Navigation Links
Interferon Beta DNA Treatment Delivered with Ichor Technology,Reduces Atherosclerosis Progression in Mice

Summary: Proprietary DNA delivery technology enables sustained Interferon-beta production from muscle cells - reduces atherosclerosis progression in mouse model of heart disease

NEW ORLEANS--(BUSINESS WIRE)--Mar 26, 2007 - Research conducted at Cleveland Clinic and presented today at the American College of Cardiology's 58th Annual Scientific Session showed that a single administration of DNA encoding the anti-inflammatory protein interferon-beta (IFN-beta) using Ichor Medical System's TriGrid Delivery System (TriGrid) reduced the development of plaque formation in a mouse model of atherosclerosis.

"The sustained production of this protein reduced the atherosclerotic lesion size and tissue-damaging inflammation that characterize the blood vessels of these mice with atherosclerosis," said Marc S. Penn, M.D., Ph.D., principal investigator from Cleveland Clinic.

While preliminary, these results broaden the support for the use of the electroporation-based TriGrid as an enabling platform technology to provide continuous endogenous production of therapeutic proteins from a patient's own muscle. Previous studies done in collaboration with Dr. Vince Tuohy's lab at Cleveland Clinic demonstrated that one-time delivery of the IFN-beta gene intramuscularly with the TriGrid in a mouse model of multiple sclerosis (MS), resulted in sustained production of IFN-beta and a similar reduction in the severity of clinical disease as compared to a separate group of mice dosed every other day with recombinant IFN-beta (Molecular Therapy 14(3): 416-422 (2006)). This study suggests that in vivo gene transfer of the IFN-beta gene may provide a convenient and viable alternative to constant life-long dosing of the recombinant form of IFN-beta for patients with MS.

Together, these data demonstrate both the potential therapeutic and economic value of Ichor's technology.

"The TriGrid platform makes treatments like
'"/>




Page: 1 2 3

Related medicine technology :

1. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
2. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
3. New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective Relative to Other Interferon Therapies for Multiple Sclerosis
4. Idenix Reports Results from Two Phase IIb Studies of the Combination of Valopicitabine and Pegylated Interferon in Hepatitis C Genotype-1 Patients at the 42nd Annual Meeting of the European Association for the Study of the Liver
5. Intarcia Therapeutics Announces Final Results From a Phase 2 Study of Injectable Omega Interferon plus Ribavirin for the Treatment of Hepatitis C Genotype-1
6. First Pharmacoeconomic Analysis with Long-Term Data Showed Copaxone Was More Cost-Effective Than Interferon Beta Therapies for Treatment of Relapsing-Remitting Multiple Sclerosis (RRMS)
7. Helix BioPharma Corp. Announces Positive Phase II Clinical Results with its Topical Interferon Alpha-2b
8. Point of Care Strep Tests Speed Treatment, Lower Costs
9. Rapid HIV Testing Increases Possibility of Treatment
10. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
11. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
Post Your Comments:
(Date:4/28/2015)... We are living a connected life in a ... and very soon we will be able to connect our ... life market has been valued by Frost & Sullivan at ... drive and manage this change to stay ahead of the ... Highlights of the congress include a groundbreaking keynote address showcasing ...
(Date:4/27/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ... amniotic tissue and patent-protected processes to develop and ... Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and ... results for the first quarter of 2015. ... decision of its Board of Directors to authorize ...
(Date:4/27/2015)... BOSTON , April 27, 2015   Intarcia ... $225 million synthetic royalty financing with an equity conversion ... to use these funds to accelerate the initiation of ... vs. leading oral and injectable type 2 diabetes therapies. ... expected infrastructure and talent required to launch ITCA 650 ...
Breaking Medicine Technology:Frost & Sullivan's GIL 2015 Unveils the $700 Billion Connected Life Market 2Frost & Sullivan's GIL 2015 Unveils the $700 Billion Connected Life Market 3MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 2MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 3MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 4MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 5MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 6MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 7MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 8MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 9MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 10MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 11MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 12MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 13MiMedx Announces Record Results for First Quarter of 2015 and raises full-year guidance 14Intarcia Therapeutics Closes Novel $225 Million Synthetic Royalty Financing With Equity Conversion Option At $5.5 Billion Valuation 2Intarcia Therapeutics Closes Novel $225 Million Synthetic Royalty Financing With Equity Conversion Option At $5.5 Billion Valuation 3
... at Society of NeuroInterventional Surgery ... ... results from,the US and Argentina reveal that a new minimally invasive ... condition that, in severe form, can cripple sufferers.,Announced today at the ...
... represents newest alternative surgical ... treatment, Dr. Carl Giordano - based in Morristown ... ... quicker recovery, MORRISTOWN, N.J., July 29 Leading New Jersey orthopedic,surgeon Dr. Carl ...
Cached Medicine Technology:New Minimally Invasive Surgical Procedure Restores Quality of Life in Patients With Potentially Debilitating Spinal Condition 2New Minimally Invasive Surgical Procedure Restores Quality of Life in Patients With Potentially Debilitating Spinal Condition 3NJ-Based Surgeon Helps Pioneer Dramatic Advance in Treating Damaged Discs 2
(Date:4/28/2015)... Louis, Missouri (PRWEB) April 28, 2015 ... report that delves into the reality problem Americans have ... the population will need long-term care services as they ... need such care. , In the report, Carol ... organizations such as the American Health Care Association and ...
(Date:4/28/2015)... Once considered an unproven alternative to HID lighting, the ... storm with perfectly tailored light spectrums in an ideal, low ... than half of every SuperCloset and SuperRoom sold are now ... is gone and LED Grow Lights are here to stay. ... their first hand experience using the new LED Grow lights ...
(Date:4/28/2015)... Omaha, NE (PRWEB) April 28, 2015 ... federal district are among the top areas that healthcare ... Medical Group, aureusmedical.com, during the month of March 2015. ... which specializes in travel nurse jobs , ... hire positions within nursing and allied health fields. ...
(Date:4/28/2015)... April 28, 2015 PREVENT Life Safety, ... announced the relocation of their Southern California offices from ... 9380 7th Street, Unit I (letter I), Rancho Cucamonga, ... relocation was necessitated by the significant growth the company ... California. PREVENT will continue to provide superior life safety ...
(Date:4/27/2015)... Healthcare marketing specialists Smith & ... “Website Anatomy 101.” Available for download at ... elements for a successful hospital website. , ... experience, search results and lead generation strategy, healthcare ... website on patient volume and retention. This white ...
Breaking Medicine News(10 mins):Health News:SeniorCare.com Report: America Has a Major Misconception on Aging 2Health News:SuperCloset Reports Surge in KIND LED Grow Light Sales, Saving Indoor Growing Enthusiasts up to 40% on their Power Usage. 2Health News:Hot States for Medical Careers: Healthcare Staffing Agency Aureus Medical Releases Online Search Results 2Health News:PREVENT Life Safety Moves to New Office in Rancho Cucamonga 2Health News:Smith & Jones Publishes 2015 Website Design White Paper 2
... pharmaceutical community, VIENNA, Va., Feb. 11 ... http://www.convera.com, a leading provider of vertical,search ... of,PharmaLiveSearch.com, a vertical search site specific to ... with Canon,Communications Pharmaceutical Media Group., ...
... of Directors as Chairman, NASHVILLE, Tenn., Feb. ... General Atlantic LLC (General,Atlantic) and affiliates of Hellman ... interests in Emdeon held by HLTH Corporation (Nasdaq:,HLTH). ... from HLTH in,November 2006., Emdeon also announced ...
... #1 FOR IMMEDIATE RELEASE , Recordable ... , Move over, compact discs, DVDs, and hard drives. ... protein-based memory device that could provide an alternative to ... approaching their memory storage capacities. Their study is scheduled ...
... Corporation,of America (Nasdaq: DCAI ) announced the ... Delaware County, Ohio which began construction,late last year, ... Everett commented, "Our newest facility in Ohio,opened earlier ... zero,deficiencies. The facility is in partnership with physicians ...
... to complementary or alternative medicine may not be accurate, ... -- Just 5 percent of Web pages devoted to ... complementary or alternative medicine are 15 times more likely ... a new study says. , Moreover, standard measures of ...
... to improve,prostate cancer imaging, WASHINGTON, Feb. 11 ... the Department of Health and Human,Services (HHS) and ... high priority" in the current for research and ... treatment of prostate,cancer. Such a federal investment in ...
Cached Medicine News:Health News:Convera(R) and Canon Communications Launch PharmaLiveSearch.com 2Health News:Convera(R) and Canon Communications Launch PharmaLiveSearch.com 3Health News:General Atlantic and Hellman & Friedman Purchase HLTH Corporation's Remaining Interest in Emdeon 2Health News:General Atlantic and Hellman & Friedman Purchase HLTH Corporation's Remaining Interest in Emdeon 3Health News:General Atlantic and Hellman & Friedman Purchase HLTH Corporation's Remaining Interest in Emdeon 4Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 2Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 3Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 4Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 5Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 6Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 7Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 8Health News:American Chemical Society's Weekly PressPac -- Feb. 6, 2008 9Health News:Dialysis Corporation of America Announces Opening of New Dialysis Center in Ohio 2Health News:Most Breast Cancer Web Pages Contain Reliable Information 2Health News:U.S. Representatives Urge Critical Improvements in Prostate Cancer Detection 2Health News:U.S. Representatives Urge Critical Improvements in Prostate Cancer Detection 3Health News:U.S. Representatives Urge Critical Improvements in Prostate Cancer Detection 4
Corning 7078A multi-pack plugged capacity 5 mL...
Calibrated"to deliver"with blow-out, andpacked in a flip-top canister to keep the pipets racked. Feature: subdivision 0.1 mL volume 5.0 mL...
Corning 7077B L 215 mm volume 5.0 0.1 mL...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z37,160-2) ... assistance. Color: colour-coded ...
Medicine Products: