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Introgen Reports Promising Phase 1/2 Clinical Results With INGN 241,in Patients With Advanced Solid Tumors

vely kills cisplatin-resistant cells when used as monotherapy, and restores cisplatin sensitivity. Cisplatin is one of the most commonly utilized treatments for lung, breast and colon cancers. However, development of cisplatin resistance is a common event and the ability of INGN 241 to kill these resistant tumors and restore cisplatin efficacy has important clinical implications. Previous INGN 241 preclinical studies have indicated similar synergies with other chemotherapies and with radiation treatment.

Dr. Chada added, "These preclinical data demonstrate that INGN 241 can restore sensitivity to cisplatin, a widely used chemotherapy drug that frequently gives rise to resistance. Our findings support applications of INGN 241 in combination with standard chemotherapy and radiation regimens and we are planning future clinical trials based on these results."

About INGN 241

INGN 241 is being tested in a Phase 2 clinical trial for patients suffering from advanced melanoma and in a Phase 3 clinical trial in combination with radiation therapy in solid tumors. The mda-7 gene is the active component of INGN 241 and was discovered in the laboratory of Dr. Paul B. Fisher, professor of clinical pathology at Columbia University. Introgen holds an exclusive worldwide sublicense to the Columbia University rights for all gene therapy applications from GlaxoSmithKline.

About Introgen

Introgen Therapeutics, Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted molecular therapies for the treatment of cancer and other diseases. Introgen is developing molecular therapeutics, immunotherapies, vaccines and nano-particle tumor suppressor therapies to treat a wide range of cancers using tumor suppressors, cytokines and genes. Introgen maintains integrated research, development, manufacturing, clinical and regulatory departments and operates multiple manufacturing facilities including a commercial scale
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