Navigation Links
Inovio: DNA delivery technology shows positive human results

assessing safety, tolerability, and cellular (T-cell) and humoral (antibody) immune responses to a novel plasmid-based cancer vaccine delivered using Inovio’s proprietary DNA delivery technology. In each of the two arms of this study, i.e. with and without electroporation-enhanced delivery, three patient groups are being treated using escalating dosage levels. A total of 24 patients have been treated out of a total objective of 30 patients.

An analysis of interim data from the first and partially from the second dose treatment groups demonstrated the following points:

1. Electroporation appears safe and it is well tolerated.

2. The number of patients with significant antibody responses was four of 10 in the patient groups treated without electroporation compared to nine of 10 in the patient groups treated with electroporation.

3. The magnitude of the antibody response was significantly higher in patients treated using electroporation. Data on the T-cell response is being compiled.

The investigators continue to enroll and treat patients in the higher-dosage treatment groups.

“These data demonstrate for the first time in a clinical trial that the significant enhancement in potency of a gene- based vaccine delivered by electroporation in animals can also be seen in humans,” said Dr. Christian Ottensmeier, clinical investigator of the study.

“Achieving validation that the compelling pre-clinical data generated by Inovio and partners in large animal models can be achieved in humans is a key milestone for Inovio,” stated Avtar Dhillon, MD, Inovio’s CEO. “These results suggest that Inovio’s electroporation DNA delivery technology may provide an important alternative to viral and other DNA delivery technologies and could play a profound role in safely augmenting the immune response generated by future prophylactic and therapeutic immunot
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
2. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
3. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
4. Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
5. Prana Biotechnology Presents New Key Findings on PBT2
6. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ASCO Annual Meeting
7. Generex Biotechnology Vaccine Strategy Presented at International Conference in London
8. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at AUA Annual Meeting
9. Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session
10. Santaris Pharma presents positive preclinical data on SPC2996 at the American Association for Cancer Research
11. Antisoma plc (UK) - Second lung cancer trial adds to positive data on AS1404
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Inovio DNA delivery technology shows positive human results
(Date:5/22/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3rthk2/latest ) ... Regulations on Pharmaceutical International Multi-Center Clinical Trials in ... This is first time in history, Chinese pharmaceutical ... clinical trials of drugs in China ... on March 1, 2015. The guidance provides an ...
(Date:5/22/2015)... , May 22, 2015  China Nepstar Chain Drugstore ... leading retail drugstore chain in China ... today announced the resignation of Mr. Fuxiang Zhang ... reasons, effective immediately. Ms. Rebecca Yingnan Zhang ... Company,s board of directors, effective immediately. Meanwhile, Ms. Zhang ...
(Date:5/21/2015)... May 21, 2015 ... announced the addition of the "Arthroscopy ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose ... size the world market for Arthroscopy Devices. ... trends impacting the market for these products. ...
Breaking Medicine Technology:2015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
(Date:5/22/2015)... 22, 2015 Omar Ahmad Barrada, a ... participate in the 2015 Congress of Future Medical Leaders ... a gathering of “America’s highest achieving high school students.” ... healthcare, set new goals and learn better study habits,” ... surgery, during which we can ask the surgeons questions.” ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 “It’s ... MS/CCC, SLP, RAC-CT, CHHRP-QT, Vice President of Clinical ... very important ‘language’ that impacts how care is ... leader in long term care reimbursement, operations and ... programs and talent management, launches a new series ...
(Date:5/22/2015)... 2015 Coordinating care for people ... Historically providers have not been reimbursed or rewarded ... 2015, Medicare has paved the way by offering ... the launch of Oculus Health , an ... using the platform will now be able to ...
(Date:5/22/2015)... Power Systems is proud to announce the sponsorship of ... is in his second year of racing in the professional ... Fire Department in Missoula, MT. He entered the triathlon scene ... career, he has had 15 1st Place finishes. In his ... in all seven of his 2014 races, including two 2nd ...
(Date:5/22/2015)... May 22, 2015 According to Berks ... for drug related death, totaling almost 2,500 confirmed drug deaths, ... by state officials, totals 2,489 deaths stemming from legal and ... Pennsylvania loses seven people every day to fatal overdoses or ... singled out as one of the most rife with drug ...
Breaking Medicine News(10 mins):Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2
... patient data ... from hospital EMR to web-based PHR, MALVERN, Pa., and ... in eHealth technology,solutions and Memorial Hospital of Rhode Island (MHRI) ... an initiative led by,Dr. Charles Eaton, Director of the Center ...
... ... Mangos., MALVERN, Pa., May 8 Mangos, a ... Annual Healthcare Advertising,Award competition, sponsored by the Healthcare Market ... http://www.newscom.com/cgi-bin/prnh/20080306/AQTH073LOGO ), Selected from a field of over ...
... Reconstruction Surgery, TORONTO, May 8 /PRNewswire-FirstCall/ - ... imaging and image guidance systems for,use in the ... Duke,University Hospital in Durham, North Carolina are routinely ... procedures. Since,beginning to use SPY near the end ...
... - Depressed people may have far fewer of the receptors ... non-depressed people, new University of Michigan Depression Center research shows. ... these receptors can vary greatly. Whats more, the number of ... the severity of their symptoms - and the chances that ...
... Corporation,(Nasdaq: BPUR ) announced today that the ... of approximately $3.4 million for the,development of Hemopure(R) ... of Defense for a project entitled: A Multifunctional,Blood ... Brain Injury and Concomitant Hemorrhagic Shock., Biopure ...
... Genomic Health,Inc. (Nasdaq: GHDX ) today announced that ... will present at the Bank of,America 2008 Healthcare Conference ... 3:20 p.m. Pacific Time., In addition, Kim Popovits, ... the 7th Annual JMP Securities Research Conference,in San Francisco, ...
Cached Medicine News:Health News:InterComponentWare Inc. and Memorial Hospital of Rhode Island Celebrate Milestone 2Health News:InterComponentWare Inc. and Memorial Hospital of Rhode Island Celebrate Milestone 3Health News:InterComponentWare Inc. and Memorial Hospital of Rhode Island Celebrate Milestone 4Health News:Mangos Captures 11 HMR Awards 2Health News:Leading Plastic Surgeons at Duke Adopt SPY 2Health News:Leading Plastic Surgeons at Duke Adopt SPY 3Health News:Leading Plastic Surgeons at Duke Adopt SPY 4Health News:Depression diversity: Brain studies reveal big differences among individuals 2Health News:Depression diversity: Brain studies reveal big differences among individuals 3Health News:U.S. Navy Receives Funding for Further Development of Hemopure(R) 2Health News:U.S. Navy Receives Funding for Further Development of Hemopure(R) 3Health News:Genomic Health to Present at Bank of America 2008 Healthcare Conference and 7th Annual JMP Securities Research Conference 2
Complete calibration kits are available for both pH and manometry systems....
... Correctly formulated buffers are ... FLEXILOG pH antimony catheters. All ... calibration of internal or external ... ,Buffers are available in ...
... formulated buffers are available from ... antimony catheters. All buffers are ... internal or external reference, single ... are available in 250ml bottle ...
Flexilog custom medical carts are configured to suite the requirements of FLEXILOG motility system users. With locking wheels and storage drawers, our carts are suitable for any care provider in any ...
Medicine Products: