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Investigational Study Evaluates the Effectiveness of Aripiprazole,in Adolescents With Schizophrenia

ignificant differences between aripiprazole and placebo were observed from baseline (aripiprazole 10 mg: 0.5; aripiprazole 30 mg: 0.3; placebo: -0.3) on the Simpson-Angus Scale (SAS) which measures signs and symptoms of Parkinsonism.

In this 6-week study, the percentage of patients on aripiprazole with greater than or equal to 7 percent increase in baseline body weight was 4 percent for aripiprazole 10 mg, 5.2 percent for aripiprazole 30 mg, and 1 percent for placebo. The mean change from baseline in weight was zero for aripiprazole 10 mg group; 0.2 kg (about 0.4 lbs) for the aripiprazole 30 mg group, and -0.8 kilograms (kg), or about 1.8 lbs, for placebo group.

Average prolactin levels were decreased relative to baseline in all treatment groups (10 mg aripiprazole, -12 ng/mL; 30 mg aripiprazole, -17 ng/mL, placebo, -9 ng/mL).

About Aripiprazole

Aripiprazole is indicated for the treatment of schizophrenia including maintaining stability in adults who had been symptomatically stable on other antipsychotic medications for periods of three months or longer and observed for relapse during a period of up to 26 weeks. Aripiprazole is also indicated for the treatment of acute manic and mixed episodes associated with Bipolar I Disorder, and for maintaining efficacy in adults with Bipolar I Disorder with a recent manic or mixed episode who had been stabilized and then maintained for at least six (6) weeks. Physicians who elect to use aripiprazole for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual. Aripiprazole Injection is indicated for the treatment of agitation in adults with schizophrenia or bipolar disorder, manic or mixed.

Initially approved in November 2002, over 10 million prescriptions have been written for aripiprazole in the U.S.(3)

Aripiprazole is available by prescription only. Aripiprazole is available in tablets, orally disintegrating tablets, oral solution, and
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