Farber Cancer Institute in Boston, MA reported an overall response rate (partial response (PR) + minimal response (MR)) of 31%. In 16 evaluable patients treated with pe
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