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Investigation Findings, Corroborated by Empirical Evidence of the,Schisandra Berry as Cardio-Tonic in Traditional Chinese Medicine,for Hundreds of Years, Support the Use of Schisandrin B in the,Prevention and Treatment of IHD

SEATTLE--(BUSINESS WIRE)--May 29, 2007 - Mitopharm Corporation, Inc. (Pink Sheets:MTPM), releases the results of a research paper where Professor Dr. Robert Ko published the beneficial effects of Schisandrin B, the precursor of (-) Schisandrin B - a novel discovery by Dr. Ko - on Ischemic Heart Disease.

In a research paper entitled "SCHISANDRIN B PROTECTS AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURY BY ENHANCING MYOCARDIAL GLUTATHIONE ANTIOXIDANT STATUS"; Yim and Ko; Molecular and Cellular Biochemistry 1999; 196: 151-156, Professor Dr. Robert Ko published the beneficial effects of Schisandrin B, the precursor of (-) Schisandrin B - a novel discovery by Dr. Ko - on Ischemic Heart Disease.

Ischemic heart disease (IHD) is the major cause of death in most industrialized countries. Following the removal of blood clot in the coronary artery, reperfusion of the previously blood-deprived myocardium can cause additional tissue damage. This phenomenon of ischemia-reperfusion (I-R) injury is an important cause of heart dysfunction and eventually death in patients suffering from IHD. Agents that offer heart protection against I-R injury is therefore of great therapeutic value in the prevention and treatment of IHD.

Schisandrin B, an active ingredient from Schisandra Berry, a well-known cardio-tonic in traditional Chinese medicine, has been shown to possess antioxidant properties. This investigation aims to examine whether Schisandrin B can protect against I-R injury in the heart. The results demonstrate for the first time cardio-protection afforded by Schisandrin B against I-R injury BY ENHANCING MYOCARDIAL GLUTATHIONE ANTIOXIDANT STATUS. In contrast, Dimethyl Diphenyl Bicarboxylate (DDB), an anti-hepatitis drug with a similar chemical structure to Schisandrin B, does not produce any cardio-protective effect or enhance tissue antioxidant status. This bespeaks much of the unique ability of Schisandrin B to e
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