Navigation Links
InterMune Presents Research on ITMN-191 in Hepatitis C at Digestive,Disease Week Meeting

observed with covalent protease inhibitors currently in development. The immediate onset of inhibition and slow dissociation observed with ITMN-191 suggest that liver concentrations may underestimate its antiviral activity, since ITMN-191 will likely remain bound to the protease target after unbound drug is cleared from the liver."

About ITMN-191

Preclinical toxicology and pharmacokinetic studies in multiple species suggest that ITMN-191 has attractive characteristics, including significant liver exposure, slow dissociation from the NS3/4 protease, high in vitro potency and specificity, and an advantageous cross-resistance profile, including considerable effectiveness against variants of the NS3/4A protease that are resistant to other HCV protease inhibitors currently in development. The preclinical pharmacokinetic results support the exploration of twice-daily oral dosing. In early May 2007, InterMune reported that it had completed dosing in a Phase 1a single ascending-dose (SAD) trial of ITMN-191 in healthy subjects. No serious adverse events were reported in the SAD trial. Preliminary safety data from the SAD trial suggests that ITMN-191 was well tolerated and safe at the doses intended for the Phase 1b multiple-ascending dose (MAD) trial of ITMN-191. InterMune currently anticipates that the MAD trial will begin in the third quarter of 2007 and initial top-line viral kinetic data reported in the fourth quarter of 2007. InterMune and Roche have a collaboration agreement for the research, development and commercialization of ITMN-191 (referred to as R7227 within the Roche research and development programs) and second-generation HCV protease inhibitor compounds.

About HCV and HCV Protease Inhibitors

According to the Centers for Disease Control and Prevention (CDC), an estimated 3.9 million Americans (1.8%) have been infected with HCV, of whom 2.7 million are chronically infected. It is estimated that there are 170 million people worldwid
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. InterMune Presents Research on ITMN-191 in Hepatitis C at EASL Annual Meeting
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
(Date:10/1/2014)... 1, 2014   Royal Philips (NYSE: ... its eCareCoordinator and eCareCompanion telehealth applications have received ... Administration (FDA). A part of Philips Hospital to ... and eCareCompanion are focused on patient care within ... to be available through the cloud-based digital health ...
(Date:10/1/2014)...  CVS Health is thanking its 26,000 pharmacists during ... the way health care is delivered to increase access, ... pharmacies, mail service pharmacies and specialty pharmacies nationwide.  ... to CVS Health to reflect our broader health care ... to shape the future of health," said Larry ...
(Date:9/30/2014)... Sept. 30, 2014 /CNW/ - Protecting the health and safety of ... Canada uses the appropriate powers and tools at its disposal to ... and quality standards. To that end, Health ... the import into Canada of all drug ... They are: , Apotex Pharmachem India Pvt Ltd ...
Breaking Medicine Technology:Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2
... 24 PulmoBioTech Inc. (OTC,Bulletin Board: PLMO) announced today ... that it will be investigating as part of the,Regulatory ... 1. Efficacy Binding Studies 2. Characterization of ... Pyrogenicity 5. Immunological Testing 6. Dosimetry ...
... PALO ALTO, Calif., April 24 CV Therapeutics,Inc. ... Committee for Medicinal,Products for Human Use (CHMP) of ... opinion recommending approval of ranolazine in the,European Union ... Following this positive recommendation from the CHMP, CV ...
Cached Medicine Technology:PulmoBioTech Announces Details of Its Regulatory Approval Experiments 2PulmoBioTech Announces Details of Its Regulatory Approval Experiments 3European Medicines Agency Adopts Positive Opinion for Ranolazine for Treatment of Chronic Angina 2European Medicines Agency Adopts Positive Opinion for Ranolazine for Treatment of Chronic Angina 3
(Date:10/1/2014)... Marriagelifeinsurance.com has released a new blog post explaining ... , Senior citizens can purchase a joint life insurance ... A joint policy is cheaper, but will only pay ... Life insurance can be used to cover important funeral ... online, as the application process is simple and straightforward. ...
(Date:10/1/2014)... 01, 2014 Bedros Keuilian is not ... Camp fitness boot camps, he’s also considered the leading ... with sold out business summits, a line of high-demand ... to a recent Spike TV reality show to his ... is the time for personal trainers and fitness business ...
(Date:10/1/2014)... First Warning Systems, a pioneer in ... throughout the body, announced the company is changing its ... company’s breadth of upcoming product releases. The initial focus ... , “Our initial focus will be an ‘Internet of ... circadian cellular changes over time,” said Rob Royea, president ...
(Date:10/1/2014)... 01, 2014 T.E.N., a ... relationship-marketing firm, announced today the nominees vying ... Project of the Year Awards for North ... organizations in financial services, commercial, health care, ... endeavors that address key issues in the ...
(Date:10/1/2014)... Join the more than 80 golfers who already have ... charity golf tournament to benefit Project HEAL, a not-for-profit organization ... afford treatment. The tournament will be held Monday, Oct. 6, ... The day-long event starts with 10:30 a.m. check-in and shotgun ... begin at 5 p.m. and will include an auction featuring ...
Breaking Medicine News(10 mins):Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3
... science at high school has just become a little more ... from the University of Bath have found that a protein ... a cell divides in two. , In research published in ... shown that the protein is essential for building the microtubules ...
... of The Walter and Eliza Hall Institute, Professor Suzanne ... of the 2008 Thomson Scientific Citation Awards announced at ... Scientific, a US-based international information analysis company, states that ... that identifies the average number of citations per paper ...
... Heart Associations Los Angeles Division today will honor John ... in use around the country and one of the ... Harbor-UCLA Medical Center (LA BioMed). , The association will ... Criley and William Koenig, Los Angeles County Emergency Medical ...
... site heralds AAGL commitment to patient education, ... professional,organization of gynecologists interested in endoscopy and minimally,invasive ... and added a,comprehensive patient education section on ... to treat them. The site,continues to provide physician ...
... ... WHITE PLAINS, N.Y., April 3, 2008 Head lice is ... common,cold.(1) There are about 6 to 12 million cases each year,(2) ... days annually.(3),But, now parents can say good-bye to head lice and ...
... April 3, 2008 Mach One,Corporation, http://www.machonecorp.com, ... prior to large scale manufacturing of its ImmunoGam(TM),colostrum ... highly qualified scientist from BioQual spent a week ... technology transfer and,memorializing the protocols for manufacture of ...
Cached Medicine News:Health News:Mitosis gets harder thanks to new gene discovery 2Health News:Professor Suzanne Cory honored with national citation award 2Health News:Pioneer of paramedic model to be honored 2Health News:Pioneer of paramedic model to be honored 3Health News:Women Can Now Learn About Minimally Invasive Gynecologic Treatments at AAGL.org 2Health News:Women Can Now Learn About Minimally Invasive Gynecologic Treatments at AAGL.org 3Health News:Women Can Now Learn About Minimally Invasive Gynecologic Treatments at AAGL.org 4Health News:New Breakthrough Treatment is Tough On Lice But Gentle On Kids 2Health News:New Breakthrough Treatment is Tough On Lice But Gentle On Kids 3Health News:Mach One Corporation Announces Completion of Final Tests Prior to Full Scale Production 2
Suture Cutters, Straight...
Suture scissor...
Threaded cannula for use with Suretac® II, sterile packs, box of 10....
The Small Oval Cannula System is designed to be the smallest oval cannula system currently available, and is utilized with the Caspari Suture Punch System. Disposable seals are available with this sy...
Medicine Products: