Navigation Links
Inflazyme Announces Outcome of Review of Phase 2b Asthma Study:,Potential Mitigating Factors Identified which Prevent Clear,Interpretation of Results

RICHMOND, British Columbia, March 12, 2007--Inflazyme Pharmaceuticals Ltd. (TSX: IZP). As announced on January 29, 2007, the preliminary results of the Phase 2b CAPSICS study with IPL512,602 showed no statistical or clinical difference between patients who received drug or placebo. However, the placebo response was surprisingly large and consistent across a number of the end-points, which prompted an examination by Inflazyme and its external experts to determine if anything untoward had occurred during the study.

To put the placebo response in perspective, we compared the results of our study to publications of other asthma clinical studies where Asthma Quality of Life was used as an endpoint. Our placebo response was two to three times greater than generally observed. Dr. William Busse and Dr. Mark FitzGerald, two leading clinical asthma experts who reviewed the data, agreed that "the large magnitude of the placebo response is surprising and could potentially obscure any apparent benefits of IPL512,602".

Our medical advisors have offered three possible factors contributing to the high placebo response. First, as is not uncommon, the study did not include placebo treatment during the run-in period at the start of the trial when patients were to be stabilized on their existing therapy. Observing a large placebo effect during this run-in period could have excluded those patients from the study.

Second, subjects were on a background therapy of inhaled corticosteroids and it is not possible to determine if there may have been compliance issues whereby patients were not taking their medications on a consistent basis as prescribed in the run-up to the study. A part of the placebo response might indeed be attributable to patients, once enrolled into the study, paying more attention to their symptoms and becoming more compliant with their background medications.This may have resulted in an improvem
'"/>




Page: 1 2 3

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Pipeline Review, 2015 market research report that provides ... pipeline stage using data sourced from in-house databases, ... on syringes and needles market products pipeline spread ... organizations supported with 73 tables and 5 figures ...
(Date:7/31/2015)... 2015 Quietly, sedately, Morocco,s pharmaceutical ... domestic pharmaceutical industry is strong, with a well-developed base ... international standards. One place where the quality ... Africa: Morocco has quietly become the second largest African ... . Indeed, Moroccan pharma companies have been making ...
(Date:7/31/2015)... According to a new market research report ... Dual-Energy X-ray Absorptiometry (DEXA), Skinfold Calipers, Air Displacement Plethysmography ... to 2019", published by MarketsandMarkets, the global Body Composition ... is estimated to grow to $1,425.7 Million by 2019, ... 2019. Browse 41 market data Tables ...
Breaking Medicine Technology:Syringes and Needles Market Products Pipeline Review 2015 Report 2Syringes and Needles Market Products Pipeline Review 2015 Report 3Syringes and Needles Market Products Pipeline Review 2015 Report 4Syringes and Needles Market Products Pipeline Review 2015 Report 5PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4
(Date:8/1/2015)... ... 01, 2015 , ... Calvary Hospital today announced that it is embarking on ... goal is to bring this Torah – dating from 1880 – back to kosher ... services. , Scroll No. 515, from the town of Taus-Domazlice, is on permanent ...
(Date:8/1/2015)... ... 01, 2015 , ... Brig and Lita Hart, icons of the network marketing ... Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been a ... have agreed to join their missions of purpose together to change the course of ...
(Date:8/1/2015)... ... August 01, 2015 , ... On Tuesday, July 28th, Symantec released ... thought to have been behind the attack on Anthem Inc. which resulted in one ... exploits, watering hole attacks and spear phishing campaigns. , For Joe Caruso, ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... BeverlyD, owner ... the March4thforWellBeing foundation, making hers the very first small business donation to kick off ... beautiful for over thirty years. Her legacy includes a complete line of raw, organic ...
(Date:8/1/2015)... ... ... 2015 Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery (CCAR) – ... Mountain and heading north. Since that day, Phil has hiked over 1400 miles in nine ... and family. He visited CCAR and left an inspirational message to his staff: “You ...
Breaking Medicine News(10 mins):Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:March4thforWellBeing Foundation Kickoff 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2
... suggested that, along with calcium, protein may also an ... is essential for building and maintaining healthy bones. During ... who were taking calcium citrate malate and vitamin D ... in people whose diets contained the most protein irrespective ...
... skin lesions known as Kaposi's sarcoma are densely related ... widespread among US gay men before the HIV epidemic ... the HIV when more men were implementing safe anal ... Kaposi's-linked virus remained common.// They think that transmission routes ...
... nanobots it not with us yet, a tiny, inexpensive motor ... in the near future, according to Penn State engineer.,The smallest ... State’s Materials Research Institute is about the size of a ... 4 mm long.// ,Tiny, but powerfull, the smallest motor’s ...
... treated by using state-of-the-art gene therapy techniques. ,Scientists from the ... into cells using ultrasound. ,Angina is a severe ... due to narrowed arteries. In some cases it may precede ... inflating a tiny balloon in the artery to help clear ...
... Illinois developed a non-invasive diagnostic tool that can study ... to the brain activity.This technique is based uopn near-infrared ... thatn other methods such as functional magnetic resonance imaging ... a UI professor of Physics, whenever the region of ...
... which could help blood cancer sufferers overcome the disease. The ... by kick starting the body's immune system to fight lymphoma, ... ,Using the new technique, scientists are able to remove ... the genetic material which identifies the cells as foreign. This ...
Cached Medicine News:Health News:Calcium and Protein Equals Strong Bones 2Health News:Oral Sex may carry AIDS related Cancer Virus 2Health News:Mini motor for micromedical applications 2Health News:Studying brain anatomy without surgery 2
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Malis CMC-III Generator provides both coagulation and cutting outputs....
Medicine Products: