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Immunomedics Reports Initial Clinical Results With Hpam4 For,Pancreatic Cancer Therapy

- Results Presented at Society of Nuclear Medicine Annual Meeting -

WASHINGTON, June 05, 2007 /PRNewswire-FirstCall/ -- Immunomedics, Inc. , a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today announced that initial results from a Phase I study with the Company's humanized anti-MUC1 monoclonal antibody (hPAM4), labeled with the radioisotope, Yttrium-90 (Y-90), in patients with unresectable and metastatic pancreatic cancer reported at the 54th Annual Meeting of the Society of Nuclear Medicine in Washington, DC, by Seza Gulec, MD, Center for Cancer Care, Goshen, IN, were encouraging.

Stage III pancreatic cancer patients who have failed one line of chemotherapy and Stage IV patients with or without a history of systemic therapy were eligible for the open-label, multicenter dose-escalation study. Prior to therapy, all patients received a diagnostic dose of hPAM4 labeled with the radioisotope, Indium-111, to ensure an acceptable distribution within the body and radiation dose to the pancreas for intended therapy. Patients then received a single infusion of 90Y-hPAM4 with the Y-90 dose escalating in increments of 5mCi/m(2) in groups of 3-6 patients. CT based measurements were used to evaluate tumor response 4, 8, and 12-weeks after therapy.

Results from the Goshen study site were reported at the meeting. Eleven patients, of whom 9 had previously received systemic therapy predominantly with gemcitabine regimens, and 2 patients who were chemotherapy naïve were enrolled at this cancer center. In all patients, pre-therapy imaging with 111In-hPAM4 showed acceptable distribution within the body and radiation dosage to the pancreas. 90Y-hPAM4 was administrated at 15 mCi/m(2), 20 mCi/m(2) or 25 mCi/m(2). One patient, enrolled into the clinical trial at this site, showed shrinkage of a liver lesion.

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