Navigation Links
Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

these proteins and the cellular pathway that they are associated with may be a realistic tactic for lung cancer chemoprevention. Because the most promising inhibitors of this pathway target mTOR as opposed to Akt, the researchers focused on an FDA-approved inhibitor of mTOR, rapamycin.

Investigators performed several experiments in mice to examine the effects of mTOR inhibition on new tumor formation and on established tumors. Mice were exposed to NNK (a carcinogen only found in tobacco) through injection into the peritoneum (the area that contains the abdominal organs). Rapamycin, which targets mTOR, was administered either one or 26 weeks after NNK administration. The group that was given rapamycin at week one was used to test the drug as a preventative agent. The group that received treatment at week 26 was used to test the effect on established tumors. A once daily dose given five out of seven days a week, which was a standard used in previous studies, was compared to an every-other-day, or ‘qod, regimen. Comparisons revealed that rapamycin levels were better maintained with an every-other-day administration.

Importantly, the levels of rapamycin achieved in mice were comparable to those in humans. On the daily regimen, which began on week 26, tumor size, the rate of tumor proliferation, and mTOR activity were reduced, but the rate at which tumor cells multiplied was unchanged. When rapamycin was administered one week after NNK, the every-other-day regimen was well tolerated and produced the best results in terms of tumor cell multiplication (90 percent reduction), cell abnormalities (changes in appearance, shape, etc.), and size (74 percent decrease). This was correlated with decreased proliferation of tumor cells and inhibition of mTOR.

Our studies provide an exciting link between exposure to an important tobacco carcinogen, NNK, and mTOR, said Phillip A. Dennis, M.D., Ph.D., head, Signal Transduction Section of NCI's Center for Cance
'"/>




Page: 1 2 3 4

Related medicine technology :

1. GenoMed Prevents Sickle Cell Pain for Over a Year
2. Progenics and Wyeth Announce Positive Results from Three-Month Clinical-Extension Study of Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness
3. Aeolus Pharmaceuticals AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation
4. Abraxis BioScience Presents Data from Pre-Clinical Study That Provide Evidence for Chemotherapy-Induced Angiogenesis and Rationale for Combining nab-Paclitaxel (Abraxane) with Anti-Angiogenic Agents to Increase Tumor Response
5. Cleveland BioLabs Protectan CBLB502 Demonstrates Strong Survival Benefits as Mitigator Against Radiation-Induced Damage in Study
6. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
7. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
8. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
9. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
Post Your Comments:
(Date:7/31/2014)... SAN DIEGO , July 31, 2014  Sorrento Therapeutics, ... death of Mr. Amar Singh , Chief Business Officer ... of apparent natural causes on July 30. "Sorrento ... dear friend and colleague. Our immediate thoughts go to Amar,s ... President and Chief Executive Officer. Mr. Singh ...
(Date:7/31/2014)... Tandem Diabetes Care®, Inc. (NASDAQ: TNDM ... Insulin Pump, today reported its financial results for the quarter ... second quarter of 2014 to the same period of 2013: ... $5.5 million , t:slim Pump shipments grew 64 percent ... six months ended June 30, 2014 to the same period ...
(Date:7/31/2014)... 31, 2014 Nektar Therapeutics (Nasdaq: NKTR ... ended June 30, 2014. Cash and investments ... as compared to $309.1 million at March 31, 2014."The second ... as we look forward to significant milestones for a number ... and Chief Executive Officer of Nektar. "The first of these ...
Breaking Medicine Technology:Sorrento Announces the Unexpected Death of its Chief Business Officer 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 5Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 7Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 8Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 9Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 10Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 11Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 12Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 13Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 14
... , THOUSAND OAKS, Calif., Dec. 3 Each year, hundreds ... Europe participate in the Amgen Scholars Program to gain hands-on ... universities. Now, the Amgen Scholars - past, present and ... Scholars Community at www.amgenscholars.com . , "The new ...
... MARQUETTE, Mich., Dec. 3 Pioneer Surgical Technology, Inc., ... awards in the Cervical Spine Care category at the ... Francisco, California in conjunction with the North American Spine ... receiving awards were the NuNec® Cervical Total Disc replacement ...
Cached Medicine Technology:New Amgen Scholars Web site Launches to Build a Global Network for Future Scientists 2New Amgen Scholars Web site Launches to Build a Global Network for Future Scientists 3Pioneer(R) Surgical Technology, Inc. Receives Prestigious Spine Technology Awards 2
(Date:8/1/2014)... OR (PRWEB) August 01, 2014 In ... called hydrotherapy – was fundamental to the practice of ... water researcher Sharon Kleyne, water therapy has been relegated ... time when climate change, water shortages, drought and pollution ... diseases, the Sharon Kleyne Hour Power of Water host ...
(Date:8/1/2014)... According to the Suspension Revolution 2.0 PDF review recently ... and women who want to get ripped abdominals within a ... 27 intense workouts that help blast fat and gain muscle ... Suspension Revolution 2.0 program provides users with easy tips and ... plans that help keep fit and stay healthy ...
(Date:8/1/2014)... August 01, 2014 Blindness is a ... that the scientists of today, despite well-meaning efforts, still have ... a definite treatment for reversing blindness that does not involve ... this is where alternative medicine takes the “slack” from the ... expensive treatments or harmful surgeries. , Alternative health specialist ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 Online retailer ... offering a low price guarantee on their inventory of ... adult diapers, wipes, and pads along with other personal ... can be to find a line of incontinence products ... you find one that works for you, you shouldn't ...
(Date:8/1/2014)... York, US (PRWEB) August 01, 2014 ... DataSite in partnership with PitchBook presents the 3Q 2014 ... all U.S private equity investment, exits and fundraising activity ... useful insight to help plan for private equity endeavors ... the registration form to download it now. , About ...
Breaking Medicine News(10 mins):Health News:Water Researcher Advocates Reevaluation of 18th and 19th Century Water Therapy Movement 2Health News:Water Researcher Advocates Reevaluation of 18th and 19th Century Water Therapy Movement 3Health News:Suspension Revolution 2.0 PDF Review Exposes Dan Long's Program For Building Muscle – Vkool.com 2Health News:Suspension Revolution 2.0 PDF Review Exposes Dan Long's Program For Building Muscle – Vkool.com 3Health News:The Miracle Cure Review | The Unbeatable Secret to Reversing Any Vision Problem – Vinamy.com 2Health News:Disposable Medical Express Offering Low Price Guarantee On Tranquility Products 2Health News:Register to Download Merrill DataSite's Report: PitchBook 3Q 2014 Private Equity Breakdown Report 2
... of a recent study researchers say weight gain after age ... for postmenopausal women who // are not taking hormone replacement ... ages 50 to 74, by asking them about their weight ... women have been periodically asked to provide updates on their ...
... in as little as two days of physical inactivity, the ... and other related diseases.// ,Researchers conducted a study in ... stayed inactive. When the rats stopped running for two days ... of sugar taken into the muscle in response to insulin ...
... New research suggests weight loss may be an early ... loss begins before the onset of // definite dementia ... ,Weight loss in the elderly is common and may ... been documented in people who already have dementia. For ...
... surgery may be at higher risk for bone fractures, say ... For the study, nearly 20 percent of men treated with ... diagnosis, compared to about 13 percent of men who did ... given to men with locally advanced cancers and the therapy ...
... estrogen may provide protection against colon cancer. For the ... and followed their progress for one year. The diets were ... one contained milk protein, and diet two had soy protein. ... diets contained soy protein with the addition of an estrogen ...
... genetic discovery could help give insight into a very deadly ... that codes for the progesterone receptor increase a woman’s risk ... to a higher ovarian cancer risk as well as a ... used biological samples from an ongoing study and examined the ...
Cached Medicine News:
The CGPL capsulotomy contact glass was designed by Riquin, Fankhauser et al. for the dissection of opacified posterior lens capsules and membranes in the pupillary and retropupillary space with the Y...
The CGAL gonioscopic contact glass was designed by Roussel and Fankhauser for,laser treatments of the chamber angle. It reduces the laser spot by a factor of 1.5 as compared to a Goldmann Glass....
The CGRL is a Wide Angle Contact Glass designed for laser photocoagulation and diagnosis of the retina....
The classic Goldmann Glass. Designed to work with argon/YAG Lasers....
Medicine Products: