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Introgen's Advexin Demonstrates Clinical Benefit in Inherited,Cancer

Case History Highlighted in AACR Cancer Journal

AUSTIN, Texas--(BUSINESS WIRE)--May 30, 2007--Introgen Therapeutics, Inc. (NASDAQ:INGN) announced today the publication of data describing the dramatic clinical benefit of its lead product Advexin in a patient with a rare inherited form of cancer known as Li-Fraumeni Syndrome (LFS), a genetic disorder characterized by inherited mutations in the p53 tumor suppressor gene. This is the first reported treatment of Li-Fraumeni tumors with a therapy targeted to the underlying molecular cause of the disorder. These cancers are due to inherited abnormalities of p53 function which is directly addressed by ADVEXIN treatment. In addition, the results of the study evaluated biomarkers which confirmed the molecular mechanism of activity of ADVEXIN. These biomarkers will guide ADVEXIN therapy of other cancers with p53 abnormalities, which is one of the most common molecular defects found in virtually all types of cancer.

The patient was treated as part of a study at the Mary Crowley Medical Research Center in Dallas, TX and the importance of the findings were underscored by publication this week in the Spotlight on Clinical Response editorial highlights section of the current issue of Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

ADVEXIN treatment of a tumor in an LFS patient led to improvement of tumor-related symptoms and resulted in a complete response as determined by positron emission tomography (PET) scans. In addition, molecular biomarker studies using tumor biopsies before treatment detected abnormal levels of p53 protein predictive of ADVEXIN efficacy. Tumor biopsies analyzed after therapy identified restoration of p53 tumor suppressor function including suppression of tumor growth and induction of tumor cell death validating ADVEXIN's mechanisms of action.

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