Navigation Links
Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

these proteins and the cellular pathway that they are associated with may be a realistic tactic for lung cancer chemoprevention. Because the most promising inhibitors of this pathway target mTOR as opposed to Akt, the researchers focused on an FDA-approved inhibitor of mTOR, rapamycin.

Investigators performed several experiments in mice to examine the effects of mTOR inhibition on new tumor formation and on established tumors. Mice were exposed to NNK (a carcinogen only found in tobacco) through injection into the peritoneum (the area that contains the abdominal organs). Rapamycin, which targets mTOR, was administered either one or 26 weeks after NNK administration. The group that was given rapamycin at week one was used to test the drug as a preventative agent. The group that received treatment at week 26 was used to test the effect on established tumors. A once daily dose given five out of seven days a week, which was a standard used in previous studies, was compared to an every-other-day, or ‘qod, regimen. Comparisons revealed that rapamycin levels were better maintained with an every-other-day administration.

Importantly, the levels of rapamycin achieved in mice were comparable to those in humans. On the daily regimen, which began on week 26, tumor size, the rate of tumor proliferation, and mTOR activity were reduced, but the rate at which tumor cells multiplied was unchanged. When rapamycin was administered one week after NNK, the every-other-day regimen was well tolerated and produced the best results in terms of tumor cell multiplication (90 percent reduction), cell abnormalities (changes in appearance, shape, etc.), and size (74 percent decrease). This was correlated with decreased proliferation of tumor cells and inhibition of mTOR.

Our studies provide an exciting link between exposure to an important tobacco carcinogen, NNK, and mTOR, said Phillip A. Dennis, M.D., Ph.D., head, Signal Transduction Section of NCI's Center for Cance
'"/>




Page: 1 2 3 4

Related medicine technology :

1. GenoMed Prevents Sickle Cell Pain for Over a Year
2. Progenics and Wyeth Announce Positive Results from Three-Month Clinical-Extension Study of Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness
3. Aeolus Pharmaceuticals AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation
4. Abraxis BioScience Presents Data from Pre-Clinical Study That Provide Evidence for Chemotherapy-Induced Angiogenesis and Rationale for Combining nab-Paclitaxel (Abraxane) with Anti-Angiogenic Agents to Increase Tumor Response
5. Cleveland BioLabs Protectan CBLB502 Demonstrates Strong Survival Benefits as Mitigator Against Radiation-Induced Damage in Study
6. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
7. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
8. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
9. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
Post Your Comments:
(Date:1/23/2015)... N.C. , Jan. 23, 2015 For the pharmaceutical ... in dealing with payers. Likewise, the importance of the managed ... will only continue to grow as payer formularies and provider ... therapies. At the same time, managed markets leaders ...
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) ... Market (Indwelling or Foley Catheters, Intermittent Catheters and Male ... Share, Growth, Trends and Forecast 2014 - 2020" ... present, the global market for urinary catheters is experiencing ...
(Date:1/23/2015)...  MedScope ( www.medscope.org ), the leading provider of medical ... Connected World magazine Connected World Award for its ... be used anywhere, anytime. The nomination was made by ... nominating MedScope, Landon Garner , Director of Marketing ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2
... WEST BEND, Wis., Aug. 8, 2011 Eurofins ... service provider and Spaulding Clinical Research, LLC., US-based, ... Device Manufacturer, announce a joint partnership agreement.  This ... facilitates collaboration on integrated clinical services to engage ...
... Va., Aug. 8, 2011 Science Applications International ... has completed the acquisition of Vitalize Consulting Solutions ... and information technology (IT) services for healthcare enterprises. ... the commercial hospital market that are implementing electronic ...
Cached Medicine Technology:Spaulding Clinical Announces New Joint Partnership for Global Studies with Eurofins Optimed Clinical Research 2SAIC Completes Acquisition of Vitalize Consulting Solutions, Inc. 2
(Date:1/22/2015)... West Hollywood, California (PRWEB) January 22, 2015 The ... 22, 2015 at 10 a.m., to commemorate the 42nd anniversary of ... the United States. , “It’s been 42 years since the Roe ... to choose is still as present as ever,” said City of ...
(Date:1/22/2015)... Nashville, TN (PRWEB) January 22, 2015 Gabe’s Chemo ... Chemo Duck App, the first app ever created for kids with ... all Apple phones and devices, is filled with enjoyable games to ... life and treatments. The free app helps to keep kids entertained, ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many trendy ... on Facebook, Twitter, and Pinterest. The fans will have an ... lottery every week. , Moreover, the company has extended its ... Angelweddingdress homepage for more information. , Angelweddingdress is ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... ... ... ... ...
... ... ... , ... , , , , ...
... ... ... , ... , , ...
... 2010 winners of the Young Investigator Award. This ... individuals within 5 years of receiving doctoral degrees who ... Biology 2010 meeting in Anaheim in April 2010. ... by a committee on the basis of originality and importance ...
... ... of the Center for Quality Growth and Regional Development at Georgia Institute of Technology, ... Forum: Livability and Sustainable Communities – Taking Action for a Clean Energy Future. ... Atlanta, Ga. (PRWEB) ...
... ... ... ... ...
Cached Medicine News:Health News:FDA, FSIS, CDC Collaborate on Methods to Measure Success of Food Safety Programs 2Health News:FDA, FSIS, CDC Collaborate on Methods to Measure Success of Food Safety Programs 3Health News:FDA, FSIS, CDC Collaborate on Methods to Measure Success of Food Safety Programs 4Health News:FDA, FSIS, CDC Collaborate on Methods to Measure Success of Food Safety Programs 5Health News:FDA, FSIS, CDC Collaborate on Methods to Measure Success of Food Safety Programs 6Health News:Consumer Alert: Denture Cream Maker Warns Doctors of Product Dangers 2Health News:Consumer Alert: Denture Cream Maker Warns Doctors of Product Dangers 3Health News:Consumer Alert: Denture Cream Maker Warns Doctors of Product Dangers 4Health News:89 Women Celebrate Mardi Gras with Mammograms 2Health News:89 Women Celebrate Mardi Gras with Mammograms 3Health News:SEBM Young Investigator Awards for 2010 2Health News:Dr. Catherine Ross to Participate Today in White House Clean Energy Economy Forum 2Health News:Dr. Catherine Ross to Participate Today in White House Clean Energy Economy Forum 3Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 2Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 3Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 4Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 5Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 6Health News:Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies 7
... H. pylori Rapid Test Strip and Device ... detection of antibodies to Helicobacter pylori (H. ... to aid in the diagnosis of H. ... age and older. They are intended for ...
Immunoassay for rapid, qualitative detection of IgG antibodies specific to Helicobacter pylori in whole blood....
Clearview H. pylori II uses rapid, two-step technology for the direct detection of H. pylori antibodies. , ,The patented, innovative technology used by Clearview H. pylori II provides highly sen...
... Uni-Gold™ H. pylori assay is intended ... detection of IgG antibodies to Helicobacter ... serum, plasma or whole blood as ... H. pylori infection in patients with ...
Medicine Products: