Navigation Links
Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

BETHESDA, Md., April 1, 2007--Rapamycin, an FDA-approved drug normally used to help prevent the body from rejecting organ and bone marrow transplants and also used to coat cardiac stents, was highly effective in preventing the development of tobacco-related lung tumors in mice. In a study published in the April 1, 2007 issue of Clinical Cancer Research, researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, found that mice that were administered rapamycin one week after exposure to a very common tobacco-specific carcinogen showed a 90 percent decrease in the number of tumors, a 74 percent decrease in tumor size, and fewer abnormalities within their cancer cells. The scientists work also shows that mTOR, a protein targeted by rapamycin, plays a critical role in the early stages of development of certain lung tumors caused by tobacco exposure.

We estimate that there will be over 160,000 deaths from lung cancer this year, and 90 percent of those will be attributed to smoking. Quitting smoking reduces lung cancer risk by about 50 percent, said NCI Director John E. Niederhuber, M.D. By exploring methods of chemoprevention via agents such as rapamycin, we may be able to further reduce lung cancer risk.

Previous studies in mice have shown that nicotine and its metabolic byproduct, known as NNK, stimulate the activity of two proteins, Akt and mTOR, in normal cells that line the airways in the lungs. This activation makes the cells pre-cancerous. In addition, clinical studies have shown that Akt is activated in the majority of pre-cancerous lesions in smokers, and that Akt activation predicts shorter survival for non-small cell lung cancer patients, particularly for those in early stages or with small tumors. These studies suggested that Akt and mTOR are important elements in the formation and maintenance of tobacco-carcinogen induced lung tumors, and that targeting
'"/>




Page: 1 2 3 4

Related medicine technology :

1. GenoMed Prevents Sickle Cell Pain for Over a Year
2. Progenics and Wyeth Announce Positive Results from Three-Month Clinical-Extension Study of Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness
3. Aeolus Pharmaceuticals AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation
4. Abraxis BioScience Presents Data from Pre-Clinical Study That Provide Evidence for Chemotherapy-Induced Angiogenesis and Rationale for Combining nab-Paclitaxel (Abraxane) with Anti-Angiogenic Agents to Increase Tumor Response
5. Cleveland BioLabs Protectan CBLB502 Demonstrates Strong Survival Benefits as Mitigator Against Radiation-Induced Damage in Study
6. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
7. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
8. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
9. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
Post Your Comments:
(Date:8/27/2014)... and NINGBO, China , ... the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced ... development of generic pharmaceuticals, primarily targeting the ... the agreement, Amerigen and Menovo will jointly develop products ... States . Menovo will be responsible for manufacturing ...
(Date:8/27/2014)... Aug. 27, 2014 Ambit Biosciences (Nasdaq: AMBI ... drugs targeting unmet needs in oncology, autoimmune and inflammatory disease, ... Care Conference to be held at The New York Palace ... September 3-4, 2014. Alan Fuhrman , Ambit,s ... lead drug candidate, quizartinib, at 1:10 p.m. ET on Wednesday, ...
(Date:8/27/2014)... WARSAW, Ind. , Aug. 27, 2014  Zimmer ... in musculoskeletal care, announced that it will be participating ... the Grand Hyatt in New York, New ... David Dvorak , President and CEO of Zimmer, will ... Binder , President and CEO of Biomet, will join ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Ambit Announces Participation At Baird 2014 Health Care Conference 2
(Date:8/27/2014)... August 27, 2014 Shawna's new book, ... is about Seed Digging, which a brand-new technique she ... models, yet works to bring permanent healing quickly. , ... and mental health disorders cured on a daily basis. ... own minds and find incredible inner peace with only ...
(Date:8/27/2014)... Best SEO Hosting, a well-known SEO Hosts Review Site, has ... and GoDaddy are the most recommended suppliers for webmasters from ... hosting (including VPS and cloud hosting). , As one ... serving hosting small business websites since 1998. With more than ... the hosting industry for its affordable and easy to manage ...
(Date:8/27/2014)... The Latinos In Action Festival 2014 is being ... Florida State Fair Grounds from 9am - 9pm. Latinos ... from around the world. Latinos in Action Festival is ... and Univision Mobile, a service provided by T-Mobile company. ... 4,000 people from different backgrounds, cultures and nationalities. Come ...
(Date:8/27/2014)... HealthDay Reporter WEDNESDAY, Aug. ... in a dark alley will likely never want to return ... attacked. But neuroscientists working with mice say they,ve discovered ... positive and negative emotions. And in rodent tests, they,ve manipulated ... In essence, they made once-reluctant mice want to return ...
(Date:8/27/2014)... Dallas, Texas (PRWEB) August 28, 2014 ... Market Outlook to 2020?, provides key market data on ... millions of US dollars, volume (in units) and average ... (Rigid Tip Video Laparoscopes and Flexible Tip Video Laparoscopes), ... There are a number of advantages to the patient ...
Breaking Medicine News(10 mins):Health News:Shawna Burns, Counselor, Releases Debut Book, "Seed Digging," to Improve Lives of Children and Adults with Addictions and Mental Health Disorders 2Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 2Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 4
... Offered to Cancer Patients in HELIOS HospitalsBERLIN, March 10 ... Germany will gain access to the most modern radiotherapy ... that it is acquiring nine linear accelerators from Varian ... of them equipped with RapidArc(TM) technology for fast and ...
... are embracing technological advances, such as electronic medical records, ... their needs.Those are the results found in a recent ... The findings were published in the March/April issue of ... conducted the same survey back in 2004. Five years ...
... Inc. (TSX: DDS; NASDAQ: DDSS ) today announced ... will present at the Cowen and Company 29th Annual Health ... March 18, 2009 at 11:00 a.m. ET. , Interested parties ... the "Events" section of the homepage of the Company,s website ...
... Pressure Profile Systems, Inc. Combines Tactile and 3D ... Footbeds to ConsumersLOS ANGELES and SCOTTSDALE, Ariz., March ... (PPS) together with its partner eSoles, LLC, today ... (R) Kiosk Scanning System. The free-standing, ...
... KONG, March 10 /PRNewswire-Asia/ -- Obio Pharmaceutical Holdings Ltd,("Obio"/ ... of a drug,TG21, against main strains of influenza virus ... H5N1. The process leading to clinical,trials for TG21 has ... and will continue to engage prestigious institutions in USA ...
... Awareness of the KeepingYouWell.com Website for People Seeking Quality Care ... ... Blue Search Engine Marketing is pleased to announce Adventist Midwest Health ... on for a unique, highly targeted search engine optimization campaign, and ...
Cached Medicine News:Health News:Leading German Healthcare Group Selects Equipment and Software from Varian Medical Systems for Major Replacement Project 2Health News:Survey Results: Health Care Technology Advances as Physician Frustration Grows 2Health News:World's Most Advanced Foot Scanning Kiosk Made Available to Retailers by eSoles and Pressure Profile Systems, Inc. 2Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 2Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 3Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 2Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 3
... head design has been carefully considered with both ... head ensures the optimum viewing angle and the ... laser aligned for perfect focus where it is ... paper. This along with Keeler's wide angle ...
The Beta 200S combines Heine's patented aspherical optics (U.S. Pat. 4.963.014) and a single-step Rekoss disk with a range of 36 to +38 dpt. to provide perfectly-focused images even in cases of high ...
... 200S is the first hand-held ... of patented aspherical optics (U.S. ... of corrective lenses from 36 ... diopter steps. A perfectly-focused image ...
... The ophthalmoscope with superior aspherical optics. ... illumination and observation beam by means of ... iris reflex (Gullstrand-principle). The Beta 200 allows ... illuminated section of the retina even with ...
Medicine Products: