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In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression

nts who are not adequately responding to SSRI therapy,” he said.

Duloxetine, a member of a class of drugs commonly referred to as serotonin and norepinephrine reuptake inhibitors (SNRI)5, is approved in more than 70 countries for the treatment of major depression.

There is a possibility of an increased risk of suicidal thoughts or behaviour in children and young adults treated with antidepressants. Patients should call their doctor right away if they experience worsening depression symptoms, unusual changes in behaviour or thoughts of suicide, especially at the beginning of treatment or after a change in dose.

Notes to Editors:

About the Study1
Methodology
Subjects were outpatients who met criteria for MDD despite having taken an SSRI antidepressant for at least 6 weeks, and who had a Hamilton Depression Rating Scale (HAMD17) total score of ?15 and a Clinical Global Impression of Severity (CGI-S) score of ?3. Eligible patients were randomized to either abrupt discontinuation of their SSRI immediately followed by initiation of duloxetine (Direct Switch) or to tapered discontinuation of their SSRI over 2 weeks and simultaneous administration of duloxetine (Start-taper Switch). Painful physical symptoms were assessed at baseline and at the 10-week study endpoint via a variety of measures including 6 Visual Analogue Scales (VAS) for pain, and the Symptom Questionnaire-Somatic Subscale (SQ-SS).

Results included:1

  • Clinically significant levels of pain (mean baseline VAS scores >30 mm) were seen across all VAS pain measures prior to switching.
  • Switch to duloxetine resulted in significant improvements on all pain measures in both treatment groups.
  • Mean improvements in each of the VAS pain scores, expressed as a percentage of baseline VAS scores for the Direct-Switch and Start-Taper-Switch groups resp
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