Navigation Links
Independent Publication Confirms Growing Therapeutic Challenge of,T315I Mutation in Patients with CML, Notes ChemGenex

MELBOURNE, Australia, and MENLO PARK, California U.S.A. (May 21, 2007): ChemGenex Pharmaceuticals (ASX: CXS, NASDAQ: CXSP) notes the publication of new clinical data relevant to the development strategy for Ceflatonin® (homoharringtonine). The paper "Targeted therapy and the T315I mutation in Philadelphia-positive leukemias" by researchers Simona Soverini and colleagues at the University of Bologna, Italy (Haematologica Volume 92, pages 401-404) offers insight into the growing therapeutic challenge presented by the T315I Bcr-Abl point mutation in patients with chronic myeloid leukemia (CML). The T315I Bcr-Abl mutation is associated with the development of resistance to tyrosine kinase inhibitor drugs such as imatinib (Gleevec®).

The paper describes the clinical progress of Gleevec-resistant CML patients who were treated with dasatinib (Sprycel®).

Key points of the publication are as follows:

• The study followed 45 Philadelphia-positive CML and acute lymphoblastic leukemia (ALL) patients who had failed Gleevec, and who were migrated to dasatinib therapy.

• Eight of the 45 patients (17.7%) had primary resistance to dasatinib, and showed no response. Seven of these 8 patients harboured the T315I point mutation.

• A further 13 patients (28.8%) acquired resistance to dasatinib after a median of 7 months, and seven (15.6%) of these patients were T315I positive.

• In summary the T315I mutation was associated with resistance to dasatinib in 31% of patients, and the total number of patients who were resistant to therapy was 46.7%.

• This incidence of T315I-associated resistance is higher than has previously been reported and reflects, in the words of Soverini et al., that the T315I mutation "is likely to become the prevalent mutation in those who fail to benefi
'"/>




Page: 1 2 3

Related medicine technology :

1. Molecular Target of Bradmers Neuradiab Further Validated by Independent Findings
2. Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex
3. Study Continues to Show Patients With Myelodysplastic Syndromes Treated With Revlimid are Living Longer and Remaining Transfusion Independent
4. Independent publication supports the profile of CeNeS phase II compound, CNS 5161
5. Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies
6. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
7. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
8. Publication Confirms that EpCAM, the Target for Two of Micromets Product Candidates, Is Overexpressed on Cancer Stem Cells of Certain Cancers
9. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
10. Neurologix Announces Publication of Landmark Gene Therapy Study Demonstrating Safety and Statistically Significant Improvement in Patients With Advanced Parkinsons Disease
11. Nuvelo Announces Publication of Phase 2 rNAPc2 Study Results in Journal of American College of Cardiology
Post Your Comments:
(Date:3/3/2015)... Spain , March 3, 2015  AT&T 1 ... PHIA) today announced that  AT&T  is the connectivity provider ... GoSafe was designed to help provide peace of mind ... them the freedom to live active lives with the ... they need it. The AT&T network 2 helps ...
(Date:3/3/2015)... March 3, 2015   VWR  (NASDAQ:  VWR), ... and solutions, announced today the expansion of its ... This agreement allows VWR increased access to NEB,s ... the U.S. and Puerto Rico.  In addition, customers ... VWR,s e-business platform, sales organization, and VWRCATALYST, our ...
(Date:3/3/2015)... , March 3, 2015  The eleventh annual Tucson ... of the world,s top research scientists, academics, oncologists and ... theories and learn about new outcomes in patient treatments ... Each year Ventana Medical Systems, Inc. ... sponsors the Tucson Symposium at the Hilton El Conquistador ...
Breaking Medicine Technology:AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 3AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 4VWR Announces Expansion of Distribution Agreement with New England Biolabs 2Global scientific collaborators to explore latest pathology and oncology advancements at Tucson Symposium 2
... ClinStar, LLC , an established CRO providing clinical ... pharmaceutical and biotechnology industry, announced today that President and ... 6th Annual Clinical Research in Emerging Countries conference ... http://photos.prnewswire.com/prnh/20110719/SF36975LOGO ) The paradigm of traditional ...
... BOTHELL, Wash., July 21, 2011 Cardiac ... external defibrillators (AEDs) and diagnostic cardiac monitoring devices ... hospital information systems, announced today the new capability ... connectivity solution and the GE Healthcare Centricity® EMR ...
Cached Medicine Technology:ClinStar to Present on Conducting Clinical Trials in Russia 2Cardiac Science Expands Device Connectivity Solutions 2Cardiac Science Expands Device Connectivity Solutions 3
(Date:3/4/2015)... Georgia (PRWEB) March 04, 2015 The ... Sleep Awareness Week with World Sleep Awareness Day being ... awareness to the health and financial risks associated with ... support, the Sleep Apnea Treatment Centers of America have ... daily educational articles, they hope will virally inspire conversation ...
(Date:3/4/2015)... Durrie Vision, a Kansas ... in the region to offer two new intraocular lenses ... The implantable Tecnis® Multifocal lenses – now offered in ... a range of distances. Earlier this year the US ... two new IOLs – the Tecnis® Multifocal +2.75D and ...
(Date:3/4/2015)... March 04, 2015 Professionals with disabilities ... targeted outreach from companies, according to a new Think ... survey of 235 professionals with disabilities , respondents ... job search tools, including ones that are geared to ... Some highlights:, ,     Online job search tools ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Nurses, healthcare ... the American Cannabis Nurses Association (ACNA) to learn about ... a wide array of illnesses and conditions. The one-day ... Nursing,” is being offered on April 1 or April ... event was approved by the Ohio Nurses Association (OBN-001-91), ...
(Date:3/3/2015)... 2015 NOVAtime Technology, Inc. ( ... and Attendance / Workforce Management solutions, announced that ... SaaS Workforce Management / Time and Attendance ... , Since 2004, Innovative Services’ mission has ... the best quality of life. The company is ...
Breaking Medicine News(10 mins):Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 2Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 3Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 4Health News:Durrie Vision First in Region to Offer New Tecnis® Multifocus Lenses 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 2Health News:Job Seekers with Disabilities Seek Targeted Outreach from Employers and Online Job Search Tools, says New Think Beyond The Label Survey 3Health News:American Cannabis Nurses Association Announces Speaker Lineup for Educational Seminar in Cleveland 2Health News:American Cannabis Nurses Association Announces Speaker Lineup for Educational Seminar in Cleveland 3Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 3
... salt to reduce heart disease risk. The other side says ... people. Which is correct? There isn’t a simple answer. ... component of salt) in the diet lowers blood pressure. But ... her genes, age, and medical conditions, reports the November 2006 ...
... identified a naturally occurring enzyme that can break down ... Alzheimer's disease.// The finding may provide researchers with new ... of Alzheimer's patients and could one day help them ... of Medicine in St. Louis showed earlier this summer ...
... 2007 issue of the Pediatric Blood & Cancer investigates ... healthcare between industrialized and developing countries, as a way ... ,Pediatric oncology has witnessed path breaking strides in ... decades, but developing nations still have a long way ...
... the victims unintentionally demand, or actually have, sex while ... ,Research into this condition called sexsomania has been ... it. This disorder usually causes problems in relationships. It ... ,Several researchers believe sexsomania to be a variant of ...
... to researchers, a gene determines people’s sensitivity to pain.In ... pain could be prevented by blocking the expression of ... This could be a breakthrough in development of new ... a quarter of them had the genetic variant that ...
... of Singapore recently by researchers, reported in the American ... the tangible benefits of curries commonly used by Asian ... meals which are accompanied by a helping of curries ... is often indelibly associated with aging. Asian elders who ...
Cached Medicine News:Health News:Naturally Occurring Enzyme Can Break Down Key Part of Alzheimer's Plaques 2Health News:Videoconferencing, an impetus to Pediatric Oncology 2Health News:Gene determines pain threshold... 2Health News:Spices in curries spruce up aging minds 2
... the word "laboratory," it brings to mind images of ... familiar items. With the introduction of the Brady Code ... reader to the list of critical lab tools. Brady ... tool for the lab with the introduction of the ...
... stainless steel work surface. ... vibration to protect operator, ... vibration-producing equipment from the ... allows for multiple vibration-free ...
Round, height-adjustable, steel laboratory stools with small footprint for small spaces • Choose options like different height-adjustment mechanism or paint finish. • your choice of color...
... Chrome-plated metal frames ensure ... optimal cleanliness and chemical ... come with user-friendly pnuematic ... adjustment. Fixed footring standard. ...
Medicine Products: