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Intercell AG: Novel tuberculosis Vaccine Shows Promising,Immunogenicity and Safety Profile

» The Danish Statens Serum Institut (SSI) and Intercell report promising data
from a phase I clinical trial with a tuberculosis (TB) subunit vaccine

» The vaccine is produced by SSI and contains Intercell’s adjuvant IC31™

» The project which is supported by the European Union aims to either
replace the available TB vaccine “BCG”/“Calmette vaccine” or to
boost its activity in adults.

COPENHAGEN, Vienna, March 14, 2007 – Statens Serum Institut (SSI) and Intercell announced today that their collaborative novel tuberculosis (TB) vaccine is safe and very immunogenic in healthy individuals in a phase I clinical trial. The preliminary data will be presented on the Keystone Symposia on Tuberculosis in Vancouver, March 24, 2007 by Prof. Peter Andersen from the SSI and April 12, 2007 at the 3rd Vienna Vaccines Conference by co-investigator Prof. Tom Ottenhoff, Leiden University Medical Center, Netherlands. Based on these results the partners will initiate a clinical trial with latent TB-infected and BCG-vaccinated individuals later in 2007.

The new H1 vaccine from SSI is a recombinant subunit vaccine based on two important TB antigens resulting from SSI’s research pipeline combined with Intercell’s proprietary adjuvant IC31™. The phase I clinical trial was performed at the Department of Infectious Diseases (headed by Prof. Jaap van Dissel) at Leiden University Medical Center in the Netherlands and was supported by the European Union–funded program “TB-VAC”.

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