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ImmuneRegen BioSciences Announces Promising Data on Homspera,Suggesting Potential as a Co-Therapeutic Agent

Compound Could Be Utilized as an Adjuvant and Play Key Role in the Treatment of Influenza and Cancer

SCOTTSDALE, Ariz., March 20, 2007 /PRNewswire-FirstCall/ -- ImmuneRegen BioSciences, a wholly owned subsidiary of IR BioSciences Holdings, Inc. , announced today that data obtained by the Company on its Substance P analog, Homspera, suggests that the compound has potential value as a co-therapeutic agent or vaccine adjuvant. Studies performed in animal models of influenza and acute radiation syndrome have revealed the potential capability of Homspera to enhance the action of approved antiviral medications as well as to provide adjunctive impact on antitumor radiation therapy.

Studies performed in the cotton rat model of influenza at Virion Systems, Inc. (VSI, a Maryland biotechnology corporation) have revealed the ability of Homspera to diminish the impact of influenza virus infection on animal weight loss and temperature. In addition, viral titers were found to be decreased up to 90% in lungs and nose of treated animals.

The Company believes that, in conjunction with a neuraminidase inhibitor such as oseltamivir (Tamiflu(R), Roche Pharmaceuticals), Homspera might be an effective adjuvant therapeutic by decreasing the number of viruses at which this enzyme would need to be inhibited.

Potential also exists for Homspera to be used as an adjuvant therapy for cancer patients, as treatment often includes radiation following chemotherapy, in an attempt to kill more of the cancer cells. Survival data from gamma- irradiated mice studies and mechanistic studies in cell culture have shown indications of hematopoietic stem cell replenishment of circulating leukocytes and platelets, which could be of value in radiation-treated cancer patients.

Studies in cell culture have revealed elevations in components of the innate immune system that are consistent with Toll-like Receptor activation, a postul
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