Navigation Links
Introgen's Advexin Demonstrates Clinical Benefit in Inherited,Cancer

roof of the principle for the therapeutic application of targeted ADVEXIN therapy in tumors with p53 abnormalities that are among the most common and fundamental molecular defects in cancer," said Neil Senzer, M.D., Scientific Director, Mary Crowley Medical Research Center, and lead author of the article. "ADVEXIN's mechanism of action is targeted to restoring p53 tumor suppressor function that is abnormal in Li-Fraumeni tumors and in many other types of cancer."

ADVEXIN is being developed for European markets by Gendux AB, a subsidiary of Introgen Therapeutics, Inc. The European Medicines Agency (EMEA) has designated, and the European Union has confirmed, ADVEXIN p53 therapy as an Orphan Drug for the treatment of LFS. A Letter of Intent to the EMEA regarding Marketing Authorization Application for the approval of ADVEXIN to treat LFS was filed under the Exceptional Circumstances Approval procedures in the EU.

Collaborators on this publication included clinicians from Mary Crowley Medical Research Center, Sammons Cancer Center, Baylor University Medical Center, The Royal Marsden Hospital NHS Foundation Trust, Imperial College London Hammersmith Campus, and the Institute of Cancer Research in the United Kingdom.

About Li-Fraumeni Syndrome

Approximately 400 families are affected by LFS annually. The majority of LFS families contain mutations in the p53 tumor suppressor gene. Affected individuals often develop multiple primary tumors, which typically occur at a young age. Conventional therapy of patients with the Li-Fraumeni Syndrome is frequently unsuccessful due to the occurrence of multiple malignancies that share a common p53 genetic defect fundamental to cancer progression and the development of treatment resistance. Defects in p53-mediated cell death pathways cause these tumors to develop resistance to standard therapy, resulting in early death. Additionally, because affected individuals lack p53-mediated DNA repair function, treatment
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Preclinical Studies Identify Novel Approach for Enhancing the Anticancer Activity of Introgens INGN 241
2. Introgen Reports Updated Phase 2 Advexin Data Correlating Improved Survival, Tumor Responses and Predictive p53 Biomarker
3. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
4. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
5. New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines
6. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
7. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
8. Frova Phase III Study Data Demonstrates That Short-Term Prevention Treatment Reduces Frequency and Severity of Menstrual Migraine
9. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
10. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
11. Prostate Cancer: Clinical Study Demonstrates Superior Efficacy of Docetaxel Chemotherapy
Post Your Comments:
(Date:1/15/2014)... , Jan. 15, 2014 Tegra Medical is very pleased ... as its new Chief Executive Officer.  Mark was promoted ... he has overseen the company,s four facilities in ... Rica.  Mr. King joined Tegra Medical in 2012 with 20+ ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium Research ... market intelligence, the United States ... device markets will expand moderately through 2022, with ... In particular, increasing interest in drug-eluting beads (DEBs) ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ...
Breaking Medicine Technology:Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... YORK, Jan. 19, 2012 Berkery Noyes, an independent ... Year Mergers and Acquisitions trend report for ... The report analyzes the sector ... 2009 and 2010. This market includes information and technology ...
... Associates is among just five workplaces to appear on ... For" since the rankings debuted three decades ago.  The ... earned the No. 38 spot on the 2012 list, ... ) Headquartered in Newark, Del., Gore employs ...
Cached Medicine Technology:Berkery Noyes Releases 2011 Pharma & Healthcare Information and Technology Industry Mergers & Acquisitions Report 2Berkery Noyes Releases 2011 Pharma & Healthcare Information and Technology Industry Mergers & Acquisitions Report 3W. L. Gore & Associates Named a Top U.S. Workplace 2
(Date:4/18/2014)... (Seattle, WA April 18, 2014) Benaroya Research ... to research how blocking a particular molecule in metastatic ... and the number of lung metastases. BRI scientists have ... protein can shrink tumors by 60 - 80 percent ... to the lung. The $1.8 million five-year grant comes ...
(Date:4/17/2014)... of chronic inflammation in benign prostate tissue was ... this association was found even in those with ... study published in Cancer Epidemiology, Biomarkers & ... for Cancer Research. , An analysis of prostate ... placebo arm of the Prostate Cancer Prevention Trial ...
(Date:4/17/2014)... published today in PLOS Pathogens , children who ... common can mount an immune response to infection with ... bouts of high fever and illness and partially control ... findings may help researchers develop future interventions that prevent ... , Each year, approximately 200 million cases of malaria ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... (April 16, 2014) The cause of neuronal death ... study proposes that neurons may be mistaken for foreign ... similar to the way autoimmune diseases like type I ... cells. The study was published April 16, 2014, in ... and likely controversial, idea in Parkinson,s disease; but if ...
Breaking Medicine News(10 mins):Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Is Parkinson's an autoimmune disease? 2
... WASHINGTON, Aug. 27 The YWCA USA joins the ... political force who worked tirelessly for nearly five decades to advance ... pieces of legislation that helped to improve the lives of all ... a champion of issues of critical importance to the YWCA," said ...
... ... Hawaii -- October 20-24, 2009, Hawaii Convention Center , ... Bethesda, MD (Vocus) August 27, 2009 -- The world,s top scientists ... latest research findings at the 59th Annual Meeting of the American Society of Human ...
... ST. PAUL, Minn., Aug. 27 / PRNewswire/ ... mobile computer workstation that enables office workers to move from ... they wish - reducing back strain, increasing productivity and burning ... , The new WorkFit workstation helps employees ...
... found link between muscle strength, arthritis woes , THURSDAY, Aug. ... women, but not men, from the pain of arthritic knees, ... common joint affected by osteoarthritis or degenerative joint disease, a ... In the United States, nearly 27 million adults suffer from ...
... , , , NEW YORK, Aug. 27 ... l pt, Inc. , is pleased to announce the airing ... infomercial to air the new technology of laser assisted liposuction. , ... for the patient with a quicker, easier recovery; the patient can virtually go ...
... , CHARLES TOWN, W.Va., Aug. 27 ... electronic treatments for the pain resulting from peripheral neuropathy and ... its second quarter 09 profits and that profits are up ... (Logo: http://www.newscom.com/cgi-bin/prnh/20061128/REBUILDERLOGO ) , , ...
Cached Medicine News:Health News:YWCA USA Mourns the Death of Senator Kennedy 2Health News:The American Society of Human Genetics Hosts 59th Annual Meeting 2Health News:The American Society of Human Genetics Hosts 59th Annual Meeting 3Health News:The American Society of Human Genetics Hosts 59th Annual Meeting 4Health News:The American Society of Human Genetics Hosts 59th Annual Meeting 5Health News:New WorkFit Ergonomic Workstations From Ergotron 'Take a Stand' for 21st Century Office Computing 2Health News:New WorkFit Ergonomic Workstations From Ergotron 'Take a Stand' for 21st Century Office Computing 3Health News:Strong Thighs May Mean Less Knee Pain for Women 2Health News:Strong Thighs May Mean Less Knee Pain for Women 3Health News:ReBuilder Medical Technologies, Inc. Announces Second Quarter 2009 Profits up 100% 2
The most compact revolutionary innovation in hematology. 26 parameters with 5 Part DIFF...
... stand-alone microprocessor-controlled photometer designed to measure the ... single- or dual- wavelength reading modes. Fast ... reading range up to 4.0 OD allow ... assay requirements. Self-diagnostics (up to 8 quality ...
... System is made up of three integral ... and the Merci Balloon Guide Catheter. The ... location of the clot has been identified ... is inserted through a small incision in ...
A 3080/3085 orthopedic extension serves as a mobile, radiolucent orthopedic platform. When not in use, accessories can be removed and stored in cart....
Medicine Products: