Navigation Links
Inovio Biomedical's DNA Delivery Technology Shows Safety and,Enhances Gene Expression & Tumor Responses in Interim Melanoma,Clinical Study Results

SAN DIEGO--(BUSINESS WIRE)--May 24, 2007 - Inovio Biomedical Corporation (AMEX:INO), focused on the development of DNA-based DNA vaccines for cancers and infectious diseases and a novel alternative to surgery to treat localized cancers, announced today that interim clinical trial results demonstrated that a DNA-based immunotherapy delivered by Inovio's electroporation technology was safe and tolerable, facilitated gene expression, and resulted in significant objective tumor responses in treating melanoma. Inovio's electroporation-mediated DNA delivery system is designed to enhance the potency of DNA-based immunotherapies against cancers and infectious diseases.

This investigator-sponsored Phase I clinical trial, underway at the Moffitt Cancer Center in Tampa, Florida, was designed to test safety and tolerability of direct intratumoral delivery of plasmid-based IL-12 using Inovio's electroporation technology. Interim results from 24 subjects are being presented at the Third International Conference on DNA Vaccines in Malaga, Spain, by Dr. Richard Heller of the University of South Florida and Moffitt Cancer Center.

Results from the study demonstrated significant and dose-dependant increases in IL-12 protein expression in the tumors of subjects administered plasmid-based IL-12 with electroporation. These data confirm gene expression in the treated subjects. In addition, initial evaluation determined that nearly 70 percent of the 78 treated tumors (two to four melanoma tumors per subject) showed an objective local clinical response to the treatment when biopsied after initiation of the therapy.

Dr. Avtar Dhillon, Inovio's CEO, said, "This pioneering clinical study is providing compelling evidence of safety and tolerability as well as proof of principle for DNA delivery and expression using electroporation to deliver DNA into human subjects - without need of a viral or lipid vector. We look forward to
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Vical Interim Clinical Results Demonstrate Safety and Tolerability of Inovio Biomedicals Electroporation DNA Delivery Technology
2. Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with Electroporation DNA Delivery Technology and New Devices at Gene Therapy Meeting
3. Inovio: DNA delivery technology shows positive human results
4. Inovio Biomedicals Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials
5. Inovio Biomedicals DNA Delivery Technology Significantly Enhances Potency of HIV DNA Vaccine
6. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
7. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
8. Phosphagenics Announces Positive Proof of Concept Results from Studies Utilizing Companys Dermal Drug Delivery Technology
9. Next Safety, Inc.s Innovative Drug Delivery System Will Replace Cigarettes and Significantly Advance Pulmonary Medication Delivery
10. PARI Pharma Presents Study Results of Sinus Delivery and Inhaled Liposomal Ciclosporin A at European Cystic Fibrosis Conference
11. News from the Battlefield of Metastatic Cancer: Epeius Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G) from the Stone of Chemistry and Physics
Post Your Comments:
(Date:7/11/2014)... Fla. , July 11, 2014  Rock Creek ... biotechnology company, today announced that the Food and Drug ... will provide comments on RCP,s Investigational New Drug ("IND") ... clinical trial in the US. Dr. ... agency,s review and comments on our IND. When we ...
(Date:7/11/2014)... Australia , July 11, 2014  Australian drug ... announced that it has raised A$19.3 million via a ... Europe , the U.S., Asia ... A$3 million from a share purchase plan (SPP) to ... million will be made in two tranches. ...
(Date:7/11/2014)... Show organisers report ... Expo 2014 were a brand new audience ... London , plus a 10% increase ...      (Logo: http://photos.prnewswire.com/prnh/20130723/629764-a) ...      (Photo: http://photos.prnewswire.com/prnh/20140711/696892-b ) ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
(Date:7/14/2014)... (PRWEB) July 14, 2014 Top nutritional ... expansion of its Quality Control and Assurance Department. As ... hired two additional, highly-qualified quality assurance (QA) and quality ... standards for which IQ Formulations has become known. ... technicians bring decades of stellar experience and qualifications to ...
(Date:7/14/2014)... BCC Research ( http://www.bccresearch.com ) ... GLOBAL MARKETS , the global synthetic biology market ... in 2018, with a five-year compound annual growth ... the fastest growing segment, with anticipated $9.7 billion ... in the pharmaceutical/diagnostics, chemical, energy, and agricultural industries ...
(Date:7/14/2014)... 13, 2014 (HealthDay News) -- Along with improving vision, ... Alzheimer,s disease and other types of dementia, a new ... of life, the researchers said. "These preliminary results ... benefits for people with dementia and their loved ones, ... Case Western Reserve University and University Hospitals Case Medical ...
(Date:7/14/2014)... 2014 (HealthDay News) -- Stress can slow a woman,s metabolism ... study included 58 women, average age 53, who were asked ... a meal than included 930 calories and 60 grams of ... took the women to burn off those calories and fat. ... events during the previous 24 hours burned 104 fewer calories ...
(Date:7/14/2014)... Skin M.D. by The ... Monday, July 14th, located at 45 East Putnam ... all week through Saturday, July 19th, with free ... to attend. The business is owned by Karen ... weight loss services, and sells high-end industry leading ...
Breaking Medicine News(10 mins):Health News:Leading Health Supplement Company IQ Formulations Expands Quality Control and Assurance Department 2Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 2Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 3Health News:Cataract Surgery a Plus for Someone With Dementia, Study Says 2Health News:Stress May Leave You Heading to the Cookie Jar 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3
... ... News reports that detainees being held by US forces at an undisclosed second detention ... temperature manipulation, and sleep deprivation. , ... Cambridge, MA (Vocus) -- Physicians for Human Rights (PHR) today called ...
... protective, experts say, , TUESDAY, May 11 (HealthDay News) -- ... offer the same protection against falls and fractures in older ... has found. , What,s more, the research suggests that when ... it actually increases the risk of falls by 15 percent ...
... As the United States moves toward the goal of a ... the Regenstrief Institute provides a framework for evaluating the costs, ... the health internet. The study, which appears in ... Medical Informatics Association , also reports on the initial assessment ...
... ... than serially, to deliver highly responsive, customer-oriented presentations. , ... London, UK (PRWEB) May 11, ... now available for Microsoft® Office PowerPoint®. This new software enables PowerPoint authors ...
... African Americans, colorectal cancer is the third most common cause ... a 90 percent cure rate, yet screening rates are much ... researchers have tried to figure out why, but most have ... haven,t explored the differences in what keeps African American men ...
... ... Take Championship Title , ... -- Human Touch ®, the U.S. market leader of innovative massage chairs, Perfect Chair® ... Pro Tim Clark for his first PGA TOUR victory in his career at one ...
Cached Medicine News:Health News:President Obama Must Investigate Reports of Detainee Abuse at Bagram Air Base 2Health News:Once-A-Year Vitamin D Megadose Ups Fracture Risk: Study 2Health News:Once-A-Year Vitamin D Megadose Ups Fracture Risk: Study 3Health News:Measuring success: Regenstrief helps assess value of investment in health info tech 2Health News:GMARK Launches World's First Web-Like, PowerPoint Navigation Software 2Health News:Exploring gender differences in colorectal cancer screenings 2Health News:Human Touch Brand Ambassador and PGA Pro Tim Clark Wins First PGA TOUR Victory at PLAYERS Championship 2Health News:Human Touch Brand Ambassador and PGA Pro Tim Clark Wins First PGA TOUR Victory at PLAYERS Championship 3
PhenoPath Laboratories provides screening, diagnostic, and prognostic testing services to hospitals, physician offices, surgery centers, biopharmaceutical companies and research institutions nationwi...
the LabOne Healthcare Group markets laboratory testing to physicians, patients, managed care companies, self-insured employers, wellness companies and hospitals....
... hemostatic gauze for a variety of inpatient and ... is easy to handle and can be customized ... that are often a challenge faced by obstetricians ... to control bleeding in outpatient procedures such as ...
Sharp tipped straight scissors. For cutting in the iris plane or cutting peripheral membranes. May also be useful in ROP cases....
Medicine Products: