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Innovative Cancer Drug MabThera Again Shown To Improve Survival,Rates In Patients With Lymphoma

About the study

The open-label, randomised study was conducted in 34 centres throughout Germany and involved previously untreated stage II-IV, histologically confirmed, CD20_positive indolent NHL (FL, lymphoplasmocytic lymphoma) and mantle cell lymphoma. Patients were randomised at trial entry to treatment with MCP or a combination of rituximab and MCP (R_MCP). The primary endpoint in this study was the remission rate, defined as the rate of complete (CR) and partial (PR) remissions after induction therapy.

About MabThera

MabThera is a therapeutic antibody that binds to a particular protein - the CD20 antigen - on the surface of normal and malignant B-cells. It then recruits the body's natural defences to attack and kill the marked B-cells. Stem cells (B-cell progenitors) in bone marrow lack the CD20 antigen, allowing healthy B-cells to regenerate after treatment and return to normal levels within several months.

MabThera is indicated for the treatment of indolent and aggressive Non-Hodgkin_s Lymphoma. MabThera is known as Rituxan in the United States, Japan and Canada. To date, patients have received more than 1 million treatments with MabThera worldwide.

Genentech and Biogen Idec co-market MabThera in the United States, and Roche markets MabThera in the rest of the world, except Japan, where MabThera is co-marketed by Chugai and Zenyaku Kogyo Co. Ltd.

About Roche

Headquartered in Basel, Switzerland, Roche is one of the world_s leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world_s biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people_s health and quality of life. Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, a market leader in virology and active in other major th
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