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In New Study, Duloxetine Reduced Non-specific Pain and Emotional,Symptoms Associated with Depression

afety and tolerability.
About Duloxetine
Duloxetine is believed to impact both serotonin and norepinephrine/noradrenaline mediated nerve signalling in the brain and the spinal cord. Based on pre-clinical studies, duloxetine is a balanced and potent reuptake inhibitor of serotonin and norepinephrine/noradrenaline. While the mechanism of action of duloxetine in humans is not fully known, scientists believe its effect on pain perception is due to increasing the activity of serotonin and noradrenaline in the central nervous system.

Duloxetine is approved for the treatment of depression and diabetic peripheral neuropathic pain in many countries and is approved in some countries for the treatment of stress urinary incontinence. Duloxetine also is approved in the United States and Mexico for the treatment of generalised anxiety disorder. Duloxetine is approved only for adults 18 and over. In children and teens, antidepressants can increase the risk of suicidal thoughts or actions. Patients should call their doctor right away if they experience worsening depression symptoms, unusual changes in behavior or thoughts of suicide, especially at the beginning of treatment or after a change in dose.

The most commonly reported adverse reactions in patients with depression treated with duloxetine in clinical trials were nausea, dry mouth, headache and diarrhea. However, the majority of common adverse reactions were mild to moderate, they usually started early in therapy and most tended to subside even as therapy was continued. The most commonly observed adverse reactions in patients with diabetic neuropathic pain treated with duloxetine were: nausea; somnolence; dizziness; and headache. The most common adverse reactions in patients with generalised anxiety disorder treated with duloxetine in clinical trials were nausea, fatigue, dry mouth, drowsiness, constipation, insomnia, decreased appetite, hyperhidrosis, decreased libido, vomiting, ejaculation delay an
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