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Insmed Announces Promising Results From IPLEX Phase II Myotonic,Muscular Dystrophy Clinical Study

igned based on the preliminary results of this study.

About Myotonic Muscular Dystrophy

Myotonic muscular dystrophy, also known as myotonic dystrophy, dystrophia myotonica or Steinert's disease, is the most common type of adult muscular dystrophy, affecting 1 in 8000 individuals (approximately 40,000 people in the United States). Myotonic dystrophy patients develop progressive muscle wasting and weakness in the hands, forearms, legs, neck and face, as well as cataracts and cardiac arrhythmias, and eventually can become totally disabled, dying usually from respiratory or cardiac failure. At present, there is no treatment to reverse most of these symptoms. For more information about myotonic muscular dystrophy, please visit www.mda.org.

About IPLEX(TM)

IPLEX was approved in the United States in December 2005 for the treatment of children with growth failure due to severe primary IGF-I deficiency (Primary IGFD). IPLEX (rhIGF-I/rhIGFBP-3), a complex of recombinant human insulin-like growth factor-I (rhIGF-I) and its predominant binding protein IGFBP-3 (rhIGFBP-3). The drug is also being investigated for various other indications with unmet medical needs, including HIV-associated adipose redistribution syndrome, retinopathy of prematurity and amyotrophic lateral sclerosis (otherwise known as ALS or Lou Gehrig's disease).

About Insmed

Insmed is a biopharmaceutical company focused on the development and commercialization of drugs for the treatment of metabolic diseases with unmet medical needs. For more information, please visit www.insmed.com.

About the University of Rochester School of Medicine and Dentistry

The University of Rochester School of Medicine and Dentistry is a leading medical university that consistently defines health care worldwide by conducting advanced biomedical research and providing leading life science education and complex patient care. It has been designated by the National Institutes of Healt
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