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Inovio Biomedical's DNA Delivery Technology Shows Safety and,Enhances Gene Expression & Tumor Responses in Interim Melanoma,Clinical Study Results

SAN DIEGO--(BUSINESS WIRE)--May 24, 2007 - Inovio Biomedical Corporation (AMEX:INO), focused on the development of DNA-based DNA vaccines for cancers and infectious diseases and a novel alternative to surgery to treat localized cancers, announced today that interim clinical trial results demonstrated that a DNA-based immunotherapy delivered by Inovio's electroporation technology was safe and tolerable, facilitated gene expression, and resulted in significant objective tumor responses in treating melanoma. Inovio's electroporation-mediated DNA delivery system is designed to enhance the potency of DNA-based immunotherapies against cancers and infectious diseases.

This investigator-sponsored Phase I clinical trial, underway at the Moffitt Cancer Center in Tampa, Florida, was designed to test safety and tolerability of direct intratumoral delivery of plasmid-based IL-12 using Inovio's electroporation technology. Interim results from 24 subjects are being presented at the Third International Conference on DNA Vaccines in Malaga, Spain, by Dr. Richard Heller of the University of South Florida and Moffitt Cancer Center.

Results from the study demonstrated significant and dose-dependant increases in IL-12 protein expression in the tumors of subjects administered plasmid-based IL-12 with electroporation. These data confirm gene expression in the treated subjects. In addition, initial evaluation determined that nearly 70 percent of the 78 treated tumors (two to four melanoma tumors per subject) showed an objective local clinical response to the treatment when biopsied after initiation of the therapy.

Dr. Avtar Dhillon, Inovio's CEO, said, "This pioneering clinical study is providing compelling evidence of safety and tolerability as well as proof of principle for DNA delivery and expression using electroporation to deliver DNA into human subjects - without need of a viral or lipid vector. We look forward to
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