Navigation Links
Innovative Cancer Drug MabThera Again Shown To Improve Survival,Rates In Patients With Lymphoma

Adding MabThera to first line chemotherapy significantly increases patients_ overall survival

BASEL, Switzerland (21 May, 2007) _ In a study published yesterday in the Journal of Clinical Oncology, MabThera (rituximab) plus chemotherapy (MCP*) was shown to significantly improve survival in patients with follicular lymphoma (FL) compared to chemotherapy alone.1 Follicular lymphoma is the most common type of indolent lymphoma, a slow progressing but incurable form of lymphoma.

The study demonstrated that the chances of surviving from this cancer are improved by the addition of 8 cycles of MabThera to chemotherapy - overall survival at 4 years for patients treated with MabThera plus chemotherapy was 87%, compared to only 74% for patients receiving chemotherapy alone. Additionally, patients receiving MabThera combined with chemotherapy remained in remission significantly longer than those receiving chemotherapy alone (median progression free survival has not been reached in MabThera patients vs. 29 months in patients who received chemotherapy alone). These results further strengthens the position of MabThera as the cornerstone of first-line treatment of indolent NHL, regardless of the chemotherapy used.

_The data presented in this study clearly demonstrate a significant survival benefit to patients from adding MabThera to first line treatment in indolent NHL,_ commented Prof. Michael Herold, lead investigator for the trial. _We are encouraged by the results and believe that MabThera should be added to the treatment regimen, irrespective of the type of chemotherapy used._

Non-Hodgkin_s lymphoma affects 1 million people worldwide. About 45% of NHL patients have the indolent form of the disease, which while slow to progress, has no cure. NHL is one of the fastest growing cancers and has grown in incidence by 80% since the early 1970s.

*mitoxantrone, chlorambucil and prednisolone

About the study

The open-label, randomised study was conducted in 34 centres throughout Germany and involved previously untreated stage II-IV, histologically confirmed, CD20_positive indolent NHL (FL, lymphoplasmocytic lymphoma) and mantle cell lymphoma. Patients were randomised at trial entry to treatment with MCP or a combination of rituximab and MCP (R_MCP). The primary endpoint in this study was the remission rate, defined as the rate of complete (CR) and partial (PR) remissions after induction therapy.

About MabThera

MabThera is a therapeutic antibody that binds to a particular protein - the CD20 antigen - on the surface of normal and malignant B-cells. It then recruits the body's natural defences to attack and kill the marked B-cells. Stem cells (B-cell progenitors) in bone marrow lack the CD20 antigen, allowing healthy B-cells to regenerate after treatment and return to normal levels within several months.

MabThera is indicated for the treatment of indolent and aggressive Non-Hodgkin_s Lymphoma. MabThera is known as Rituxan in the United States, Japan and Canada. To date, patients have received more than 1 million treatments with MabThera worldwide.

Genentech and Biogen Idec co-market MabThera in the United States, and Roche markets MabThera in the rest of the world, except Japan, where MabThera is co-marketed by Chugai and Zenyaku Kogyo Co. Ltd.

About Roche

Headquartered in Basel, Switzerland, Roche is one of the world_s leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world_s biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people_s health and quality of life. Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, a market leader in virology and active in other major th erapeutic areas such as autoimmune diseases, inflammation, metabolism and central nervous system. In 2006 sales by the Pharmaceuticals Division totalled 33.3 billion Swiss francs, and the Diagnostics Division posted sales of 8.7 billion Swiss francs. Roche employs roughly 75,000 worldwide and has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai. Additional information about the Roche Group is available on the Internet at <> .

All trademarks used or mentioned in this release are protected by law.

Note to editors:

1 Herold, et al. Hematological Malignancies _ Rituximab Added to First-Line Mitoxantrone, Chlorambucil and Prednisolone Chemotherapy Followed by Interferon Maintenance Prolongs Survival in Patients With Advanced Follicular Lymphoma. Journal of Clinical Oncology, May 20, 2007; 25 (15)

2 World Health Report 2000, World Health Organization, <>

. Accessed 14 May, 2007


Further Information: <>

- Roche in Oncology: <>

- Lymphoma: <>

- T he Lymphoma Coalition: <>

- Cancer: <>

- World Health Organization: <>



For more information, please contact: <>


Robert Purcell Amber Bradbury <>

Roche Ketchum <> <>

+41 61 688 0846 +44 20 7611 3842>


Related medicine technology :

1. Next Safety, Inc.s Innovative Drug Delivery System Will Replace Cigarettes and Significantly Advance Pulmonary Medication Delivery
2. Oculus Innovative Sciences Microcyn Technology Presented in Poster at European Wound Management Association Conference
3. DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy
4. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
5. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
6. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
7. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
10. MediGene Announces Cancer-Fighting Virus Shows Promise in Early Clinical Trial
11. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
Post Your Comments:
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... , June 24, 2016  American Respiratory Labs (ARL), a ... now able to perform sophisticated lung assessments in patients, homes, thanks ... Inc. Patients are no longer limited to having ... PRO ® , ARL patients like Jeanne R. of ... the comfort of her own home. ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
Breaking Medicine News(10 mins):