In a research paper entitled "SCHISANDRIN B PROTECTS AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURY BY ENHANCING MYOCARDIAL GLUTATHIONE ANTIOXIDANT STATUS"; Yim and Ko; Molecular and Cellular Biochemistry 1999; 196: 151-156, Professor Dr. Robert Ko published the beneficial effects of Schisandrin B, the precursor of (-) Schisandrin B - a novel discovery by Dr. Ko - on Ischemic Heart Disease.
Ischemic heart disease (IHD) is the major cause of death in most industrialized countries. Following the removal of blood clot in the coronary artery, reperfusion of the previously blood-deprived myocardium can cause additional tissue damage. This phenomenon of ischemia-reperfusion (I-R) injury is an important cause of heart dysfunction and eventually death in patients suffering from IHD. Agents that offer heart protection against I-R injury is therefore of great therapeutic value in the prevention and treatment of IHD.
Schisandrin B, an active ingredient from Schisandra Berry, a well-known cardio-tonic in traditional Chinese medicine, has been shown to possess antioxidant properties. This investigation aims to examine whether Schisandrin B can protect against I-R injury in the heart. The results demonstrate for the first time cardio-protection afforded by Schisandrin B against I-R injury BY ENHANCING MYOCARDIAL GLUTATHIONE ANTIOXIDANT STATUS. In contrast, Dimethyl Diphenyl Bicarboxylate (DDB), an anti-hepatitis drug with a similar chemical structure to Schisandrin B, does not produce any cardio-protective effect or enhance tissue antioxidant status. This bespeaks much of the unique ability of Schisandrin B to e nhance the free radical scavenging capacity of the heart, thereby protecting against I-R injury.
The finding, which is corroborated by empirical evidence of the Schisandra berry as cardio-tonic in Traditional Chinese Medicine for hundreds of years, supports the use of Schisandrin B in the prevention and treatment of IHD.
Since the publication of this finding, Dr. Ko has identified an isomer of Schisandrin B, (-) Schisandrin B, a novel discovery, which possesses a more potent pharmacological profile than that of Schisandrin B. Patented use of this newly discovered compound, (-) Schisandrin B, for the prevention and treatment of Ischemic Heart Disease has been applied for with the US Patent and Trademark Office.
For a copy of this research report, please contact the publisher, Molecular and Cellular Biochemistry.
About the Company
MitoPharm Corporation is a biotechnology company in the research & development, marketing and sale of drugs, dietary supplements, and functional beverages. The initial products are based on a newly discovered compound (the "Compound") that is the result of over 15 years of research and development by one of its founding shareholders, the Hong Kong University of Science and Technology ("HKUST"). MitoPharm believes that its products have the potential to play a significant role in addressing the aging concerns of the baby boomers, the heart-health and heart-diseases markets, and the segment of the population that is physically active. www.mitopharm.com
At HKUST, scientific studies have identified biochemical actions of MitoPharm's key Compound, demonstrating that it enhances the mitochondrial glutathione antioxidant status, a crucial factor in maintaining mitochondrial function and cell survival, and also induces the expression of heat shock proteins, another group of important molecules for cell protection. Management's research indicates that these biochemical actions differentiate the Compound f rom other existing, known compounds, either synthetic or naturally occurring, in its ability to protect organs including the heart, the liver, and the brain. www.ust.hk.com
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