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In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression

ectively, were:
  • Overall Pain 20.3 percent, 17.9 percent;
  • Headache 25.6 percent, 15.6 percent;
  • Back Pain 18.2 percent, 20.2 percent;
  • Shoulder Pain 17.9 percent, 16.2 percent;
  • Interference with Daily Activities 29.5 percent, 23.2 percent;
  • Time in Pain While Awake 28.8 percent, 26.3 percent.

Efficacy, safety, and tolerability outcomes following direct switch from SSRI to duloxetine were similar to those observed for start-taper switch. Few patients experienced a serious adverse event (5 patients during the 10 weeks of treatment and 1 during the taper period), and there was a low rate of discontinuations due to adverse events (6.6 percent DS vs. 3.8 percent STS).

This was an open-label study, so biases inherent in open-label studies could have been a factor in the observed outcomes. Due to the large number of possible SSRI/dose possibilities for patients entering the study, it was necessary for study investigators to use their clinical judgment to devise an appropriate 2-week down-titration regimen for patients in the STS group. Although general guidance was provided to investigators within the study protocol, the taper was nevertheless not rigidly standardized.

About Duloxetine
While duloxetine’s mechanism of action in humans is not fully known, it is believed to affect both serotonin and norepinephrine/noradrenaline mediated nerve signalling in the brain and the spinal cord. Based on pre-clinical studies, duloxetine is a balanced and potent reuptake inhibitor of serotonin and norepinephrine/noradrenaline. Scientists believe its effect on pain perception is due to increasing the activity of serotonin and norepinephrine in the central nervous system.

Duloxetine is approved for the treatment of depression and diabetic peripheral neuropathic pain in many countries and is approved in some countries for the treatment of stress urinary
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