Navigation Links
In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells

Pre-Clinical Results Demonstrate Potential of ONCONASE for Treatment of Neuroblastoma

BLOOMFIELD, N.J., June 27, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that new data show ONCONASE, the company's lead drug candidate, is active against naive and chemoresistant neuroblastoma cells.

The pre-clinical in vitro and in vivo data published in Cancer Letters (2007; Vol. 250, Issue 1: 107-116) through a collaboration between Alfacell and Martin Michaelis, M.D., Ph.D., at the Institute of Medicinal Virology at Johann Wolfgang University of Frankfurt, were also recently presented in Germany.

Conclusions from the studies presented indicate that ONCONASE inhibits neuroblastoma cell growth and induces caspase-independent cell death in neuroblastoma cells independently of P-gp expression or p53 status, which has been shown to contribute to multi-drug resistance in neuroblastoma as well as most other human cancers. Transmission electronic microscope investigations suggest that ONCONASE induces a process in neuroblastoma cells called autophagy (the digestion of cellular constituents by enzymes of the same cell), which leads to apoptosis (programmed cell death). Anti-tumor activity of ONCONASE against drug-sensitive and chemoresistant neuroblastoma xenografts was confirmed in animals.

"The data speak to the broad potential application for ONCONASE in various types of cancer other than the gateway indication for mesothelioma," said Kuslima Shogen, Alfacell's chairman and chief executive officer. "We now have an even better understanding of the mechanism of action that ONCONASE utilizes in overcoming multiple drug resistance in various tumor types."

Neuroblastoma is a cancer that forms in the nerve tissue. It is the most common cancer in infants, and the fourth most common type of cancer in children. Neurons (nerve cells) are the main components of the brain and spinal cord an
'"/>




Page: 1 2 3

Related medicine technology :

1. Samaritan Announces Positive Data in Nonclinical (IND) In-Vitro Studies for Promising Alzheimers Drug
2. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
3. AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
5. ANA380 Exhibits Activity In Vitro Against Multiple Clinically Relevant Hepatitis B Virus Mutants
6. Targanta Reports Improved Ability of Oritavancin to Stop Bacteria Growth In Vitro Compared With Other Glycopeptide Antibiotics
7. Preclinical Data Show Alfacells Onconase Inhibits Tumor Growth of Non-Small Cell Lung Cancer, Breast Cancer Cells
8. Researchers Identify Intracellular Pathway of Alfacells Onconase
9. In vivo Study Results Demonstrating Potential of Alfacells Onconase for Treatment of Non-Small Cell Lung Cancer Published in Anticancer Research
10. Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacells Onconase
11. Alfacells Onconase Highlighted in Latest Edition of Handbook of Therapeutic Antibodies
Post Your Comments:
(Date:8/28/2015)... , Aug. 28, 2015  Delays in ... projects can slow down the decision-making process, resulting ... therefore, absolutely critical for biopharmaceutical companies to develop ... approval process for quicker and more meaningful insights. ... Best Practices, LLC, nearly three-quarters of benchmarked study ...
(Date:8/28/2015)... PUNE, India , August 28, 2015 ... "Cancer Biomarker Market by Tumor (Breast, Lung, Prostate) Type ... Immunoassay) Application (Diagnostic, Drug Discovery, Prognostic) & Geography - ... Biomarkers Market is expected to reach around 17,689.0 Million ... the forecast period of 2015 to 2020. ...
(Date:8/28/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/686gwf/investigation ... Report on China,s Bevacizumab Market ,2010-2019" report to ... trade name of Avastin, bevacizumab injection is the first ... was approved by CFDA to treat metastatic colorectal cancer. ... all come from Roche and its subsidiary Genectech. ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Bevacizumab Market 2015-2019 2
... 5, 2011 Today, Molecular Devices, a leading ... discovery and life sciences research, announced that the ... Devices. (Logo:   http://photos.prnewswire.com/prnh/20100406/SF82092LOGO ) ... continues to grow as a leading technology supply ...
... July 5, 2011 Regulators are brandishing a ... officers they suspect of wrongdoing—in effect, using an ... It is unclear whether they intend to routinely ... "death penalty" by some—but at a recent conference ...
Cached Medicine Technology:Genetix Joins Molecular Devices: Combining Businesses to be in a Better Position to Serve Customers 2Feds Might 'Banish' More Execs for Misconduct, Attorney Says 2Feds Might 'Banish' More Execs for Misconduct, Attorney Says 3
(Date:8/31/2015)... Valley, CA (PRWEB) , ... August 31, 2015 , ... ... Ghasri, to the practice. Dr. Pedram Ghasri is a graduate of the University of ... neuroscience and continued his studies at the University of California, Irvine Medical School. As ...
(Date:8/31/2015)... , ... August 31, 2015 , ... In preparation for ... Research, maker of the BEAN™ personal sound amplifier, is offering caregivers “7 Reasons to ... as a way of coping with a variety of home healthcare challenges, specifically as ...
(Date:8/31/2015)... ... 2015 , ... For 12 years, since 2004, the Mesothelioma Applied Research ... Awareness Day . On this day, and in the weeks leading up to it, ... helping the cause. , “One of the ways a person can be involved is ...
(Date:8/31/2015)... ... ... MeYou Health ®, a social well-being company and wholly owned subsidiary of Healthways, Inc., ... step tracker. , Walkadoo is a pedometer-based walking program that provides daily ... Walkadoo member 10,000 steps a day (as is typical for many walking programs), Walkadoo ...
(Date:8/31/2015)... ... 31, 2015 , ... It’s a lot like coming home. Life-long Fox Valley ... During his first days on the job, he’s run into residents of the retirement ... like knowing that they’re living in such a wonderful place,” he said. GreenFields, which ...
Breaking Medicine News(10 mins):Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 3Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 3Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:Friendship Senior Options Welcomes New Executive Director for GreenFields of Geneva 2
... French . Montreal, July 8, 2010 - A ... Immunology and Cancer (IRIC) of the University of Montreal ... Led by IRIC Principal Investigators Martine Raymond, Alain Verreault ... the Biotechnology Research Institute of the National Research Council ...
... ... , ... July 8, 2010 -- Anakam® and Axolotl Corp. are working together to support a ... be implemented successfully within a health information exchange. Powered by Axolotl,s Elysium® Exchange, ...
... ... iPad’s touch screen interface to improve cost effective collaboration and documentation , ... Austin, TX (PRWEB) July 8, ... iPad for point of care documentation and coordination across the continuum of ...
... Va.SNM is optimistic that the anticipated recommencement of the ... (NRU) reactor in Chalk River, Canada, will provide short-term ... patients and the nuclear medicine community for more than ... this reactor will not solve the ongoing production and ...
... ... June , ... (PRWEB) -- Suite101.com, a global content site that provides trusted and reliable information to ... 2010, providing a window into consumer online reading behavior. In June, the most popular articles ...
... ... creator Nick Gregan give the viewer the opportunity to let their mind explore the ... wild. It challenges them to investigate the landscape of the physical form and view ... the spectator to look beyond the obvious and question what they see at first ...
Cached Medicine News:Health News:Vitamin B3 as a novel approach to treat fungal infections 2Health News:Anakam And Axolotl Collaborate To Deliver A Multi-Factor Authentication Platform For Santa Cruz Health Information Exchange 2Health News:Anakam And Axolotl Collaborate To Deliver A Multi-Factor Authentication Platform For Santa Cruz Health Information Exchange 3Health News:Anakam And Axolotl Collaborate To Deliver A Multi-Factor Authentication Platform For Santa Cruz Health Information Exchange 4Health News:Kinnser is First Home Health Software Provider to Utilize the iPad for Point of Care Connectivity 2Health News:SNM cautions that Canada's Chalk River coming back online will not solve long-term isotope shortage 2Health News:SNM cautions that Canada's Chalk River coming back online will not solve long-term isotope shortage 3Health News:Suite 101.com Provides Insight Into Consumer Reading Behavior Online 2Health News:Suite 101.com Provides Insight Into Consumer Reading Behavior Online 3Health News:Suite 101.com Provides Insight Into Consumer Reading Behavior Online 4Health News:Ambiguous Misdirection is an Awakening of the Imagination, Nick Gregan Challenges the Viewer to Let Their Imagination Run Wild 2
Helmer's Horizon Series line of refrigerators are designed specifically for the cost conscious buyer. This line offers outstanding performance, quality, and the features you need to ensure the safety...
... Helmer presents the i.Series ... innovative solutions for the ... sophisticated features than ever ... Refrigerators are at the ...
This storage freezer, which is based on our premium freezer line, maintain red cells safely below regulatory standards at -86C (-123F). Recorder is standard for model 8590. Model 8590 is UL Listed, C...
... requirements of blood banking and processing ... meets American Association of Blood Banks ... and U.S. Food & Drug Administration ... platelet incubators feature alarm systems that ...
Medicine Products: