Navigation Links
Karo Bio Announces Sucessfule Phase II Results of KB2115

HUDDINGE, Sweden,11-Jun-2007 / Karo Bio (STO:KARO) successful KB2115 Phase II study meets primary objectives. The 12 week proof of concept phase II study with KB2115 in patients with dyslipidemia has been successfully completed. KB2115 is efficacious in LDL lowering and safe with respect to a broad range of parameters reflecting effects on heart, bone, muscle and thyroid function.

The thyroid hormone receptor (TR) is a key regulator of metabolic pathways and holds the promise of a new target for the treatment of dyslipidemia. KB2115 is an innovative and first in class liver selective agonist for the TR. Unlike the natural thyroid hormones, KB2115 is a liver selective TR agonist that can induce pharmacological effects in the liver, while a normal thyroid state is preserved in the rest of the body.

The completed 12 week, placebo controlled, double blind, randomised, clinical phase II study in 99 patients with high cholesterol levels was designed to explore whether a clinically relevant LDL-cholesterol lowering effect can be achieved without affecting the heart, bone, muscle and thyroid function.

The study demonstrated that a pronounced and clinically relevant lowering of LDL cholesterol can be obtained while preserving the thyroid homeostasis outside the liver and biomarkers for heart, bone, muscle and other organs were kept at normal levels. The mild increase in liver enzymes that was picked up in the previous 2-week phase I trial, was observed in this study as well, however, it seems to be a transient and benign effect. In addition to the positive result regarding efficacy and safety it was also shown that the enteric coating of KB2115 was effective in protecting the compound from chemical modification in the stomach.Thereby, a safety concern for longer exposure in man is removed.

The specific results from the KB2115 phase II study will be presented at upcoming international conferences dur
'"/>




Page: 1 2 3

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Karo Bio Announces Sucessfule Phase Results
(Date:11/26/2014)... DALLAS , November 25, 2014 ... Surgical Instruments Market by Power Source (Electric, Battery, ... Console, Cables, Blade, Burr, Cart), by Application (Orthopedic, ... 2019" published by MarketsandMarkets, the global Powered Surgical Instruments ... to $1.6 Billion in 2014 and is expected ...
(Date:11/26/2014)... 2014 Reinforcing its commitment to enabling confident ... PHG AEX: PHIA) today announced 510(k) clearance ... its IQon Spectral CT , presenting an entirely ... adds a new dimension to Computed Tomography (CT) imaging, ... structures based on their material content within a single ...
(Date:11/26/2014)... 2014   Heska Corporation (NASDAQ: HSKA ... provider of advanced veterinary diagnostic and other specialty veterinary ... Chair, will attend The Benchmark Company, LLC,s Micro Cap Discovery ... be held at The Palmer House Hilton, 17 E. Monroe ... to 2:30 p.m. Please email hska@haydenir.com or contact ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3Heska to Attend Benchmark Micro Cap Discovery Conference 2
... GLEN BURNIE, Md. , Jan. 14 ... provider of prescription medications and veterinary therapeutic and ... Pet Nutrition, Inc. ("Hill,s"), a subsidiary of Colgate-Palmolive ... expand its reach to veterinarians and pet owners ...
... , , , ... January 14 QualiSystems today announced,the release of TestShell ... management. Resource Manager is the,latest module in the award-winning TestShell ... TestShell Resource Manager ( http://tinyurl.com/ResMngr ) is a ...
Cached Medicine Technology:VetCentric Partners With Hill's Pet Nutrition 2VetCentric Partners With Hill's Pet Nutrition 3QualiSystems TestShell now Maximizes Test Lab Resource Management 2QualiSystems TestShell now Maximizes Test Lab Resource Management 3
(Date:11/26/2014)... Maryland (PRWEB) November 26, 2014 ... accepting submissions for the tenth annual MEDA Awards, ... economic development excellence in Maryland. “The MEDA Awards ... economic prosperity to the state. We encourage our ... that are making a positive economic impact in ...
(Date:11/26/2014)... November 26, 2014 Increasing demand ... include image guided surgeries has paved way for ... Rising incidence of various types of cancers and ... increase in demand for these owing to their ... contrast media injectors market can also be attributed ...
(Date:11/26/2014)... November 26, 2014 German scientists say ... science can cause mesothelioma that looks and acts similar ... new article on the research. Click here to ... Institute for Toxicology and Experimental Medicine in Hannover injected ... all of the rats eventually developed mesothelioma , ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 For its ... independently published The AIS Report on Blue Cross and ... WellPoint, Inc. on the varied strategies the two Blues ... improve compliance with treatments for sleep apnea, ranging from ... disorder, because it’s linked to increased rates of a ...
(Date:11/26/2014)... With Thousand Oaks cosmetic dental work ... the Anacapa Dental Art Institute in Woodland Hills and Oxnard, ... for some. , That is why they offer a variety ... “No dentist wants cost to come between a patient and ... Mamaly Reshad, partner in the Anacapa Dental Art Institute. “That’s ...
Breaking Medicine News(10 mins):Health News:Maryland Economic Development Association Seeking Submissions for 2015 Awards 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 4Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 5
... THURSDAY, Oct. 6 (HealthDay News) -- Indoor tanning beds may be ... New research published online Oct. 6 in the Journal of ... used in tanning beds -- UVA1 -- may penetrate to a ... changes caused by UV rays. The new study ...
... genes turn on and off at the wrong times, proteins ... of control. Even a cancer cell,s metabolism goes haywire, as ... them to generate energy. One particular piece of cellular machinery ... is a group of proteins called mTORC1. This master control ...
... News) -- More than 28,000 cases of injury and illness ... in the United States between 2002 and 2008, according to ... at private homes, and the most common problems were respiratory ... The findings are based on projections from a nationally representative ...
... The U.S. Food and Drug Administration and the National ... study of tobacco users to monitor and assess the ... The initiative, called the Tobacco Control Act National ... NIH/FDA collaboration on tobacco regulatory research since Congress granted ...
... you live could play a larger role in health ... by researchers from the Johns Hopkins Bloomberg School of ... neighborhood in Baltimore, Maryland and found that, with the ... obesity among women and use of health services disappeared ...
... is entering the next phase of a multi-million, multi-institutional ... an individual,s level of exposure to radiation in the ... The project will enter a $5 million contract option ... by the U.S. Department of Health and Human Services, ...
Cached Medicine News:Health News:Tanning Beds May Be Even Riskier Than Thought 2Health News:Tanning Beds May Be Even Riskier Than Thought 3Health News:How cells sense nutrients and fuel cancer cell growth 2Health News:FDA and NIH announce joint study on tobacco use and risk perceptions 2Health News:Place, not race, may be a larger determinant of health disparities 2Health News:ASU embarks on next phase of an effort to rapidly assess radiation dose 2
... The new Finnpipette Focus from ... to combine ergonomics with uncompromising ... handle plate offers a custom ... The new shorter tip cones ...
... pipette is ideal for repeated ... Fixed volume FInnpipettes offer the ... other Finnpipette Digital pipettes: ... (1-40ul), Soft-touch tip ejection, Safety ...
This fixed-volume digital micropipet is used to accurately measure and transfer 5 microliters of solution....
5L...
Medicine Products: