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Interferon Beta DNA Treatment Delivered with Ichor Technology,Reduces Atherosclerosis Progression in Mice

Summary: Proprietary DNA delivery technology enables sustained Interferon-beta production from muscle cells - reduces atherosclerosis progression in mouse model of heart disease

NEW ORLEANS--(BUSINESS WIRE)--Mar 26, 2007 - Research conducted at Cleveland Clinic and presented today at the American College of Cardiology's 58th Annual Scientific Session showed that a single administration of DNA encoding the anti-inflammatory protein interferon-beta (IFN-beta) using Ichor Medical System's TriGrid Delivery System (TriGrid) reduced the development of plaque formation in a mouse model of atherosclerosis.

"The sustained production of this protein reduced the atherosclerotic lesion size and tissue-damaging inflammation that characterize the blood vessels of these mice with atherosclerosis," said Marc S. Penn, M.D., Ph.D., principal investigator from Cleveland Clinic.

While preliminary, these results broaden the support for the use of the electroporation-based TriGrid as an enabling platform technology to provide continuous endogenous production of therapeutic proteins from a patient's own muscle. Previous studies done in collaboration with Dr. Vince Tuohy's lab at Cleveland Clinic demonstrated that one-time delivery of the IFN-beta gene intramuscularly with the TriGrid in a mouse model of multiple sclerosis (MS), resulted in sustained production of IFN-beta and a similar reduction in the severity of clinical disease as compared to a separate group of mice dosed every other day with recombinant IFN-beta (Molecular Therapy 14(3): 416-422 (2006)). This study suggests that in vivo gene transfer of the IFN-beta gene may provide a convenient and viable alternative to constant life-long dosing of the recombinant form of IFN-beta for patients with MS.

Together, these data demonstrate both the potential therapeutic and economic value of Ichor's technology.

"The TriGrid platform makes treatments like
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