Navigation Links
In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells

Pre-Clinical Results Demonstrate Potential of ONCONASE for Treatment of Neuroblastoma

BLOOMFIELD, N.J., June 27, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that new data show ONCONASE, the company's lead drug candidate, is active against naive and chemoresistant neuroblastoma cells.

The pre-clinical in vitro and in vivo data published in Cancer Letters (2007; Vol. 250, Issue 1: 107-116) through a collaboration between Alfacell and Martin Michaelis, M.D., Ph.D., at the Institute of Medicinal Virology at Johann Wolfgang University of Frankfurt, were also recently presented in Germany.

Conclusions from the studies presented indicate that ONCONASE inhibits neuroblastoma cell growth and induces caspase-independent cell death in neuroblastoma cells independently of P-gp expression or p53 status, which has been shown to contribute to multi-drug resistance in neuroblastoma as well as most other human cancers. Transmission electronic microscope investigations suggest that ONCONASE induces a process in neuroblastoma cells called autophagy (the digestion of cellular constituents by enzymes of the same cell), which leads to apoptosis (programmed cell death). Anti-tumor activity of ONCONASE against drug-sensitive and chemoresistant neuroblastoma xenografts was confirmed in animals.

"The data speak to the broad potential application for ONCONASE in various types of cancer other than the gateway indication for mesothelioma," said Kuslima Shogen, Alfacell's chairman and chief executive officer. "We now have an even better understanding of the mechanism of action that ONCONASE utilizes in overcoming multiple drug resistance in various tumor types."

Neuroblastoma is a cancer that forms in the nerve tissue. It is the most common cancer in infants, and the fourth most common type of cancer in children. Neurons (nerve cells) are the main components of the brain and spinal cord an
'"/>




Page: 1 2 3

Related medicine technology :

1. Samaritan Announces Positive Data in Nonclinical (IND) In-Vitro Studies for Promising Alzheimers Drug
2. terna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
3. AEterna Zentaris Discloses First In Vitro Data for its PI3K Inhibitors at the AACR Annual Meeting in Los Angeles
4. AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles
5. ANA380 Exhibits Activity In Vitro Against Multiple Clinically Relevant Hepatitis B Virus Mutants
6. Targanta Reports Improved Ability of Oritavancin to Stop Bacteria Growth In Vitro Compared With Other Glycopeptide Antibiotics
7. Preclinical Data Show Alfacells Onconase Inhibits Tumor Growth of Non-Small Cell Lung Cancer, Breast Cancer Cells
8. Researchers Identify Intracellular Pathway of Alfacells Onconase
9. In vivo Study Results Demonstrating Potential of Alfacells Onconase for Treatment of Non-Small Cell Lung Cancer Published in Anticancer Research
10. Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacells Onconase
11. Alfacells Onconase Highlighted in Latest Edition of Handbook of Therapeutic Antibodies
Post Your Comments:
(Date:7/23/2014)... , July 23, 2014 UBM Medica ... – a new online community and information resource for ... manage and treat their patients with neurological disorders ... with an aging population, necessitates greater access to dedicated ...  Key statistics on neurological conditions include: , ...
(Date:7/23/2014)... , July 23, 2014 Research and ... Electrocardiograph (ECG) Market by Product, End-user & by Lead ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... segmented into three major segments, namely, holter monitor, resting, ... was valued at $3,683 million in 2013 and is ...
(Date:7/23/2014)... /PRNewswire-iReach/ -- The Centers for Medicare & Medicaid Services ... Improvement Organization (QIN-QIO) contract to a partnership led by ... August 1, WVMI will launch Quality Insights Quality Innovation ... Pennsylvania , Delaware , ... Network will engage providers and the community in multiple, ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3Announcing a New Regional Approach to Medicare Quality Improvement 2
(Date:7/23/2014)... (PRWEB) July 23, 2014 The beauty ... dollars by the year 2020, according to recent news ... among the top sellers in the U.S. and the ... wrinkle cream under $100 is now reviewed at ... help a first-time or experienced shopper to compare the ...
(Date:7/23/2014)... The puffiness that can appear underneath the ... to a new guide published at the CherryNews.com website. ... U.S. is now available for men and women to ... that is now published is meant to provide reliable ... While surgical techniques are available, there are all-natural ingredients ...
(Date:7/23/2014)... scientist from the University of Exeter has developed ... diagnosing a frequently fatal lung disease which attacks ... bone marrow transplant recipients. , The lateral-flow device ... pulmonary aspergillosis, a notoriously difficult to diagnose disease ... , Invasive aspergillosis is a leading ...
(Date:7/23/2014)... HealthDay Reporter WEDNESDAY, July 23, ... not be as effective against cystic fibrosis as previously ... one of the medications might stop the other from ... and there,s still hope for the medications known as ... study,s senior author. "The development of drugs like ...
(Date:7/23/2014)... Home Care Assistance Calgary , ... is proud to announce the next installment in its ... wide range of health and wellness-related fields. The upcoming ... author Nancy Kriseman, and will cover the most common ... by becoming more self-aware. In particular, Nancy will discuss ...
Breaking Medicine News(10 mins):Health News:Best Wrinkle Cream Under $100 Reviewed at Top News Website Online 2Health News:Puffy Eyes Serum Explored in Complimentary Guide Released at Consumer News Website 2Health News:New device detects deadly lung disease 2Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 2Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 3Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3
... ... ... 2009 -- Changing global health is challenging health professionals everywhere to rethink how they ... services professionals to network and collaborate with colleagues from across the globe and see ...
... ,Trailblazers, Who Have Advanced the Fields of Civil Rights, ... NOVATO, Calif., June 3 Purple Communications(TM), Inc. (Nasdaq: ... providers of text and video relay and on-site interpreting ... acknowledges, and celebrates Deaf culture and achievement in America. ...
... physicians, but Temple has met that challenge head on ... Since 1971, nearly 700 underrepresented African American and ... School of Medicine. And this summer, the school will ... catchy acronym and the perseverance of Raul DeLa Cadena. ...
... Hall-of-Famer Mike Ditka, one of the most popular figures in ... this month,s episode of Sharing Miracles -- a ... inspirational stories of real patients. Sharing Miracles airs ... Known for his flamboyant style, "Da Coach" is one ...
... will enhance cash management efficiencies and reduce costs , ... America announced today that Boston Medical Center, the largest safety ... to transform a significant portion of the hospital,s Accounts Payable ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050720/CLW086LOGO-b ) ...
... Identifies Key Motivators for Participation , , ... Insurance Company of America (Guardian), a leading provider of ... the results of a comprehensive survey on consumers, attitudes ... (HSAs) and high-deductible health plans (HDHPs). , ...
Cached Medicine News:Health News:ESRI Health GIS Conference to Feature Speakers Innovating Health Care 2Health News:ESRI Health GIS Conference to Feature Speakers Innovating Health Care 3Health News:ESRI Health GIS Conference to Feature Speakers Innovating Health Care 4Health News:Purple Communications(TM) Launches Dream Bigger Initiative Celebrating the Stories, Culture, and Heritage of America's Deaf and Hard-of-Hearing Community 2Health News:Purple Communications(TM) Launches Dream Bigger Initiative Celebrating the Stories, Culture, and Heritage of America's Deaf and Hard-of-Hearing Community 3Health News:Purple Communications(TM) Launches Dream Bigger Initiative Celebrating the Stories, Culture, and Heritage of America's Deaf and Hard-of-Hearing Community 4Health News:Purple Communications(TM) Launches Dream Bigger Initiative Celebrating the Stories, Culture, and Heritage of America's Deaf and Hard-of-Hearing Community 5Health News:Purple Communications(TM) Launches Dream Bigger Initiative Celebrating the Stories, Culture, and Heritage of America's Deaf and Hard-of-Hearing Community 6Health News:Stepping up minority recruiting 2Health News:Stepping up minority recruiting 3Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 2Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 3Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 4Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 5Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 6Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 7Health News:'Sharing Miracles' Television Program to Feature Super Bowl Winner, Hall-of-Famer Mike Ditka 8Health News:Boston Medical Center Selects Bank of America to Assist with Payments Transformation 2Health News:Boston Medical Center Selects Bank of America to Assist with Payments Transformation 3Health News:Guardian Survey Reveals Widespread Lack of Understanding of Health Savings Accounts 2Health News:Guardian Survey Reveals Widespread Lack of Understanding of Health Savings Accounts 3Health News:Guardian Survey Reveals Widespread Lack of Understanding of Health Savings Accounts 4