Navigation Links
Insmed Releases Positive Results from Iplex Phase II HIV-Associated,Adipose Redistribution Syndrome Clinical Study

RICHMOND, Va.--(BUSINESS WIRE)--Apr 30, 2007 - Insmed Inc., (Nasdaq:INSM) today announced positive results from a Phase II investigator-sponsored clinical study of the company's drug IPLEX(TM) in HIV-infected patients affected with HIV-associated Adipose Redistribution Syndrome (HARS).

Preliminary results from the study, being conducted at the University of California, San Francisco, showed that three months of 0.5 mg/kg/day IPLEX treatment in seven patients increased IGF-I levels 3-fold and was associated with significant improvements in fasting glucose levels, the amount of insulin secreted during an oral glucose tolerance test, and overall insulin sensitivity. Moreover, there was a significant reduction in trunk fat and a positive downward trend in waist circumference when compared to baseline. Lipid profiles also tended to improve.

Notably, normal glucose tolerance was restored in half of the six patients diagnosed with impaired glucose tolerance (IGT) at the start of the study. These IGT patients also experienced a significant decrease in visceral adipose tissue (VAT). Impaired glucose tolerance is characterized by blood glucose between 140 and 200 mg/dl at the 120-minute measurement of an oral glucose tolerance test. The next phase of the study is underway to explore an IPLEX dose of 1.0 mg/kg/day given for six months.

"Our study has demonstrated that a low dose of IPLEX increased IGF-I levels 3-fold and positively impacted abnormal glucose metabolism, dyslipdemia and abnormal fat distribution, which are present in a significant number of HIV patients treated with highly active antiretroviral therapy (HAART)," said Morris Schambelan, M.D., the study's principal investigator and professor of medicine and director of the General Clinical Research Centers at University of California, San Francisco, and chief of endocrinology at San Francisco General Hospital.

"We are very encouraged by t
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Insmed Inc. to Present at C.E. Unterberg, Towbin Growth Conference
2. Insmed Inc. Welcomes Studies Linking IGFBP-3 to Prevention of Blindness in Premature Infants
3. Insmed Announces Promising Results From IPLEX Phase II Myotonic Muscular Dystrophy Clinical Study
4. State of Diabetes in Pittsburgh: Pittsburgh Business Group on Health Releases Report
5. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
10. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
11. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
Post Your Comments:
(Date:9/22/2014)... Sept. 22, 2014 Paragon 28, ... commercial launch of its foot plating system that supplants ... The GORILLA TM R3CON PLATING SYSTEM greatly enhances ... TM & Mini-Monster TM Screw Systems and ... of 10 interchangeable subsystems, the GORILLA TM R3CON ...
(Date:9/22/2014)... 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... comprehensive and up-to-date publication available covering the neurotechnology industry. ... markets, competitors, and growth rates in four key segments ... 2018. It forecasts the number of systems to be ...
(Date:9/22/2014)... , Sept. 22, 2014  Elusys Therapeutics, Inc. ... treat infectious disease, today announced it has completed ... of obiltoxaximab (ETI-204). Obiltoxaximab is an anti-toxin in ... data from these studies support the safety and ... at the intended therapeutic dose. The conclusion of ...
Breaking Medicine Technology:Paragon 28, Inc. Launches the GORILLA(TM) R3CON PLATING SYSTEM 2The Market for Neurotechnology: 2014-2018 2Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 2Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 3Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 4Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 5Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 6
... 20 Muscadine grape skin powder, from ... /), provided significant protection against radiation damage in an ... reported in April of 2009 at the 100th Annual ... Denver, Colorado.(Logo: http://www.newscom.com/cgi-bin/prnh/20090420/CL01715 )The ...
... prototype 3D display exceeds performance expectations.LIVONIA, Mich., April 20 ... Heritage Hospital surgeons and their medical support team assembled to ... test the new LifeVision(TM) family of 3D technologies developed by ... event marks the first time in history that ...
Cached Medicine Technology:Muscadine Grape Skin Dietary Supplement Protects against Cancer Therapy Radiation Side Effects 2Oakwood Surgeons Perform World's First 3D Surgery Without Special Glasses 2Oakwood Surgeons Perform World's First 3D Surgery Without Special Glasses 3Oakwood Surgeons Perform World's First 3D Surgery Without Special Glasses 4
(Date:9/23/2014)... 23, 2014 Visiting Nurse Association (VNA) ... health care, hospice and palliative care, and community-based care ... Opening Bell last week at the New York Stock ... philanthropist and social entrepreneur to care for immigrant families ... has always worked to meet the urgent healthcare needs ...
(Date:9/23/2014)... 2014 Given the nondiscretionary nature ... Fruit and Vegetable Markets industry is generally ... benefited operators over the five years to 2014. ... and demographic trends, including a focus on healthy ... capita fruit and vegetable consumption declined at an ...
(Date:9/23/2014)... 23, 2014 Antibiotics revolutionized health care in ... once killed thousands of people. But bacteria are ... antibiotic-resistant bacteria are popping up more frequently. This ... shortage of new antibiotics and discusses the prospects ... question: Why should you finish your pills if ...
(Date:9/23/2014)... The Westlake Village sedation dentist ... sedation with treatment for new patients. Studies have shown ... anxiety or dental phobia. These common conditions are more ... patients from seeking desperately needed dental care. , Patients ... surrounding areas now have an opportunity to manage their ...
(Date:9/23/2014)... The University of Maryland Medical System was ... to pay $3 million for negligence during the delivery of ... arm [shoulder dystocia occurs after the delivery of the baby’s ... pelvic bone]. , On September 5, 2014, ... Evans, et. al. v. University of Maryland Medical Systems Corporation ...
Breaking Medicine News(10 mins):Health News:NJ's Largest Nonprofit Home Health Care Agency Joins Deutsche Bank to Ring New York Stock Exchange Opening Bell 2Health News:Fruit & Vegetable Markets in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Fruit & Vegetable Markets in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 2Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 3Health News:Toddler Awarded $3 Million in a Shoulder Dystocia Case Against University of Maryland Medical System with Help from Attorneys at Gilman & Bedigian LLC 2Health News:Toddler Awarded $3 Million in a Shoulder Dystocia Case Against University of Maryland Medical System with Help from Attorneys at Gilman & Bedigian LLC 3
... military recreation managers to assist service ... members returning to active duty, ... military,personnel have been wounded by hostile and nonhostile acts in ... care, recreation,programming is playing an important role in reintegrating these ...
... history, study finds , , WEDNESDAY, Nov. 5 (HealthDay News) -- ... concern among parents when it comes to assessing their children,s ... by researchers at the University of Michigan C.S. Mott Children,s ... too much clout to a genetic test result. , "We ...
... team up to talk sex secrets, one night stands and ... Staying Alive,Foundation and SpinVox have teamed up with Lapeno, Mervin ... promote sexual health amongst,young people., The Telling It Like ... to speak openly about sex, sexual health and,HIV/AIDS. Young people ...
... Institute touts Grekos, breakthrough in Biomedical,Technology, WASHINGTON, ... http://www.RepairStemCells.org ) today announced that its Science ... present Emerging Frontiers in,Regenerative Stem Cell Therapy: Current ... Treatment of Various End Stage Diseases, at the,2008 ...
... Dynamics Research,Corporation (Nasdaq: DRCO ), ... technology and information technology services and,solutions to ... it,received an $11.4 million task order under ... indefinite delivery and indefinite,quantity (ID/IQ) contract, to ...
... Ingenious Med (IM), the leader in,inpatient practice ... groups and meet the increasing demand for a ... wide. Specialists are,quickly becoming an ever-growing segment of ... that Arizona based Cardiovascular Associates of Mesa,(CAM) joins ...
Cached Medicine News:Health News:Penn State Program To Help Wounded Warriors 2Health News:Most Parents Don't Overreact to Child Gene Tests 2Health News:Stars to 'Tell It Like It Is' at MTV's European Music Awards 2Health News:Stars to 'Tell It Like It Is' at MTV's European Music Awards 3Health News:Zannos Grekos, MD to Present Clinical Results of Regenerative Stem Cell Treatments to the Dubai Congress on Anti-Aging and Aesthetic Medicine 2Health News:Zannos Grekos, MD to Present Clinical Results of Regenerative Stem Cell Treatments to the Dubai Congress on Anti-Aging and Aesthetic Medicine 3Health News:Dynamics Research Corporation Awarded $11.4 Million Medical Healthcare Program Management Contract 2Health News:Dynamics Research Corporation Awarded $11.4 Million Medical Healthcare Program Management Contract 3Health News:Ingenious Med Adds Specialists to Clientele, Cardiovascular Group 2
Ribbon malleable, general purpose retractor....
The Wire Cutters are designed to cut Kirschner wires up to 2.5 mm diameter easily and smoothly. They are particularly useful for external fixation applications. The Wire Cutters shear fixation wires ...
The osteotome shafts are manufactured with stainless steel and are available both straight and curved in 1/4" and 1/2" sizes....
... Pulse CDC Compact Cardiac Digital Camera is a ... open, patient-friendly gantry, and provides full sized fields ... into your clinic you need a flexible system ... Find out how the Pulse reduces the ...
Medicine Products: