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Inovio: DNA delivery technology shows positive human results

Inovio Biomedical’s DNA Delivery Technology Significantly Enhances Potency of Gene-Based Prostate Cancer Vaccine

Key Milestone for First-in-Man DNA Vaccine Clinical Trial Using Inovio’s Electroporation DNA Delivery Technology


SAN DIEGO, May 22, 2007 -- Inovio Biomedical Corp. (AMEX: INO), focused on the development of DNA-based vaccines for cancers and infectious diseases and a novel alternative to surgery to treat localized cancers, announced today that interim data from a clinical study of an experimental DNA-based prostate cancer vaccine demonstrated that Inovio’s DNA delivery technology significantly enhanced the potency of the gene-based vaccine.

Dr. Christian H. Ottensmeier, MD, PhD, Cancer Research UK Senior Clinical Research Fellow at the University of Southampton, will present interim data at the 3rd International Conference on DNA Vaccines in Malaga, Spain, from this University of Southampton Phase I/II clinical study of a prostate cancer vaccine, a proprietary product owned by a third party, delivered by Inovio’s electroporation technology. The results demonstrated safety, tolerability and significantly higher antibody responses for patients who received the vaccine with Inovio’s delivery system versus those who were treated without it. Inovio’s electroporation-mediated DNA delivery system is designed to enhance the potency of DNA-based immunotherapies against cancers and infectious diseases.

Inovio Biomedical has been collaborating with Dr. Ottensmeier since 2005 on this University of Southampton clinical study, titled “A Phase I-II Trial of a DNA Vaccine with a PSMA27/pDOM Fusion Gene Given by Intramuscular Injection in HLA2+ Patients with Prostate Carcinomas with or without Electroporation.” This study of patients with recurrent prostate cancer, approved by the United Kingdom Medicines and Healthcare Products Regulatory Agency, is
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