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Interim Results Presented at EASL from PROVE 1 Clinical Trial of,Investigational Drug Telaprevir in Patients with Genotype 1,Hepatitis C

aceutical research and development company. Tibotec is dedicated to the discovery and development of innovative HIV/AIDS drugs and anti-infectives for diseases of high unmet medical need. The Company's main research and development facilities are in Mechelen, Belgium with offices in Yardley, PA.

For further information on Tibotec, please visit www.tibotec.com

Safe Harbor Statement

This press release my contain forward-looking statements, including statements that (i) PROVE 1 data support potential to shorten treatment duration and increase SVR rates in patients with genotype 1 HCV infection; (ii) 12 weeks of telaprevir-based therapy enabled some patients to clear the virus; (iii) high SVR rates with telaprevir may be achieved with regimens that are no longer than 24 weeks in duration; (iv) interim results support our approach to evaluating telaprevir-based regimens of differing durations in our Phase 2 program; (v) the information from PROVE 1 and PROVE 2 will allow us to design optimized durations and regimens for Phase 3 development; (vi) the PROVE studies are expected to provide information to optimize treatment duration and treatment regimen for telaprevir-based therapy; (vii) Vertex will consider evaluation of treatment regimens that would include telaprevir in combination with peg-IFN and RBV, and depending on PROVE 2 data, regimens that may exclude RBV; (viii) Vertex expects to focus on treatment durations of no more than 24 weeks; and (ix) Vertex and Tibotec are planning to meet with regulatory authorities to discuss the Phase 3 design in mid-2007 and are planning to initiate Phase 3 clinical development in the fourth quarter of 2007. While management makes its best efforts to be accurate in making forward-looking statements, such statements are subject to risks and uncertainties that could cause the actual results of studies to vary materially. Those risks and uncertainties include, among other things, the risk that observed outcomes in
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