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Interim Analysis of Crinone Pregnancy Study to Be Published in,American Society for Reproductive Medicine Journal

LIVINGSTON, N.J.--(BUSINESS WIRE)--Jun 25, 2007 - Columbia Laboratories, Inc. (NASDAQ: CBRX) announced today that an interim analysis of a pregnancy study comparing the efficacy of CRINONE(R) 8% (progesterone gel) to compounded intramuscular progesterone (IMP) injections is now available online and will be published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine (ASRM).

This ongoing prospective randomized controlled study is evaluating pregnancy rates and successful long-term pregnancies in 400 women treated with CRINONE 8% progesterone vaginal gel versus compounded progesterone intramuscular injections. The study is being conducted by the Brigham and Women's Hospital in Boston.

The interim analysis compared pregnancy rates and patient preferences among 215 patients who had completed 20 weeks of pregnancy. Patients were randomized to receive CRINONE 8% (n = 105) or IMP (n = 110). Pregnancy rates, implantation rates, and early spontaneous abortion rates were similar in both arms of the study, whereas fewer side effects and greater overall satisfaction were reported by women receiving CRINONE 8%.

"The fact that CRINONE 8% delivers the progesterone needed to achieve and maintain pregnancy has been widely established in numerous clinical studies. This study by Brigham and Women's Hospital is also evaluating patient satisfaction, which is increasingly important given the trend toward patients taking a more active role in deciding their treatment regimens," stated Robert S. Mills, president and chief executive officer of Columbia Laboratories.

"The interim analysis shows women receiving CRINONE 8% reported fewer side effects and greater overall satisfaction versus women receiving IMP. This comes as no surprise, considering their differences. The IMP is administered as a deep intra-muscular injection, with injection site pain and potential irritation and
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