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International Movement Disorder Specialists Receive New Information,About the Use of Once-Daily Azilect in the Treatment of Parkinson's,Disease

323) of the total 1,361 patients (24%) were noted to have taken a concomitant antidepressant, including amitriptyline, sertraline, paroxetine, trazodone, and citalopram. No apparent cases of serotonin toxicity (ST) occurred. Symptoms that occurred more frequently with the combination of AZILECT plus antidepressant could be accounted for as being symptoms of either antidepressant use or of depression.

"Rates of termination of treatment were similar, with and without antidepressants, further supporting the relative safety of AZILECT(R) (rasagiline tablets) combined with antidepressants," said Dr. Panisset. "Twenty four percent of the total number of AZILECT treated PD patients were also taking antidepressants. Seeing this apparent lack of serotonin toxicity is important."

According to the US prescribing information the exposure during development, both in dose and number of subjects was not adequate to rule out the possibility of an untoward reaction from combining AZILECT with antidepressants. Other MAO-B inhibitors are labeled similarly.

About AZILECT(R)

AZILECT is indicated for the treatment of the signs and symptoms of Parkinson's disease (PD) both as initial therapy alone and to be added to levodopa later in the disease. The effectiveness of AZILECT was shown in patients with early PD who were receiving AZILECT as initial therapy alone and who were not receiving any other PD therapy. The effectiveness of AZILECT as adjunct therapy was shown in patients with PD who were treated with levodopa.

    -- You should not take AZILECT if you are currently taking meperidine as

       it could possibly result in a serious reaction such as coma or death.

    -- You should not take AZILECT with tramadol, methadone, propoxyphene,

       dextromethorphan, St. John's wort, mirtazapine, or cyclobenzaprine.

    -- You should not take AZILECT with other monoamine oxidase inhibitors

       (MAOIs), amphetamines, cold remedies containing dec
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