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Innovive Pharmaceuticals Announces Additional Data Presentations at,American Association for Cancer Research Annual Meeting

NEW YORK--(BUSINESS WIRE)--Apr 12, 2007 - INNOVIVE Pharmaceuticals, Inc. (OTCBB:IVPH) today announced that data from preclinical studies of INNO-406, a potent oral dual Bcr-Abl and Lyn-kinase inhibitor for Gleevec-resistant or treatment-intolerant chronic myelogenous leukemia, will be presented at the American Association for Cancer Research Annual Meeting. The meeting takes place April 14-18, 2007 at the Los Angeles Convention Center in Los Angeles, California.

Information related to the presentations is as follows: -0-

Presentation Title:    "The dual ABL/SRC inhibitors dasatinib,

                       SKI-606, and INNO-406 are potent inhibitors of

                       T cell acute lymphoblastic leukemia cell lines

                       expressing the NUP214-ABL1 fusion kinase"

Abstract Number:       1825

Session:               Poster Section 7, Clinical Research 8, Poster

                       Board #11

Session Date and Time: Monday, April 16, 2007, 8:00 a.m. - 12:00 p.m.

Location:              Exhibit Hall, Los Angeles Convention Center

Presentation Title:    "Cell death and autophagy induced by INNO-406,

                       a novel Bcr-Abl inhibitor, in Philadelphia


Abstract Number:       2768

Session:               Poster Section 10, Cellular and Molecular

                       Biology 31, Poster Board #17

Session Date and Time: Monday, April 16, 2007, 1:00 p.m. - 5:00 p.m.

Location:              Exhibit Hall, Los Angeles Convention Center

Presentation Title:    "Overcoming imatinib resistance using Src

                       inhibitor CGP76030, Abl inhibitor nilotinib,

                       and Abl/Lyn inhibitor INNO-406 in newly

                       established K562 variants with bcr-abl gene


Abstract Number:       3246

Session:               Poster Section 29, Experimental and Molecular

  Therapeutics 26, Poster Board #8

Session Date and Time: Monday, April 16, 2007, 1:00 p.m. - 5:00 p.m.

Location:              Exhibit Hall, Los Angeles Convention Center

About INNO-406

INNO-406 (formerly known as NS-187) is an orally bioavailable, rationally designed, dual Bcr-Abl and Lyn-kinase inhibitor currently in Phase I clinical studies. According to a study published in the journal Blood (Dec. 1, 2005), INNO-406 is 25 to 55 times more potent than imatinib in vitro, and at least 10 times as effective as imatinib mesylate in suppressing the growth of Bcr-Abl bearing tumors. INNO-406 has demonstrated activity in 12 of 13 imatinib-resistant cell lines. In addition to its Bcr-Abl inhibitory properties, INNO-406 inhibits Lyn kinase. Upregulation of Lyn kinase activity is a well recognized cause of imatinib resistance. Lyn kinase activation has also been documented in a variety of solid tumors, including prostate cancer.

About INNOVIVE Pharmaceuticals

INNOVIVE Pharmaceuticals, Inc. acquires, develops and commercializes novel therapeutics addressing significant unmet medical needs in the fields of oncology and hematology. The company has four drug programs in clinical development: INNO-406, Tamibarotene, INNO-206, and INNO-305, for the treatment of chronic myelogenous leukemia, acute promyelocytic leukemia, small cell lung cancer, and acute myelogenous leukemia, respectively. For additional information visit


INNOVIVE Pharmaceuticals
Steve Kelly
President and CEO
Porter Novelli Life Sciences
Rachel Lipsitz
Media & Investor Relations


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