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Inovio Biomedical's DNA Delivery Technology Significantly Enhances,Potency of HIV DNA Vaccine

SAN DIEGO--(BUSINESS WIRE)--Mar 26, 2007 - Inovio Biomedical Corp. (AMEX:INO), which is focused on the development of DNA vaccines and a novel solid tumor ablation therapy, announced today that the Journal of Virology has published a scientific paper prepared by Inovio's development partner, Wyeth, regarding results from a non-human primate study of an investigational DNA vaccine against HIV delivered using Inovio Biomedical's electroporation technology. The paper, titled "Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques," summarized results of a research project lead by Michael A. Egan, Ph.D., a principle research scientist at Wyeth Vaccine Research. The scientific paper concluded: "These results indicate that in vivo electroporation appears safe and can dramatically improve the delivery and immunogenicity of a multi-vector, multi-antigen pDNA vaccine in non-human primates. Collectively, these data have important implications for the design and development of an efficacious therapeutic vaccine for the treatment of HIV-1 infection."

Key observations of the study included:

-- Vaccination in combination with in vivo electroporation led to a more rapid onset and enhanced vaccine-specific immune responses.

-- This increase in CMI (cell-mediated immune) responses translates to an apparent 50-200-fold (8 weeks and 22 weeks, respectively) increase in pDNA (plasmid DNA) vaccine potency.

-- Importantly, in vivo electroporation enhanced the immune response against the less immunogenic antigens, resulting in a more balanced immune response.

-- In addition, in vivo electroporation resulted in an approximate 2.5 log10 increase in antibody responses.

"Wyeth's non-human primate data demonstrated a significant increase in both the breadth and magnitude of the cellular immune response to selected HIV antigens
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