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Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

r Research. The critical question is whether this approach would be safe and effective in smokers at high risk to develop lung cancer. Given that rapamycin is relatively inexpensive and FDA-approved for other indications, we are designing clinical trials in humans to address these questions and hope to have these answers in the near future.

Further research is needed to determine whether doses of rapamycin that achieve an anti-tumor effect in mice are similarly effective in humans, and whether giving a dose that would be sufficient for an anti-tumor effect would cause unacceptable levels of immune suppression or toxicity.

For more information on Dr. Denniss research, go to http://ccr.cancer.gov/Staff/Staff.asp?profileid=5727

For more information about cancer, please visit the NCI Web site at http://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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Reference: Granville C, Warfel N, Tsurutani J, Hollander C, Robertson M, Fox S, Veenstra T, Issaq H, Linnoila I, Dennis P. Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity and phenotypic progression of tobacco carcinogen-induced murine lung tumors. C
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